Abstract
The identification of preventable and treatable causal factors, including hepatitis B (HBV), hepatitis C (HCV), alcoholism, and obesity (non-alcoholic steatotic hepatitis [NASH]). The characterization of molecular and proteomic profiles for HCC prognosis, disease subtyping, and rational drug selection.
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Keywords
- Hepatocellular Carcinoma
- Milan Criterion
- Advanced Hepatocellular Carcinoma
- Recurrent Hepatocellular Carcinoma
- Noncancerous Liver Tissue
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
Further reading
Carr BI. Some new approaches to the management of hepatocellular carcinoma. Semin Oncol. 2012;39:369-373.
Kim WR, Gores GJ Recurrent hepatocellular carcinoma: it’s the virus! J Clin Oncol. 2013;31:3621-3622.
Honda M, Yamashita T, Yamashita T, et al. Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. BMC Cancer. 2013;13:191.
Muto Y, Moriwaki H, Ninomiya M, et al. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med. 1996;13:1561-1567.
Minguez B, Hoshida Y, Villanueva A, et al. Gene-expression signature of vascular invasion in hepatocellular carcinoma. J Hepatol. 2011;55:1325-1331.
Zhu AX. Molecularly targeted therapy for advanced hepatocellular carcinoma in 2012: current status and future perspectives. Semin Oncol. 2012;39:493-502.
Kim SM, Leem SH, Chu IS, et al. Sixty-five gene-based risk score classifier predicts overall survival in hepatocellular carcinoma. Hepatology. 2012;55:1443-1452.
Nault JC, De Reynies A, Villanueva A, et al. A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection. Gastroenterology. 2013;145:176-187.
Hoshida Y, Villanueva A, Kobayashi M, et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008;359:1995-2004.
Utsunomiya T, Shimada M, Imura S, Morine Y, Ikemoto T, Mori M. Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma. J Gastroenterol. 2010;45:146-152.
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Carr, B.I. (2014). New Directions. In: Understanding Liver Cancer. Springer Healthcare, Tarporley. https://doi.org/10.1007/978-1-910315-02-6_5
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DOI: https://doi.org/10.1007/978-1-910315-02-6_5
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