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Pharmacokinetics and Metabolism of Therapeutic Cytokines

  • Chapter
Protein Pharmacokinetics and Metabolism

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 1))

Abstract

Tumor necrosis factor (TNF) was first described by Carswell and co-workers (1975) to cause necrosis in experimental tumors. Subsequent studies have shown that TNF is actually two factors, TNF-α and TNF-β; the latter is also known as lymphotoxin (Zahn and Greischel, 1989). Although both of these molecules have demonstrated a variety of biological effects, and both can bind to the same receptor, the majority of published work to date has described TNF-α or cachectin. Consequently, this section will focus exclusively on TNF-α.

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Authors and Affiliations

  1. Alkermes, Inc., Cambridge, Massachusetts, 02139, USA

    Carol A. Gloff

  2. R. W. Johnson Pharmaceutical Research Institute, Raritan, New Jersey, 08869, USA

    Robert J. Wills

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  1. Carol A. Gloff
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  1. R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA

    Bobbe L. Ferraiolo

  2. Genentech, Inc., South San Francisco, California, USA

    Marjorie A. Mohler

  3. Alkermes, Inc., Cambridge, Massachusetts, USA

    Carol A. Gloff

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© 1992 Springer Science+Business Media New York

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Gloff, C.A., Wills, R.J. (1992). Pharmacokinetics and Metabolism of Therapeutic Cytokines. In: Ferraiolo, B.L., Mohler, M.A., Gloff, C.A. (eds) Protein Pharmacokinetics and Metabolism. Pharmaceutical Biotechnology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2329-5_5

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  • DOI: https://doi.org/10.1007/978-1-4899-2329-5_5

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