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Epidermal Growth Factor and Transforming Growth Factor-α

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Since its discovery in 1963 as a polypeptide that accelerated the in vivo maturation of epithelial tissues (Cohen and Elliott, 1963), epidermal growth factor (EGF) has been assumed to be important in regulating epidermal growth, differentiation, and repair. Over the last 30 years, the concepts inherent to EGF and its related growth factors have merged with that of lymphokines, interferons, and cytokines to become synonymous with small peptide factors that regulate multiple functions of cells and tissues. The regulatory signals induced by binding of soluble and matrix protein-bound growth factors/cytokines to specific receptors is termed signal transduction. Although in vitro and in vivo biochemical and genetic studies of signal transduction are unfolding at a rapid pace, these complex signaling mechanisms have not yet been evaluated in the more complicated milieu within cutaneous wounds. To provide an appropriate background for this chapter on EGF and its common factors involved in wound healing, a brief description of this expanding family of EGF-like molecules, their cellular interactions, and emerging signal transduction mechanisms is described below.

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Authors and Affiliations

  1. Departments of Plastic Surgery, Cell Biology, and Dermatology, Department of Veteran’s Affairs, Vanderbilt University Medical Center, Nashville, Tennessee, 37232-2631, USA

    Lillian B. Nanney & Lloyd E. King Jr.

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  1. Lillian B. Nanney
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  2. Lloyd E. King Jr.
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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Nanney, L.B., King, L.E. (1988). Epidermal Growth Factor and Transforming Growth Factor-α. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_5

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  • DOI: https://doi.org/10.1007/978-1-4899-0185-9_5

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