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Binding Proteins of Protein Therapeutics

  • Chapter
Protein Pharmacokinetics and Metabolism

Part of the book series: Pharmaceutical Biotechnology ((PBIO,volume 1))

Abstract

Numerous examples of binding proteins for protein therapeutics have been reported. Binding proteins have been shown to exist for insulinlike growth factors I and II, tissue plasminogen activator, growth hormone, deoxyribonuclease I, tissue factor, nerve growth factor, transforming growth factor-β I and II, as well as others. Binding proteins may have either inhibitory or stimulatory effects, may modulate efficacy at the cellular level, and may also affect the pharmacokinetics and metabolism of protein therapeutics. Furthermore, the relative importance of binding proteins may be species or disease state specific. It is also important to realize that binding proteins may play a different role in the regulation of proteins when physiological concentrations of proteins are involved compared to pharmacological doses of protein therapeutics. The pharmacology, physiology, regulation, and interactions of binding proteins with their target proteins will be discussed. This review chapter will focus on insulinlike growth factor, tissue plasminogen activator, and growth hormone.

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Authors and Affiliations

  1. Department of Safety Evaluation, Genentech, Inc., South San Francisco, California, 94080, USA

    Marjorie A. Mohler & Jennifer E. Cook

  2. Center for Endocrinology, Metabolism, and Nutrition, Department of Medicine, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Gerhard Baumann

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  1. Marjorie A. Mohler
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  2. Jennifer E. Cook
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  3. Gerhard Baumann
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  1. R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania, USA

    Bobbe L. Ferraiolo

  2. Genentech, Inc., South San Francisco, California, USA

    Marjorie A. Mohler

  3. Alkermes, Inc., Cambridge, Massachusetts, USA

    Carol A. Gloff

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Mohler, M.A., Cook, J.E., Baumann, G. (1992). Binding Proteins of Protein Therapeutics. In: Ferraiolo, B.L., Mohler, M.A., Gloff, C.A. (eds) Protein Pharmacokinetics and Metabolism. Pharmaceutical Biotechnology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2329-5_2

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