Abstract
Lipid peroxidation has been proposed to play an important role in the development of several diseases including atherosclerosis, chronic renal failure, diabetes, inflamation and neurodegnerative disorders. However, this issue has been difficult to address since specific and reproducible methods for the measurement of oxidative stress have been unavailable or unreliable1.
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References
Halliwell, B., Oxidative stress, nutrition and health: experimental strategies for optimization of nutritional antioxidant intake in humans, Free Radical Res. 25: 57 (1996).
Morrow, J.D., Hill, K.E., Burk, R.F., Mammour, T.M., Badr. K.F., and Roberts II, L.J., A series of prostaglandin F2-like compounds are produces in vivo in humans by a non-cyclooxgenase, free radical-catalyzed mechanism, Proc. Natl. Acad. Sci. USA 87: 9383 (1990).
Nourooz-Zadeh, J., Gopaul, N. K., Barrow, S., Mallet, A.I. and Änggård, E.E., Analysis of F2-isoprostanes as indicators of non-enzymatic lipid peroxidation in vivo by GC-MS: develoment of a solid phase extraction procedure, J. Chromatogr. Biomed. Appl. 667: 199 (1995).
Morrow, J.D., Harris, T.M., and Roberts H, L.J., Non-cyclooxgenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids, Anal Biochem. 184: 1 (1990).
Gopaul, N.K., Nourooz-Zadeh, J., Mallet, A.I., and Änggård, E.E., Formation of PGF2-isopratanes during the oxidative modication of LDL, Biochem. Biophysc. Res. Comm. 200: 338 (1994).
Gopaul, N.K., Nourooz-Zadeh, J., Mallet, A.I., and Änggård, E.E., Formation of F2-isoprostanes during aortic endothelial cell-mediated oxidation of LDL, FEBS Letters 348: 297 (1994).
Morrow, J.D, Frei, B., Longmire, A.W., Gaziano, J.M., Lynch, S.M., Shyr, Y., Strauss, W.E., Oates, J.A., and Roberts II, L.J., Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers, New Engl. J. Med. 332: 1198–1203 (1995).
Lynch, S.M., Morrow, J.D., Roberts II, L.J., and Frei, B, Formation of non-cyclooxgenase-derived prostanoid (F2-isoprostanes) in plasma and LDL exposed to oxidative stress in vitro, J. Clin. Invest. 93: 998 (1994).
Gopaul, N.K., Änggärd, E.E., Mallet, A.I., Bettridge, D.J, Wolff, S.P, and Nourooz-Zadeh, J., Plasma 8-epi PGF2α levels are elevated in individuals with NIDDM, FEBS Letters 368: 225 (1995).
Reilly, M., Delanty, N., Lawson, J. A., and Fitzgerald, G. A., Modulation of oxidant stress in vivo in chronic cigarette smokers, Circulation 94: 19 (1996).
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Nourooz-Zadeh, J., Änggård, E.E. (1997). Plasma 8-Epi PGF2α Levels in Health and Disease. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_39
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_39
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