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Mechanisms of Parenchymal Cell Migration into Wounds

  • Chapter
The Molecular and Cellular Biology of Wound Repair

Abstract

Cellular motility is a fundamental consideration in the successful healing of wounds. While much effort has appropriately been recently placed on understanding the molecular basis of adhesion and signaling mechanisms involved in cell motility, it is important to keep in mind that these processes occur in the context of a complex and changing wound environment, which includes soluble and insoluble (i.e., density) gradients of cell motility-promoting components. A number of cell types must enter the wound in a relatively coordinated fashion, and this is controlled, in part, by modulating both the increased random and directed migration of cells.

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References

  • Akiyama, S. K., Nagata, K., and Yamada, K., 1990, Cell surface receptors for extracellular matrix components, Biochim Biophys Acta 1031:91–110.

    Article  PubMed  CAS  Google Scholar 

  • Akiyama, S. K., Yamada, S. S., Yamada, K. M., and LaFlamme, S. E., 1994, Transmembrane signal transduction by integrin cytoplasmic domains expressed in single-subunit chimeras, J. Biol. Chem. 269:15961–15964.

    PubMed  CAS  Google Scholar 

  • Barondes, S. H., 1988, Bifunctional properties of lectins: lectins redefined. Trends in Biochem. Sci. 13:480–482.

    Article  CAS  Google Scholar 

  • Bennett, K. L., Jackson, D. G., Simon, J. C., Tanczos, E., Peach, R., Modrell, B., Stamenkovic, I., Plowman, G., and Aruffo, A., 1995, CD44 isoforms contain exon V3 are responsible for presentation of heparin-binding growth factor, J. Cell Biol. 128:687–698.

    Article  PubMed  CAS  Google Scholar 

  • Bergmann, J. E., Kupfer, A., and Singer, S. J., 1983, Membrane insertion at the leading edge of motile fibroblasts, Proc. Natl. Acad. Sci. USA 80:1367–1371.

    Article  PubMed  CAS  Google Scholar 

  • Brown, T. A., Bouchard, T., St. John, T., Wayner, E., and Carter, W. G., 1991, Human keratinocytes express a new CD44 core protein (CD44E) as a heparan-sulfate intrinsic membrane proteoglycan with additional exons, J. Cell Biol. 113:207–221.

    Article  PubMed  CAS  Google Scholar 

  • Carter, S. B., 1967, Haptotactic Islands. A method of confining single cells to study individual cell reactions and clone fermentation, Exp. Cell Res. 48:188–193.

    Article  Google Scholar 

  • Carter, S. B., 1967, Haptotaxis and the mechanism of cell motility, Nature 213:256–260.

    Article  PubMed  CAS  Google Scholar 

  • Caterina, M. J., and Devreotes, P. N., 1991, Molecular insights into eukaryotic chemotaxis, FASEB J. 5:3078–3085.

    PubMed  CAS  Google Scholar 

  • Chan, B. M., Kassner, P. D., Schiro, J. A., Byers, H. R., Kuppe, T. S., and Hemler, M. E., 1992, Distinct cellular functions mediated by different VLA integrin a subunit cytoplasmic domains, Cell 68:1051–1060.

    Article  PubMed  CAS  Google Scholar 

  • Chen, W.-T., 1981, Mechanism of retraction of the trailing edge during fibroblast movement, J. Cell Biol. 90:187–200.

    Article  PubMed  CAS  Google Scholar 

  • Clark, R. A. F., Winn, H. J., Dvorak, H. F., and Colvin, R. B., 1983, FIbronectin beneath reepithelializing epidermis in vivo: Sources and significance, J. Invest. Dermatol. 80(Suppl):26s–30s.

    Article  CAS  Google Scholar 

  • Clark, R. A. F., Nielsen, L. D., Howell, S. E., and Folkvord, J. M., 1985, Human keratinocytes that have not terminally differentiated synthesize laminin and fibronectin by deposit on fibronectin in the pericellular matrix, J. Cell Biochem. 28:127–141.

    Article  PubMed  CAS  Google Scholar 

  • Condeelis, J., Jones, J., and Segall, J. E., 1992, Chemotaxis of metastatic tumor cells: clues to mechanisms from dictyostelium paradigm, Cancer Metastasis Rev. 11:55–68.

    Article  PubMed  CAS  Google Scholar 

  • Cooper, J. A., 1991, The role of actin polymerization in cell motility, Annual Review of Physiology 53:585–605.

