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Telomeres, DNA Repair Proteins, and Making Ends Meet

  • Chapter
DNA Damage and Repair

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

Telomeres are unique structures at the physical ends of linear eukaryotic chromosomes. They were first described over 60 years ago by Hermann Muller in his classic studies of the fruit fly Drosophilia melanogaster (78). He coined the name ‘telomere’ from the Greek—telos meaning end and meros meaning part—based on their chromosome end protection function. Shortly thereafter, Barbara McClintock’s cytogenetic observations in maize demonstrated that broken chromosomes could fuse with one another to form dicentric chromosomes (72,73). These early studies brought to light the fact that natural chromosome ends are distinguished from random breaks and protected from illegitimate end-joining reactions. How the cell accomplishes this critical discrimination is still under investigation.

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Authors
  1. Susan M. Bailey
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  2. Julianne Meyne
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  3. Edwin H. Goodwin
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Editor information

Editors and Affiliations

  1. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Jac A. Nickoloff

  2. Qbiogene, Carlsbad, CA, USA

    Merl F. Hoekstra

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© 2001 Humana Press Inc., Totowa, NJ

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Bailey, S.M., Meyne, J., Goodwin, E.H. (2001). Telomeres, DNA Repair Proteins, and Making Ends Meet. In: Nickoloff, J.A., Hoekstra, M.F. (eds) DNA Damage and Repair. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-095-7_14

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  • DOI: https://doi.org/10.1007/978-1-59259-095-7_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9635-2

  • Online ISBN: 978-1-59259-095-7

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