Skip to main content

Abstract

Schizophrenia is a severe mental disorder characterized by disturbances of thought, perception, emotion, and behavior leading to considerable suffering and social deterioration. Widely believed to have multiple etiologies, schizophrenia is a syndrome with much variability in age at onset, symptomatology, course of illness, and response to treatment. Symptom development may be insidious or abrupt, with peak age at onset for males occurring in late adolescence or early adulthood. Females show a broader and later peak age at onset, with a second, smaller rise in new cases in the fourth decade.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Adler, L., Angrist, B., Peselow, E., Corwin, J., Maslansky, R., & Rotrosen, J. (1986). A controlled assessment of propranolol in the treatment of neuroleptic-induced akathisia. British Journal of Psychiatry, 149, 42–45.

    Article  PubMed  Google Scholar 

  • Alford, G. (1986). Behavioral treatment of schizophrenic delusions: A single-case experimental analysis. Behavior Therapy, 17(5), 656–644.

    Article  Google Scholar 

  • Allen, H., & Bass, C. (1992). Coping tactics and the management of acutely distressed schizophrenic patients. Behavioral Psychotherapy, 20(1), 61–72.

    Article  Google Scholar 

  • American Psychiatric Association (1987). Diagnostic and statistical manual of mental disorders (3rd ed., rev.). Washington, DC: Author.

    Google Scholar 

  • Anderson, C. M., Reiss, D. J., & Hogarty, G. E. (1986). Schizophrenia in the family. New York: Guilford.

    Google Scholar 

  • Baldessarini, R. (1990). Drugs and the treatment of psychiatric disorders. In G. A. Gilman, T. W. Roll, A. S. Nies, & T. Palmer (Eds.), The pharmacological basis of therapeutics (pp. 383–435). New York: Pergamon.

    Google Scholar 

  • Baldessarini, R. J., Cohen, B. M., & Teicher, M. H. (1988). Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychosis. Archives of General Psychiatry, 45, 79–91.

    Article  PubMed  Google Scholar 

  • Becker, R. B. (1988). Depression in schizophrenia. Hospital and Community Psychiatry, 39, 1269–1275.

    PubMed  Google Scholar 

  • Beitchman, J. H. (1985). Childhood schizophrenia: A review and comparison with adult-onset schizophrenia. Psychiatric Clinics of North America, 8, 793–814.

    PubMed  Google Scholar 

  • Campbell, M., Green, W. H., & Deutch, S. I. (1985). Child and adolescent psychopharmacology. Beverly Hills, California: Sage.

    Google Scholar 

  • Carpenter, W. T., Jr., Strauss, J. S., & Bartko, J. J. (1974). Use of signs and symptoms for the identification of schizophrenic patients. Schizophrenia Bulletin, 11, 37–49.

    Article  PubMed  Google Scholar 

  • Carpenter, W. T., Hanlon, T. E., Heinrichs, D. W., Summerfelt, A. T., Kirkpatrick, B., Levine, J., & Buchanan, R. W. (1990). Continuous vs. targeted medication in schizophrenic outpatients: Outcome results. American Journal of Psychiatry, 147, 1138–1148.

    PubMed  Google Scholar 

  • Christison, G. W., Kirch, D. G., & Wyatt, R. J. (1991). When symptoms persist: Choosing among alternative treatments for schizophrenia. Schizophrenia Bulletin, 17, 217–245.

    Article  PubMed  Google Scholar 

  • Cole, J. O. (1964). NIMH-Psychopharmacology Service Center Collaborative Study Group. Phenothiazine treatment in acute schizophrenia: Effectiveness. Archives of General Psychiatry, 10, 246–261.

    Article  Google Scholar 

  • Creese, I., Burt, D. R., & Snyder, S. H. (1975). Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science, 192, 481–483.

    Article  Google Scholar 

  • Crow, T. J., MacMillan, J. F., Johnson, A. L., & Johnstone, E. C. (1986). The Northwick Park study of first episodes of schizophrenia. II. A randomized controlled study of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148, 115–120.

    Article  PubMed  Google Scholar 

  • Davis, J. M. (1975). Overview: Maintenance therapy in psychiatry. I. Schizophrenia. American Journal of Psychiatry, 132, 1237–1245.

    PubMed  Google Scholar 

  • Deberdt, R., Elens, P., Berghmans, J., Heykants, R., Woestenborghs, F., Reyntjiens, A., & Van Wungaarden, I. (1980). Intramuscular haloperidol decanoate for neuroleptic maintenance therapy. Acta Psychiatrica Scandinavica, 62, 356–565.

    Article  PubMed  Google Scholar 

  • Dunham, H. W. (1965). Community and schizophrenia: An epidemiological analysis. Detroit: Wayne State University Press.

    Google Scholar 

  • Ganguli, R., Rabin, B. S., & Kelly, R. H. (1989). Multiple autoantibodies and autoimmune process in schizophrenic patients: Evidence for an autoimmune pathogenesis. In Hadden, J. W., Masek, K, & Nistico, G. (Eds.), Interaction among CNS, neuroendocrine and immune systems (pp. 365–383). Rome-Milan: Pythagora.