    Article  PubMed  CAS  Google Scholar 

  • Cunningham, C. C., Stossel, T. P., and Kwiatkowski, D. J., 1991, Enhanced motility of NIH 3T3 fibroblasts that overexpress gelsolin, Science 251:1233–1236.

    Article  PubMed  CAS  Google Scholar 

  • Damsky, C. H., and Werb, Z., 1992, Signal transduction by integrin receptors for extracellular matrix: coooperative processing of extracellular information, Cur. Opin. Cell Biol. 4:772–781.

    Article  CAS  Google Scholar 

  • Davis, B. H., Walter, R. J., Pearson, C. B., Becker, E. L., and Oliver, J. M., 1982, Membrane activity and topography of f-MET-Leu-Phe-treated polymorphonuclear leukocytes, Am. J. Pathol. 108:206–213.

    PubMed  CAS  Google Scholar 

  • Dedhar, S., Rennie, P. S., Shago, M., Hagesteijn, C. Y., Yang, H., Filmus, J., Hawley, R. G., Bruchovsky, N., Cheng, H., and Matusik, R. J., 1994, Inhibition of nuclear hormone receptor activity by calreticulin, Nature 367:480–483.

    Article  PubMed  CAS  Google Scholar 

  • Devrotes, P., and Zigmond, S., 1988, Chemotaxis in eukaryotic cells, Annu. Rev. Cell Biol. 4:649–686.

    Article  Google Scholar 

  • Divecha, N., and Irvine, R. F., 1995, Phospholipid signaling, Cell 80:269–278.

    Article  PubMed  CAS  Google Scholar 

  • Erickson, C.A., 1990, Cell migration in the embryo and adult organism, Curr. Opin. Cell Biol. 2:61–74.

    Article  Google Scholar 

  • Erickson, H. P., and Bourdon, M. A., 1989, Tenascin: An extracellular matrix protein prominent on specialized embryonic tissues and tumors, Annu. Rev. Cell Biol. 5:71–92.

    Article  PubMed  CAS  Google Scholar 

  • Faassen, A. E., Drake, S. L., Iida, J., Knutson, J. R., and McCarthy, J. B., 1992, Mechanisms of normal cell adhesion to the extracellular matrix and alterations associated with tumor invasion and metastasis, Adv. Pathol. Lab. Med. 5:229–259.

    Google Scholar 

  • Faassen, A. E., Schrager, J. A., Klein, D. J., Oegema, T. R., Couchman, J. R., and McCarthy, J. B., 1992, A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen mediated melanoma cell motility and invasion, J. Cell Biol. 116:521–531.

    Article  PubMed  CAS  Google Scholar 

  • Faassen, A. E., Mooradian, D. L., Tranquillo, R. T., Dickinson, R. B., Letourneau, P. C., Oegema, T. R., and McCarthy, J. B., 1993, Cell surface CD-44 related chondroitin sulfate proteoglycan is required for transforming growth factor β-stimulated mouse melanoma cell motility and invasive behavior on type I collagen, J. Cell Science 105:501–511.

    PubMed  CAS  Google Scholar 

  • Gailit, J., and Clark, R. A. F., 1994, Wound repair in the context of the extracellular matrix, Curr. Opin. Cell Biol. 6(5):717–725.

    Article  PubMed  CAS  Google Scholar 

  • Ginsberg, M. H., Du, X., and Plow, E. F., 1992, Inside-out integrin signaling, Curr. Opin. Cell Biol. 4:766–771.

    Article  PubMed  CAS  Google Scholar 

  • Goldschmidt-Clermont, P. J., Kim, J. W., Machesky, L. M., Rhee, S.-G., and Pollard, T. D., 1991, Regulation of phospholipase C-g1 by profilin and tyrosine phosphorylation, Science 251:1231–1233.

    Article  PubMed  CAS  Google Scholar 

  • Grinnnell, F., Billingham, R. E., and Burgess, L., 1981, Distribution of fibronectin during wound healing in vivo, J. Invest. Dermatol 76:181–189.

    Article  Google Scholar 

  • Günthert, U., Hofmann, M., Rudy, W., Reber, S., Zöller, M., Hauβmann, I., Matzku, S., Wenzel, A., Ponta, H., and Herrlich, P., 1991, A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells, Cell 65:13–24.

