Abstract
There is growing evidence that capsaicin-sensitive afferent neurones participate in the protective mechanisms of the gastric mucosa against damage. Animals pretreated systemically with capsaicin, at doses that lead to the ablation of capsaicin-sensitive afferent neurons, show an increase in the level of macro-scopically apparent mucosal damage in different experimental models of ulceration (Szolcsányi and Barthó, 1981; Holzer and Sametz, 1986). Furthermore, acute stimulation with capsaicin of afferent nerve endings located in the gastric mucosa protects against different ulcerogenic mechanisms (Szolcsányi and Barthó, 1981; Holzer and Lippe, 1988; Holzer et al., 1989).
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References
Barthó, L., and Szolcsányi, J., 1981, Opiate agonists inhibit neurogenic plasma extravasation in the rat, Eur. J. Pharmacol., 73:101.
Bentley, G.A., Newton, S.H., and Starr, J., 1981, Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum, Br. J. Pharmacol., 73:325.
Brodin, E., Gazelius, B., Panopoulos, P., and Olgart, L., 1983, Morphine inhibits substance P release from peripheral sensory nerve endings, Acta Physiol. Scand., 117:567.
Esplugues, J.V., and Whittle, B.J.R., 1988, Gastric mucosal damage by local intra-arterial administration of Paf in the rat, Br. J. Pharmacol., 93:222.
Esplugues, J.V., and Whittle, B.J.R., 1989a, Gastric effects of Paf, Meth. Find. Exp. Clin. Pharmacol., 11(Suppl.1): 61.
Esplugues, J.V., and Whittle, B.J.R., 1989b, Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats, Am. J. Physiol., 256:G275.
Esplugues, J.V., Whittle, B.J.R., and Moncada, S., 1989, Local opioid-sensitive afferent sensory neurones in the modulation of gastric damage induced by Paf, Br. J. Pharmacol., 97:579.
Esplugues, J.V., and Whittle, B.J.R., 1990, Morphine potentiation of ethanol-induced gastric mucosal damage in the rat: Role of local sensory afferent neurons, Gastroenterology, 98:82.
Ferreira, S.H., and Nakamura, M., 1979, II-Prostaglandin hyperalgesia. The peripheral analgesic activity of morphine, enkephalins and opioid antagonists, Prostaglandins, 18:191.
Gamse, R., and Saria, A., 1987, Antidromic vasodilatation in the rat hindpaw measured by laser Doppler flowmetry: pharmacological modulation, J. Auton. Nerv. Syst., 19:105.
Gyires, K., Fürst, S., Farczadi, E., and Marton, A., 1985, Morphine potentiates the gastroulcerogenic effect of indomethacin, Pharmacology, 30:25.
Holzer, P., and Sametz, W., 1986, Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neurons, Gastroenterology, 91:97.
Holzer, P., and Lippe, I. Th., 1988, Stimulation of afferent nerve endings by intragastric capsaicin protects against ethanol-induced damage of the gastric mucosa, Neuroscience, 27:981.
Holzer, P., Pabst, M.A., and Lippe, I. Th., 1989, Intragastric capsaicin protects against aspirin-induced lesion formation and bleeding in the rat gastric mucosa, Gastroenterology, 96:1425.
Kao, C.Y., 1966, Tetrodotoxin, saxitonin and their significance in the study of excitation phenomena, Pharmacol. Rev., 18:997.
Konishi, S., Tsunoo, A., Yanaihara, N., and Otsuka, M., 1980, Peptidergic excitatory and inhibitory synapses in mammalian sympathetic ganglia: roles of substance P and enkephalin, Biomed. Res., 1:528.
Lembeck, F., and Donnerer, J., 1985, Opioid control of the function of primary afferent substance P fibres, Eur. J. Pharmacol., 114:241.
Pique, J.M., Esplugues, J.V., and Whittle, B.J.R., 1990, Influence of morphine or capsaicin pretreatment on rat gastric microcirculatory response to PAF, Am. J. Physiol., in press.
Rosam, A.C., Wallace, J.L., and Whittle, B.J.R., 1986, Potent ulcerogenic actions of platelet-activating factor on the stomach, Nature, 319:54.
Russell, N.J.W., Schaible, H.-G., and Schmidt, R.F., 1987, Opiates inhibit the discharges of fine afferent units from inflamed knee joint of the cat, Neurosci. Lett., 76:107.
Selye, M., 1935, A syndrome produced by diverse nocuous agents, Nature, 138:32.
Smith, T.W., Buchan, P., Parsons, D.N., and Wilkinson, S., 1982, Peripheral antinoceptive effects of N-methylmorphine, Life Sci., 31:1205.
Szolcsányi, J., and Barthó, L., 1981, Impaired defense mechanisms to peptic ulcer in the capsaicin-desensitized rat, in: “Gastrointestinal Defense Mechanisms”, Gy. Mozsik, O. Hanninen, and T. Javor, eds., Pergamon Press and Akademiai Kiado, Oxford and Budapest.
Till, M., Gati, T., Rabai, K., Szombath, D., and Szekeley, J.I., 1988, Effect of [D-Met2-Pro5] enkephalinamide on gastric ulceration and transmucosal potential difference, Eur. J. Pharmacol., 150:3 25.
Whittle, B.J.R., Morishita, T., Ohya, Y., Leung, F.W., and Guth, P.H., 1986, Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa, Am. J. Physiol., 251:G77.
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Esplugues, J.V., Whittle, B.J.R. (1991). Opioid-Sensitive Peripheral Neuronal Activity in the Modulation of Gastric Mucosal Injury. In: Costa, M., Surrenti, C., Gorini, S., Maggi, C.A., Meli, A. (eds) Sensory Nerves and Neuropeptides in Gastroenterology. Advances in Experimental Medicine and Biology, vol 298. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0744-8_12
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DOI: https://doi.org/10.1007/978-1-4899-0744-8_12
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