Abstract
The ability of cells to adapt by active processes to changes in external osmolarity has been known for a long time (3). Two new concepts have emerged in recent years: first, that the adaptive response is present in cells which grow and live in media of strictly controlled osmolarity, and secondly, that a number of organic molecules are importantly involved in volume regulation in vertebrates (5,8).
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Cserr, H.F., DePasquale, M., and Patlak, C.S. 1987, Regulation of brain water and electrolytes during acute hyperosmolality in rats, Am.J.Physiol., 253:F522–F529.
Gullans, S.R. and Verbalis, J.G. 1993, Control of brain volume during hyperosmolar and hypoosmolar conditions, Annu.Rev.Med., 44:289–301.
Hoffmann, E.K. and Simonsen, L.O. 1989, Membrane mechanisms in volume and pH regulation in vertebrate cells, Physiol.Rev., 69:315–382.
Kimelberg, H.K. and Ransom, B.R. 1986, Physiological and pathological aspects of astrocytic swelling, in: “Astrocytes, Vol. II”, Fedoroff, F. and Vernadakis, A., eds., Academic Press, New York, pp. 129–136.
Law, R.O. and Burg, M.B. 1991, The role of organic osmolytes in the regulation of mammalian cell volume, in: “Advances in Comparative and Environmental Physiology”, Gilles, R., ed., Springer-Verlag, Berlin, pp. 189–225.
Lehmann, A. 1989, Effects of microdialysis-perfusion with anisoomotic media on extracellular amino acids in the rat hippocampus and skeletal muscle, J.Neurochem., 53:525–535.
Oja, S.S. and Saransaari, P. 1992, Taurine release and swelling of cerebral cortex slices from adult and developing mice in media of different ionic compositions, J.Neurosci.Res., 32:551–561.
Pasantes-Morales, H. and Del Río, R.M. 1990, Taurine and mechanisms of cell volume regulation, in: “Taurine: Functional Neurochemistry, Physiology, and Cardiology”, Pasantes-Morales, H., Martin, D.L., Shain, W. and del Río, R.M., eds., Wiley-Liss, New York, pp. 317–328.
Pasantes-Morales, H., Maar, T.E., and Morán, J. 1993, Cell volume regulation in cultured cerebellar granule neurons, J.Neurosci.Res., 34:219–224.
Pasantes-Morales, H. and Schousboe, A. 1988, Volume regulation in astrocytes: A role for taurine as an osmoeffector, J.Neurosci.Res., 20:505–509.
Sánchez Olea, R. and Pasantes-Morales, H. 1990, Chloride dependence of the K+-stimulated release of taurine from synaptosomes, Neurochem.Res., 15:535–540.
Schousboe, A., Moran, J., and Pasantes-Morales, H. 1990, Potassium-stimulated release of taurine from cultured cerebellar granule neurons is associated with cell swelling, J.Neurosci.Res., 27:71–77.
Schousboe, A. and Pasantes-Morales, H. 1992, Role of taurine in neural cell volume regulation, Can.J.Physiol.Pharmacol., 70 Suppl.:S356–S361.
Schousboe, A., Sánchez Olea, R., Morán, J., and Pasantes-Morales, H. 1991, Hyposmolarity-induced taurine release in cerebellar granule cells is associated with diffusion and not with high-affinity transport, J.Neurosci.Res., 30:661–665.
Solís, J.M., Herranz, A.S., Herreras, O., Lerma, J., and Del Río, R.M. 1988, Does taurine act as an osmoregulatory substance in the rat brain, Neuroscience Letters, 91:53–58.
Sterns, R.S., Baer, J., Ebersol, S., Thomas, D., Lohr, J.W., and Kamm, D.E. 1993, Organic osmolytes in acute hypernatremia, Am.J.Physiol., 264:F833–F836.
Thurston, J.H., Hauhart, R.E., and Dirgo, J.A. 1980, Taurine: a role in osmotic regulation of mammalian brain and possible clinical significance, Life Sci., 26:1561–1568.
Wade, J.V., Olson, J.P., Samson, F.E., Nelson, S.R., and Pazdernik, T.L. 1988, A possible role for taurine in osmoregulation within the brain, J.Neurochem., 51:740–745.
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Pasantes-Morales, H., Chacón, E., Sánchez-Olea, R., Morán, J. (1994). Volume Regulation in Cultured Neurons: Pivotal Role of Taurine. In: Huxtable, R.J., Michalk, D. (eds) Taurine in Health and Disease. Advances in Experimental Medicine and Biology, vol 359. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1471-2_32
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DOI: https://doi.org/10.1007/978-1-4899-1471-2_32
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