Abstract
Cytochromes P450 (CYP) of liver microsomes can oxygenate polyunsaturated fatty acids1, 2. Hydroxylations of carbons at the ω end and epoxidations of the double bonds have attracted greatest attention. ω-Hydroxylation of polyunsaturated fatty acids is efficiently catalyzed by CYP4A, while other enzymes catalyze ω2 and ω3 hydroxylations of arachidonic acid (20: 4n-6). Enzymes of the CYP2B and CYP2C subfamily oxygenate 20: 4n-6 to epoxides1, 2, but all the constitutive epoxygenases may not have been identified.
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Hörnsten, L., Bylund, J., Oliw, E.H. (1997). Bisallylic Hydroxylation of Linoleic and Arachidonic Acids by Adult and Fetal Human Liver Microsomes and a Comparison with Human Recombinant Cytochromes P450. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_25
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_25
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