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Drug-Induced Psychosis

Neurobiological Mechanisms

  • Chapter
Substance Abuse and Psychopathology

Part of the book series: Applied Clinical Psychology ((ACPH))

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Abstract

Bonhoeffer (1910) initially made the distinction between endogenous and exogenous psychoses, suggesting that toxic-metabolic factors can produce symptoms similar to those of functional psychoses. Drug-induced psychoses have in the last 30 years been observed with a vast array of prescribed and illicit pharmacological agents. Accordingly, extensive work has been done in the past three decades, attempting to elucidate neurobiological mechanisms that underlie both natural and drug-induced psychotic states. Indeed, the current explosive growth in biological psychiatry was heralded by early hypotheses relating molecular structures of hallucinogens to those of endogenous biogenic amines (Osmond & Smythies, 1952). We (Ellinwood & Petrie, 1976, 1979) have previously described the complex interaction between clinical and pharmacological factors that affect behavioral-symptom outcomes of abused drugs in a clinical setting. In this chapter we address only the pharmacological aspect of illicit psychotomimetic drugs currently in popular usage, with specific focus on central neuronal mechanisms that are common to both the different drug categories and the natural psychoses.

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Authors and Affiliations

  1. Department of Psychiatry, School of Medicine, University of Kansas, Wichita, Kansas, 67214, USA

    Sam Castellani

  2. Department of Psychiatry, Vanderbilt University, Nashville, Tennessee, USA

    William M. Petrie

  3. Duke University Medical School, Durham, N.C., 27710, Box 3870, USA

    Everett Ellinwood Jr.

Authors
  1. Sam Castellani
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  2. William M. Petrie
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  3. Everett Ellinwood Jr.
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Editors and Affiliations

  1. Veterans Administration Medical Center, Philadelphia, Pennsylvania, USA

    Arthur I. Alterman

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Castellani, S., Petrie, W.M., Ellinwood, E. (1985). Drug-Induced Psychosis. In: Alterman, A.I. (eds) Substance Abuse and Psychopathology. Applied Clinical Psychology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-3641-7_8

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