Abstract
Cell-mediated immune (CMI) responses are mediated by T cells. T-cell subsets, such as Th1 and Th2, exhibit various functions. CD4 Th1 cells are the effectors of delayed-type hypersensitivity reactions, producing cytokines such as IFN-γ, which activates macrophage to kill obligatory intracellular pathogens, and interleukin (IL)-2, which promotes the growth of CD8 T cells. Th1 cells also promote class switching of IgM to IgG2. Th2 cells secrete cytokines to promote the B-cell activation and class switching of IgM to IgG1 and IgE. The CD8 cytotoxic T cells (CTLs) lyse cells infected with microbes (viruses, intracellular bacteria, and parasites) as well as cells expressing tumor-associated antigens. Therefore, CMI responses play an important role in immune defense reactions.
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Keywords
- Major Histocompatibility Complex Class
- Measle Virus
- Newborn Mouse
- Genetic Immunization
- Neonatal Immunity
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© 2005 Humana Press Inc., Totowa, NJ
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(2005). Cell-Mediated Immune Responses in Neonates. In: Bona, C. (eds) Neonatal Immunity. Contemporary Immunology. Humana Press. https://doi.org/10.1007/978-1-59259-825-0_12
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DOI: https://doi.org/10.1007/978-1-59259-825-0_12
Publisher Name: Humana Press
Print ISBN: 978-1-58829-319-0
Online ISBN: 978-1-59259-825-0
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