Abstract
Computational modeling can be defined as the use of computers for studying and simulating complex systems, such as the human brain, organisms, and Earth’s global climate, using mathematics, physics, and computer science. Cancer is a complicated and heterogeneous illness that involves a large number of cells, reactions, and events that take place throughout time. Computational modelling, in combination with experimental studies and clinical testing, can help researchers better understand cancer and develop better treatment techniques. Computational modeling supplies tools for tackling the complexity of cancer and providing a detailed mechanistic insight that tells us which treatment is appropriate for a patient, whether a cancer medicine will stop a tumour from growing and whether a cancer drug will have an effect on healthy tissues in the human body. Many previous studies of Computational modeling are used for cancer diagnosis that is comparatively efficient and less weak. Gene expression microarray technology, which is generally used for cancer diagnosis, prediction, or prognosis, suffers from the curse of a dimensional problem. This problem can be solved using gene selection, which is implemented to the microarray for choosing the most useful features from the original features. The selecting of the optimal number of informative genes is considered an NP-hard problem. The meta-heuristic algorithms (MAs) which are robust at choosing the best solutions for complicated optimization problems for solving NP-hard problems, are also beneficial for solving big problems in sensible computational time. Meta-heuristic algorithms have become popular and powerful in computational modeling and many applications. The core of meta-heuristics Algorithms (MAs) is convenient for choosing the most informative and relative features as preprocessing step to Machine Learning (ML) step for achieving the highest classification accuracy for cancer diagnosis. This chapter introduces a comparative study among the most common MAs algorithms combined with ML computational modeling techniques for cancer diagnosis.
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Houssein, E.H., Hassan, H.N., Al-Sayed, M.M., Nabil, E. (2022). Intelligent Computational Models for Cancer Diagnosis: A Comprehensive Review. In: Houssein, E.H., Abd Elaziz, M., Oliva, D., Abualigah, L. (eds) Integrating Meta-Heuristics and Machine Learning for Real-World Optimization Problems. Studies in Computational Intelligence, vol 1038. Springer, Cham. https://doi.org/10.1007/978-3-030-99079-4_2
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