    Google Scholar 

  • Goff, C. G., & Baldessarini, R. J. (1993). Drug interactions with antipsychotic agents. Journal of Clinical Psychopharmacology, 13(1), 57–67.

    Article  PubMed  Google Scholar 

  • Goldstein, M. J., Rodrick, E. H., Evans, J. R., May, P. R. A., & Steinberg, M. R. (1978). Drug and family therapy in the aftercare of acute schizophrenics. Archives of General Psychiatry, 35, 1169–1177.

    Article  PubMed  Google Scholar 

  • Herz, M. I., & Melville, C. (1980). Relapse in schizophrenia. American Journal of Psychiatry, 137, 801–805.

    PubMed  Google Scholar 

  • Hogarty, G. E., Anderson, C. M., Reiss, D. T., Kornblith, S. T., & Greenwald, D. P. (1986). Family psychoeducation, social skills training, and maintenance chemotherapy in the aftercare of schizophrenia. Archives of General Psychiatry, 43, 633–642.

    Article  PubMed  Google Scholar 

  • Hogarty, G. E., McEvoy, J. P., Munetz, M., Dibarry, A. L., Bartone, P., & Cather, R. (1988). Environmental/personal indicators in the course of schizophrenia research group: Dose of fluphenazine, familial expressed emotion, and outcome in schizophrenia. Archives of General Psychiatry, 45, 797–805.

    Article  PubMed  Google Scholar 

  • Jann, M. W., Ereshefsky, L, & Saklad, S. R. (1985). Clinical pharmacokinetics of the depot antipsychotics. Clinical Pharmacokinetics, 10, 315–333.

    Article  PubMed  Google Scholar 

  • Javitt, D. C., & Zukin, S. R. (1991). Recent advances in the phencyclidine model of schizophrenia. American Journal of Psychiatry, 148, 1301–1308.

    PubMed  Google Scholar 

  • Kane, J. M. (1989). The current status of neuroleptic therapy. Journal of Clinical Psychiatry, 50, 322–328.

    PubMed  Google Scholar 

  • Kane, J. M., & Lieberman, J. A. (1987). Maintenance pharmacotherapy in schizophrenia. In H. Y. Meltzer (ED), Psychopharmacology: The third generation of progress. New York: Raven.

    Google Scholar 

  • Kane, J. M., & Selzer, J. (1991). Consideration of “organic” exclusion criteria for schizophrenia. Schizophrenia Bulletin, 17, 69–73.

    Article  PubMed  Google Scholar 

  • Kane, J. M., Woerner, M., Weinhold, P., Wegner, J., Kinon, B., & Borenstein, M. (1984). Incidence of tardive dyskinesia: Five-year data from a prospective study. Psychopharmacology Bulletin, 20, 387–389.

    PubMed  Google Scholar 

  • Keshavan, M. S., & Keshavan, A. (1992). Drug induced psychotic disorders. In Keshavan, M. S., & Kennedy, J. S. (Eds.), Drug-induced dysfunction in psychiatry (pp. 202–207). New York: Hemisphere.

    Google Scholar 

  • Kingdon, D. G., & Turkington, D. (1992). The use of cognitive behavioral therapy with a normalizing rationale in schizophrenia: Preliminary report. Journal of Nervous and Mental Disease, 179(4), 207–211.

    Article  Google Scholar 

  • Leff, J., Kuipers, L., Berkowitz, R., & Sturgeon, D. (1985). A controlled trial of social intervention in the families of schizophrenic patients: Two year follow up. British Journal of Psychiatry, 146, 594–600.

    Article  PubMed  Google Scholar 

  • Lieberman, J. A., Kane, J. M., & Johns, C. A. (1989). Clozapine: Guidelines for clinical management. Journal of Clinical Psychiatry, 50, 329–338.

    PubMed  Google Scholar 

  • Malm, U. (1982). The influence of group therapy on schizophrenia. Acta Psychiatrica Scandinavica, 297(Suppl.), 1–65.

    Article  PubMed  Google Scholar 

  • May, P. R., Tuma, A. H., Yale, C., Potepan, P., & Dixon, W. J. (1976). Schizophrenia—A follow-up study of results of treatment. II: Hospital stay over two to five years. Archives of General Psychiatry, 33, 481–506.

    Article  PubMed  Google Scholar 

  • McCracken, J. T. (1987). Lead intoxication psychosis in an adolescent. Journal of the American Academy of Child and Adolescent Psychiatry, 26, 274–276.

    Article  PubMed  Google Scholar 

  • McEvoy, J. P., Hogarty, G. E., & Steingard, S. (1991). Optimal dose of neuroleptic in acute schizophrenia. Archives of General Psychiatry, 48, 739–745.

    Article  PubMed  Google Scholar 

  • Murray, R. M., O’Callaghan, E., Castle, D. J., & Lewis, S. (1992). A neurodevelopmental approach to the classification of schizophrenia. Schizophrenia Bulletin, 18(2), 319–332.

