Summary
This study investigated the increase in gastric acid secretion induced by intravenous administration of 2-deoxy-D-glucose (2-DG; 60 mg kg’1), insulin (5 U kg-1) or by electrical stimulation of the vagus nerve (1 mA, 1 ms, 3 Hz) in urethane-anesthe-tized rats pretreated when newborn with either capsaicin or the vehicle.
The secretory response to 2-DG was substantially reduced in the capsaicin pretreated rats, while those induced by electrical vagal stimulation or insulin were unaffected.
These findings suggest that capsaicin-sensitive fibers are involved in the afferent branch of the reflex response activated by 2-DG to stimulate gastric acid secretion.
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Evangelista, S., Santicioli, P., Maggi, C.A. (1991). 2-Deoxy-D-Glucose (2-DG)-Induced Increase in Gastric Acid Secretion is Impaired in Capsaicin-Pretreated Rats. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_27
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DOI: https://doi.org/10.1007/978-1-4899-0744-8_27
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