    Article  PubMed  Google Scholar 

  • Hall, C. L., Wang, C., Lange, L. A., and Turley, E. A., 1994, Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity, J. Cell Biol 126:575–588.

    Article  PubMed  CAS  Google Scholar 

  • Hammarback, J. A., McCarthy, J. B., Palm, S. L., Furcht, L. T., and Letourneau, P. C., 1988, Growth cone guidance by substrate-bound laminin pathways is correlated with neuron-to-pathway adhesivity, Dev. Biol. 126(1):29–39.

    Article  PubMed  CAS  Google Scholar 

  • Hardwick, C., Hoare, K., Owens, R., Hohn, H. P., Höök, M., Moore, M., Cripps, V., Austen, L., Nance, D. M., and Turley, E. A., 1992, Molecular cloning of a novel hyaluronan receptor that mediated tumor cell motility, J. Cell Biol. 117:1343–1350.

    Article  PubMed  CAS  Google Scholar 

  • Harris, A. K., 1973, The behavior of cultured cells on substrata of various adhesiveness, Exp. Cell Res. 77:285–297.

    Article  PubMed  CAS  Google Scholar 

  • Harvath, L., 1990, Regulation of neutrophil chemotaxis: correlations with actin polymerization, Cancer Invest. 8:651–654.

    Article  PubMed  CAS  Google Scholar 

  • Hynes, R. O., 1992, Integrins: versatility, modulation, and signaling in cell adhesion, Cell 69:11–25.

    Article  PubMed  CAS  Google Scholar 

  • Iida, J., Milius, R. P., Oegema, T. R., Furcht, L. T., and McCarthy, J. B., 1994, Role of cell surface proteoglycans in tumor cell recognition of fibronectin, Trends Glycosc. Glycotechnol. 6:1–16.

    Article  CAS  Google Scholar 

  • Jalkanen, S., and Jalkanen, M., 1992, Lymphocyte CD44 binds the COOH-terminal heparin binding domain of fibronectin, J. Cell Biol. 116:817–825.

    Article  PubMed  CAS  Google Scholar 

  • Jamney, P. A., and Stossel, T. P., 1987, Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate, Nature 325:362–364.

    Article  Google Scholar 

  • Juliano, R. L., and Haskill, S., 1993, Signal transduction from the extracellular matrix, J. Cell Biol. 120:577–585.

    Article  PubMed  CAS  Google Scholar 

  • Kassner, P. D., and Hemler, M. E., 1993, Interchangeable a chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a β1 integrin, J. Exp. Med. 178:649–660.

    Article  PubMed  CAS  Google Scholar 

  • Kellie, S., Horvath, A. R., and Elmore, M. A., 1991, Cytoskeletal targets for oncogenic tyrosine kinases, J. Cell Sci. 99:207–211.

    PubMed  CAS  Google Scholar 

  • Knutson, J. R., Iida, J., Fields, G. B., and McCarthy, J. B., 1995, CD44/Chondroitin sulfate proteoglycan and α2β1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes, Mol. Biol. Cell, in press.

    Google Scholar 

  • Lassing, I., and Lindberg, V., 1985, Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilin, Nature 314:472–474.

    Article  PubMed  CAS  Google Scholar 

  • Laurent, T. C., and Fraser, J. R., 1992, Hyaluronan, FASEB J. 6:2397–2404.

    PubMed  CAS  Google Scholar 

  • Lennon, D. P., Carrino, D. A., Baber, M. A., and Caplan, A. I., 1991, Generation of a monoclonal antibody against avian small dermatan sulfate proteoglycan: immunolocalization and tissue distribution of PG-II (decorin) in embryonic tissues, Matrix 11(6):412–427.

    Article  PubMed  CAS  Google Scholar 

  • Lesley, J., and Hyman, R., 1992, CD44 can be activated to function as an hyaluronic acid receptor in normal murine T cells, J. Immunol. 22:2719–2723.

    CAS  Google Scholar 

  • Lesley, J., Hyman, R., and Kincade, P. W., 1993a, CD44 and its interaction with the cellular matrix, Adv. Immunol. 54:271–335.

    Article  PubMed  CAS  Google Scholar 

  • Lesley, J., Kincade, P. W., and Hyman, R., 1993b, Antibody-induced activation of the hyaluronan receptor function in CD44 requires multivalent binding by antibody, Eur. J. Immunol. 23:1902–1909.

    Article  PubMed  CAS  Google Scholar 

  • Liao, H. X., Levesque, M. C., Patton, K., Bergamo, B., Jones, D., Moody, M. A., Telen, M. J., and Haynes, B. F., 1993, Regulation of CD44H and CD44E isoform binding both hyaluronan by phorbol myristate acetate and anti-CD44 monoclonal and polyclonal antibodies, J. Immunol. 151:6490–6499.

    PubMed  CAS  Google Scholar 

  • Lindberg, F. P., Gresham, H. D., Schwartz, E., and Brown, E. J., 1993, Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane spanning domains implicated in avβ3 dependent ligand binding, J. Cell Biol. 123:485–496.

    Article  PubMed  CAS  Google Scholar 

  • Lokeshwar, V. B., and Borguignon, L. Y. W., 1991, Post-translational protein modification and expression of ankyrin-binding sites(s) in GP85 (Pgp-1/CD44) and its biosynthetic precursors during T-lymphoma membrane biosynthesis, J. Biol. Chem. 266:17983–17989.

    PubMed  CAS  Google Scholar 

  • Lokeshwar, V. B., Fregien, N., and Bourguignon, L. Y. W., 1994, Ankyrin-binding domain of CD44 (GP85) is required for the expression of hyaluronic acid-mediated adhesion function, J. Cell Biol. 126(4): 1099–1109.

    Article  PubMed  CAS  Google Scholar 

  • McCarthy, J., and Turley, E. A., 1993, Effects of extracellular matrix components on cell locomotion, Crit. Rev. Oral Biol. Med. 4:619–637.

    PubMed  CAS  Google Scholar 

  • Miyamoto, S., Akiyama, S. K., and Yamada, K. M., 1995, Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function, Science 267:883–885.

    Article  PubMed  CAS  Google Scholar 

  • Nelson, R. D., McCormack, R. T., and Fiegel, V. D., 1978, Chemotaxis of human leukocytes under agarose, in: Leukocyte Chemotaxis (J. I. Gallin and P. C. Quie, eds.), pp. 25–42, Raven Press, New York.

    Google Scholar 

  • O’Toole, T. E., Katagiri, Y., Faull, R. J., Peter, K., Quranta, V., Loftus, J. C., Shattil, S. J., and Ginsberg, M. H., 1994, Integrin cytoplasmic domains mediate inside-out signal transduction, J. Cell Biol. 124:1047–1059.

    Article  PubMed  Google Scholar 

  • Pasqualini, R., and Hemler, M. E., 1994, Contrasting roles for integrin β1 and β5 cytoplasmic domains in subcellular localization, proliferation and cell migration, J. Cell Biol. 125:447–460.

    Article  PubMed  CAS  Google Scholar 

  • Payrastre, B., Van Bergen en Henegouwen, P. M. P., Breton, M., den Hartigh, J. C., Plantavid, M., Verkleij, A. J., and Boonstra, J., 1991, Phosphoinositide kinase diacylglycerol kinase and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor, J. Cell Biol. 115:121–128.

    Article  PubMed  CAS  Google Scholar 

  • Peacock, E. E., and Van Winkle, W., 1976, Wound Repair. W. B. Saunders, Philadelphia.

    Google Scholar 

  • Pringle, G. A., Dodd, C. M., Osborn, J. W., Pearson, C. H., and Mosmann, T. R., 1985, Production and characterization of monoclonal antibodies to bovine proteodermatan sulfate, Collagen Related Res. 5:23–29.

    Article  CAS  Google Scholar 

  • Rapraeger, A., 1989, Transforming growth factor (type β) promotes the addition of chondroitin sulfate chains to the cell surface proteoglycan (syndecan) of mouse mammary epithelia, J. Cell Biol. 109:2509–2518.

    Article  PubMed  CAS  Google Scholar 

  • Repesh, L. A., Fitzgerald, T. J., and Furcht, L. T., 1982, Fibronectin involvement in granulation tissue and wound healing in rabbits, J. Histochem. Cytochem. 30:351–358.

    Article  PubMed  CAS  Google Scholar 

  • Ridley, A. J., Comoglio, P. M., and Hall, A., 1995, Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells, Mol. Cell. Biol. 15(2): 1110–1122.

    PubMed  CAS  Google Scholar 

  • Rudy, W., Hoffman, M., Schwartz-Albeiz, R., Zöller, M., Heider, K.-H., Ponta, H., and Herrlich, P., 1993, The two major CD44 proteins expressed on a metastatic rat tumor line are derived from different splice variants: each one individually suffices to confer metastatic behavior, Cancer Res. 53:1262–1268.

    PubMed  CAS  Google Scholar 

  • Samuel, S. K., Hurta, R. A., Spearman, M. A., Wright, J. A., Turley, E. A., and Greenberg, A. H., 1993, TGF-Beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan, J. Cell Biol. 123:749–758.

    Article  PubMed  CAS  Google Scholar 

  • Sastry, S. K., and Horwitz, A. F., 1993, Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra-and intracellular initiated transmembrane signaling, Curr. Opin. Cell Biol. 5:819–831.

    Article  PubMed  CAS  Google Scholar 

  • Schaller, M. D., and Parsons, J. T., 1994, Focal Adhesion Kinase and Associated Proteins, Curr. Opin. Cell Biol. 6(5):705–710.

    Article  PubMed  CAS  Google Scholar 

  • Schlaepfer, D. D., Hanks, S. K., Hunter, T., and van der Geer, P., 1994, Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase, Nature 372:786–791.

    PubMed  CAS  Google Scholar 

  • Scholzen, T., Solursh, M., Suzuki, S., Reiter, R., Morgan, J. L., Buchberg, A. M., Siracusa, L. D., and Iozzo, R. V., 1994, The murine decorin. Complete cDNA cloning, genomic organization, chromosomal assignment, and expression during organogenesis and tissue differentiation, J. Biol. Chem. 269(45):28270–28281.

    PubMed  CAS  Google Scholar 

  • Schonherr, E., Beavan, L. A., Hausser, H., Kresse, H., and Culp, L. A., 1993, Differences in decorin expression by papillary and reticular fibroblasts in vivo and in vitro, Biochem. J. 290(Pt 3):893–899.

    PubMed  Google Scholar 

  • Schwartz, M. A., 1993, Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium, J. Cell Biol. 120:1003–1010.

    Article  PubMed  CAS  Google Scholar 

  • Sherman, L., Sleeman, J., Herrlich, P., and Ponta, H., 1994, Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression, Curr. Opin. Cell Biol. 6(5):726–733.

    Article  PubMed  CAS  Google Scholar 

  • Shur, B. D., 1989, Glycoconjugates as mediators of cellular interactions during development, Curr. Opin. Cell Biol. 1:905–912.

    Article  PubMed  CAS  Google Scholar 

  • Stopak, D., and Harris, A. K., 1982, Connective tissue morphogenisis by fibroblast traction, Dev. Biol. 90:383–392.

    Article  PubMed  CAS  Google Scholar 

  • Stopak, D., Wessells, N. K., and Harris, A. K., 1985, Morphogenetic rerrangement of injected collagen in developing chicken limb buds, Proc. Natl. Acad. Sci. USA 82:2804–2808.

    Article  PubMed  CAS  Google Scholar 

  • Stossel, T. P., 1989, From signal to pseudopod formation. How cells control cytoplasmic actin assembly, J. Biol. Chem. 264:18261–18264.

    PubMed  CAS  Google Scholar 

  • Stossel, T. P., 1990, How cells crawl: with the discovery that the cellular motor contains muscle proteins, we can begin to describe cell motility in molecular detail, Sci.Amer. 78:408–423.

    Google Scholar 

  • Stossel, T. P., Chaponnier, C., Ezzell, R. M., Hartwig, J. H., Jamney, P. A., Kwiartkowski, D. J., and Lind, S. E., 1985, Non muscle actin binding proteins, Ann. Rev. Cell Biol. 1:353–402.

    Article  PubMed  CAS  Google Scholar 

  • Takaishi, K., Sasaki, T., Kato, M., Yamochi, W., Kuroda, S., Nakamura, T., Takeichi, M., and Takai, Y., 1994, Involvement of Rho p21 small GTP-binding protein and its regulator in the HGF-induced cell motility, Oncogene 9(1):273–279.

    PubMed  CAS  Google Scholar 

  • Trinkaus, J. P., 1976, On the mechanism of metazoan cell movements, in: The Cell Surface in Animal Embryogenisis and Development (G. Poste and G. J. Nicolson, eds.), pp. 225–329, North Holland, Amsterdam.

    Google Scholar 

  • Trinkaus, J. P., 1984, Cell into Organs. The Forces That Shape the Embryo. Prentice-Hall, Englewood Cliffs, N.J.

    Google Scholar 

  • Turley, E. A., 1992, Hyaluronan and cell locomotion, Cancer Metastasis Rev. 11:21–30.

    Article  PubMed  CAS  Google Scholar 

  • Turley, E. A., Austen, L., Vandeligt, K., and Clary, C., 1991, Hyaluronan and a cell-associated binding protein regulate the locomotion of ras-transformed cells, J. Cell Biol. 112:1041–1047.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, E. A., and Carter, W. G., 1987, Identification of multiple cell adhesion receptors for collagen and fibronectin in human fibrosarcoma cells possessing unique a and common β subunits, J. Cell Biol. 105:1873–1884.

    Article  PubMed  CAS  Google Scholar 

  • Wayner, E. A., and Carter, W. G., 1988, Characterization of the class III collagen receptor, a phosphorylated, transmembrane glycoprotein expressed in nucleated human cells, J. Biol. Chem. 263:4193–4201.

    PubMed  Google Scholar 

  • Wayner, E. A., Orlando, R. A., and Cheresh, D. A., 1991, Integrins avβ3 and avβ5 contribute to cell attachment to vitronectin but differentially distribute on the cell surface, J. Cell Biol. 113:919–929.

    Article  PubMed  CAS  Google Scholar 

  • Weiss, P., 1945, The problem of specificity in growth and development, Yale J. Biol. Med. 19:239–278.

    Google Scholar 

  • Weiss, P., 1985, Cell contact, Int. Rev. Cytol. 7:391–423.

    Article  Google Scholar 

  • Willen, M. D., Sorrell, J. M., Lekan, C. C., Davis, B. R., and Caplan, A. I., 1991, Patterns of glycosaminogly-can/proteoglycan immunostaining in human skin during aging, J. Invest. Dermatol. 96(6):968–974.

    Article  PubMed  CAS  Google Scholar 

  • Woods, A., and Couchman, J. R., 1992, Protein kinase C involvement in focal adhesion formation, J. Cell Sci. 101:277–290.

    PubMed  CAS  Google Scholar 

  • Yamada, K. M., Aota, S., Akiyama, S. K., and LaFlamme, S. E., 1992, Mechanisms of fibronectin and integrin function during cell adhesion and migration, Cold Spring Harbor Symp. Quant. Biol. 57:203–212.

    Article  PubMed  CAS  Google Scholar 

  • Yamagata, M., Shinomura, T., and Kimata, K., 1993, Tissue variation of two large chondroitin sulfate proteoglycans (PG-M/versican and PG-H/aggrecan) in chick embryos, Anat. Embryol. 187(5):433–444.

    Article  PubMed  CAS  Google Scholar 

  • Yang, B., Yang, B. L., Savani, R. C., and Turley, E. A., 1994, Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and Link Protein, EMBO J. 13:286–296.

    PubMed  Google Scholar 

  • Yeo, T. K., Brown, L., and Dvorak, H. F., 1991, Alterations in proteoglycan synthesis common to healing wounds and tumors, Am. J. Pathol. 138(6):1437–1450.

    PubMed  CAS  Google Scholar 

  • Zigmond, S. H., 1977, Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors, J. Cell Biol. 75:606–616.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S. H., 1989, Cell locomotion and chemotaxis, Curr. Opin. Cell Biol. 1:80–86.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S. H., and Hirsch, J. G., 1973, Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors, J. Exp. Med. 137:387–410.

    Article  PubMed  CAS  Google Scholar 

  • Zigmond, S. H., Levitsky, H. I., and Kreel, B. J., 1981, Cell polarity: An examination of its behavior expression and its consequences for polymorphonuclear leukocyte chemotaxis, J. Cell Biol. 89:585–592.

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann, D. R., Dours-Zimmermann, M. T., Schubert, M., and Bruckner-Tuderman, L., 1994, Versican is expressed in the proliferating zone in the epidermis and in association with the elastic network of the dermis, J. Cell Biol. 124(5):817–825.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Laboratory Medicine and Pathology, Biomedical Engineering Center, University of Minnesota, Minneapolis, Minnesota, 55455, USA

    James B. McCarthy, Joji Iida & Leo T. Furcht

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  1. James B. McCarthy
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  1. Department of Dermatology, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York, 11794-8165, USA

    Richard A. F. Clark

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McCarthy, J.B., Iida, J., Furcht, L.T. (1988). Mechanisms of Parenchymal Cell Migration into Wounds. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_12

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