Abstract
Oligo(glyme) plasma deposited films (PDFs) are of interest as biomaterials because of their ability to resist protein adsorption and cellular attachment.1 Oligo(glyme) plasma precursors (CH3−O−(CH2CH2O)n−CH3 (n=1−4)) contain the same repeat unit as poly(ethylene glycol) (PEG) and poly(ethylene oxide) (PEO) and are therefore expected to impart a PEG- or PEO-like character to a sample surface.* The minimally-adhesive properties of PEO-modified surfaces have been attributed to “passive” chemical properties such as the absence of sites for receptor binding2, hydrophobic attraction3,4 and ionic interaction. There is evidence that the surface structure is also involved in preventing adsorption—that more “active” steric, osmotic, and entropic repulsive forces arise between mobile, hydrated PEO chains and approaching biomolecules.4,5 But since fragmentation, rearrangement, crosslinking, polymerization, and etching reactions can all occur during plasma deposition6,7, the structure and chemistry of oligo(glyme) PDFs can be expected to differ considerably from that of PEO.
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Johnston, E.E., Ratner, B.D. (1996). XPS and SSIMS Characterization of Surfaces Modified by Plasma Deposited Oligo(Glyme) Films. In: Ratner, B.D., Castner, D.G. (eds) Surface Modification of Polymeric Biomaterials. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1953-3_5
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DOI: https://doi.org/10.1007/978-1-4899-1953-3_5
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