Abstract
Several molecular factors contribute to the restricted neonatal repertoire. Among them, the most important are position-dependent usage of a few V gene families, shorter length of CDR3, lack of region diversity, and low frequency of somatic mutation. The ordered emergence of B-cell clones after birth is an additional, important factor. This may be because of the fact that some B-cell clones appear or mature at different rates rather than they do in concert. Studies using inbred animal strains demonstrated that the temporal pattern of B-cell clone emergence is similar in all individuals, indicating that a heritable genetic program determines the development of clones producing antibodies with various antigen specificities.
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© 2005 Humana Press Inc., Totowa, NJ
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(2005). Genetically Programmed Temporal Ordered Activation of Neonatal B-Cell Clones. In: Bona, C. (eds) Neonatal Immunity. Contemporary Immunology. Humana Press. https://doi.org/10.1007/978-1-59259-825-0_5
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DOI: https://doi.org/10.1007/978-1-59259-825-0_5
Publisher Name: Humana Press
Print ISBN: 978-1-58829-319-0
Online ISBN: 978-1-59259-825-0
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