Abstract
The precise mechanism whereby methyldopa lowers blood pressure is not completely known, yet its antihypertensive effect is probably due to metabolism to alpha-methylnorepinephrine, which then lowers arterial pressure by stimulation of the central inhibitory alphaadrenergic receptors. False neurotransmission and/or reduction of plasma renin activity may also contribute to the action.
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Tallarida, R.J. (1982). Aldomet® (Merck Sharp & Dohme). In: TOP 200. Springer, New York, NY. https://doi.org/10.1007/978-1-4899-6746-6_6
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DOI: https://doi.org/10.1007/978-1-4899-6746-6_6
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