    Article  PubMed  Google Scholar 

  • Nasrallah, H. A. (1986). The differential diagnosis of schizophrenia: Genetic, perinatal, neurological, pharmacological and psychiatric factors. In H. A. Nasrallah & D. R. Weinberger (Eds.), Handbook of schizophrenia (pp. 49–64). New York: Elsevier.

    Google Scholar 

  • Nayak, R. K., Doose, D. R., & Nair, N. P. V. (1987). The bioavailability and pharmacokinetics of oral and intramuscular haloperidol in schizophrenic patients. Journal of Clinical Psychopharmacology, 27, 144–150.

    Google Scholar 

  • Profita, J., Carrey, N., & Klein, F. (1989). Sustained, multimodal outpatient group therapy for chronic psychotic patients. Hospital and Community Psychiatry, 40(9), 943–946.

    PubMed  Google Scholar 

  • Realmuto, G. M., Erickson, W. D., Yellin, A. M., Hopwood, J. H., & Greenberg, L. M. (1984). Clinical comparison of thiothixene and thioridazine in schizophrenic adolescents. American Journal of Psychiatry, 141, 440–442.

    PubMed  Google Scholar 

  • Rifkin, A., Seshagiri, D., Basawaraj, K., Borenstein, M., & Wachpress, W. (1991). Dosage of haloperidol for schizophrenia. Archives of General Psychiatry, 48, 166–170.

    Article  PubMed  Google Scholar 

  • Rifkin, A., & Siris, S. (1987). Drug treatment of acute schizophrenia. In H. Y. Meltzer (Ed.), Psychopharmacology: The third generation of progress (pp. 1095–1102). New York: Raven.

    Google Scholar 

  • Roy, A. (1986). Suicide in schizophrenia. In A. Roy (Ed.), Suicide (pp. 95–112). Baltimore: Williams & Wilkins.

    Google Scholar 

  • Salzman, C. (1989). Use of benzodiazepines to control disruptive behavior in inpatients. Journal of Clinical Psychiatry, 49(Suppl). 13–15.

    Google Scholar 

  • Schneider, K. (1959). Clinical psychopathology. New York: Grune & Stratton.

    Google Scholar 

  • Schooler, N. (1991). Maintenance medication for schizophrenia: Strategies for dose reduction. Schizophrenia Bulletin, 17, 311–324.

    Article  PubMed  Google Scholar 

  • Schooler, N., & Hogarty, G. (1987). Medication and psychosocial strategies in the treatment of schizophrenia. In H. Y. Meltzer (Ed.), Psychopharmacology: The third generation of progress (pp. 1111–1120). New York: Raven.

    Google Scholar 

  • Simpson, G. E., Yadalam, K. G., Levinson, D. F., Stephanos, M. J., Lo, E. S., & Cooper, T. B. (1990). Single-dose pharmacokinetics of fluphenazine after fluphenazine decanoate administration. Journal of Clinical Psychopharmacology, 10(6), 417–421.

    Article  PubMed  Google Scholar 

  • Stanton, A. H., Gunderson, J. G., Knapp, P. H., Frank, A. F., Vanicelli, M. L., Schnitzer, R., & Rosenthal, R. (1984). Effects of psychotherapy in schizophrenia. Schizophrenia Bulletin, 10, 520–563.

    Article  PubMed  Google Scholar 

  • VanPutten, T. (1974). Why do schizophrenic patients refuse to take their drugs? Archives of General Psychiatry, 31, 67–72.

    Article  Google Scholar 

  • VanPutten, T., Marder, S., & Mintz, J. (1990). A controlled dose comparison of haloperidol in newly admitted schizophrenic patients. Archives of General Psychiatry, 47, 754–758.

    Article  Google Scholar 

  • Vaughn, C. E., & Leff, J. P. (1976). The influence of family and social factors on the course of psychiatric illness. British Journal of Psychiatry, 129, 125–137.

    Article  PubMed  Google Scholar 

  • Wallace, C. J., & Iiberman, R. P. (1985). Social skills training for patients with schizophrenia: A controlled clinical trial. Psychiatry Research, 15, 239–247.

    Article  PubMed  Google Scholar 

  • Werry, J., McClellan, J., & Chard, L. (1991). Childhood and adolescent schizophrenia, bipolar, and schizo-affective disorders: A clinical and outcome study. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 457–465.

    Article  PubMed  Google Scholar 

  • Wyatt, R. J. (1991). Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17, 325–351.

    Article  PubMed  Google Scholar 

  • Yadalam, K. G., & Simpson, G. M. (1988). Changing from oral to depot fluphenazine. Journal of Clinical Psychiatry, 49(9), 346–348.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer Science+Business Media New York

About this chapter

Cite this chapter

Anderson, S.A., Vaulx-Smith, P., Keshavan, M.S. (1994). Schizophrenia. In: Hersen, M., Ammerman, R.T. (eds) Handbook of Prescriptive Treatments for Adults. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1456-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1456-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1458-3

  • Online ISBN: 978-1-4899-1456-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics