Abstract
Reepithelialization is the term used in common parlance to indicate the covering of a skin wound with a new epithelium. In clinical practice, this term is truly ill-defined and usually does not take into account the complexity and specialty cells of an unwounded, mature, human epidermal layer. In the examination of a healed or healing wound, the clinician often says that the wound is “reepithelialized” if the moist erythematous vascular granulation bed is covered by a dry film of epithelium. At the clinical level, the physician usually does not take into account other functions of this epithelial membrane such as its immune function directed by epidermal Langerhan’s cells, the role of pigment-producing melanocytes, the sensory function of epithelial Merkel’s cells, the barrier function of an organized and mature stratum corneum, and the stable epidermal-dermal adherence that occurs by a fully formed neobasement membrane zone between the epidermis and the underlying neodermis. In the future, as we advance our abilities to measure these functions, it is hoped that the definition of reepithelialization on the clinical level will undergo more refinement and discrimination.
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References
Bauer, E. A., 1977, Cell culture density as a modulator of collagenase expression in normal human fibroblast cultures, Exp. Cell Res. 107:209–276.
Bauer, E. A., Gordon, J. M., Reddick, M. E., and Eisen, A. Z., 1977, Quantitation and immunocytochemical localization of human skin collagenase in basal cell carcinoma, J. Invest. Dermatol. 69:363–367.
Bereiter-Hahn, J., Strohmeier, R., Kunzenbacher, I., Beck, K., and Voth, M., 1981, Locomotion of Xenopus epidermis cells in primary culture, J. Cell. Sci. 52:289–311.
Brown, C., Stenn, K. S., Falk, R. J., Woodley, D. T., and O’Keefe, E. J., 1991, Vitronectin: Effects on keratinocyte motility and inhibition of collagen-induced motility, J. Invest. Dermatol. 96:724–728.
Brown, G. L., Nanney, L. B., Griffen, J., Cramer, A. B., Yancey, J. M., Curtsinger, III, L. J., Holtzin, L., Schultz, G. S., Jurkiewicz, M. J., and Lynch, J. B., 1989, Enhancement of wound healing by topical treatment with epidermal growth factor, N. Engl. J. Med. 321:76–79.
Carter, W. G., Ryan, M. C., and Gahn, P. J., 1991, Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes, Cell 65:599–610.
Ceilley, E., Watanabe, N., Shapiro, D., Verrando, P., Bauer, E. A., Burgeson, R., Briggaman, R. A., and Woodley, D. T., 1993, Labeling of fractured human skin with antibodies to BM 600/nicein, epiligrin, kalinin and other matrix components, J. Dermatol. Sci. 5:97–103.
Chen, J. D., Kim, J. P., Zhang, K., Sarret, Y., Wynn, K. C., Kramer, R. H., and Woodley, D. T., 1993a, Epidermal growth factor (EGF) promotes human keratinocyte locomotion on collagen by increasing the α2 integrin subunit, Exp. Cell Res. 209:216–223.
Chen, J. D., Langhofer, M., Iwasaki, T., Kim, Y. H., Jones, J. C. R., Krueger, J. G., Carter, D. M., and Woodley, D. T., 1993b, Junctional epidermolysis bullosa (JEB) keratinocytes fail to secrete hemidesmo-some (HD)-associated matrix elements and demonstrate enhanced locomotion, J. Invest. Dermatol. 11(4): 170 (Abstract).
Chen, J. D., Lapierre, J.-C., Sauder, D., Peavey, C., and Woodley, D. T., 1995, Interleukin-1 alpha stimulates keratinocyte migration through an EGF/TGF-alpha independent pathway, J. Invest. Dermatol. 104:729–733.
Clark, R. A. F., Lanigan, J. M., DellaPelle, P., Manseau, E., Dvorak, H. F., and Colvin, R. B., 1982, Fibronectin and fibrin provide a provisional matrix for epidermal cell migration during wound reep-ithelialization, J. Invest. Dermatol. 79:264–269.
Clark, R. A. F., Folkvord, J. M., and Wertz, R. L., 1985, Fibronectin, as well as other extracellular matrix proteins, mediate human keratinocyte adherence, J. Invest. Dermatol. 85:368–383.
Colman, G. J., and Roenigk, H. H., 1978, Topical therapy of leg ulcers with 20 percent benzoyl peroxide lotion, Cutis 21:491–494.
Cornelius, L. A., Woodley, D. T., Cronce, D. J., and Briggaman, R. A., 1986, Dermal-epidermal junction reformation following human skin wounding studied by correlative ultrastructural and immunochemical techniques, J. Invest. Dermatol. 86:469 (Abstract).
Diaz, L. A., Ratrie, H., Saunders, W. S., Futamura, S., Squiquera, H. R., Anhalt, G. J., and Guidice, G. J., 1990, Isolation of a human epidermal cDNA corresponding to the 180 kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocaliazation of this protein to the hemidesmo-some, J. Clin. Invest. 86:1088–1094.
DiPasquale, A., 1975, Locomotion of epithelial cells, Exp. Cell Res. 95:425–439.
Donaldson, D. J., and Mahan, J. T., 1983, Fibrinogen and fibronectin on substrates from epidermal cell migration during wound closure, J. Cell Sci. 62:117–123.
Donaldson, D. J., and Mahan, J. T., 1984, Influence of catecholamines on epidermal cell migration during wound closure in adult newts, Comp. Biochem. Physiol. 78C:267–270.
Duband, J. L., Nuckolls, G. H., Ishihara, A., Hasegawa, T., Yamada, K. M., Thiery, J. P., and Jacobson, K., 1988, Fibronectin receptor exhibits high lateral motility in embryonic locomoting cells but is immobile in focal contacts and fibrillar streaks in stationary cells, J. Cell Biol. 107:1385–1396.
Dunlap, M. K., 1980, Cyclic AMP levels in migrating and non-migrating newt epidermal cells, J. Cell. Physiol. 104:367–373.
Dunlap, M. K., and Donaldson, D. J., 1978, Inability of colchicine to inhibit newt epidermal cell migration or prevent concanavalin A-mediated inhibition of migration studies in vivo, Exp. Cell Res. 116:15–19.
Eaglstein, W. H., Davis, S. C., Mehle, A. L., and Mertz, P. M., 1988, Optimal use of an occlusive dressing to enhance healing, Arch. Dermatol. 124:392–395.
Falanga, V., Katz, M. H., and Alvarez, A. F., 1991, Dibutryl cyclic AMP by itself or in combination with growth factors can stimulate or inhibit growth of human keratinocytes or dermal fibroblasts, Wounds 3:70–78.
Fritsch, P., Tappeiner, G., and Huspek, G., 1979, Keratinocyte substrate adhesion is magnesium-dependent and calcium independent, Cell Biol. Int. Rep. 3:593–598.
Gabbiani, G., Chaponnier, C., and Huttner, I., 1978, Cytoplasmic filament and gap functions in epithelial cells and myofibroblasts during wound healing, J. Cell Biol. 76:561–568.
Gailit, J., Welch, M. P., and Clark, R. A. F., 1994, TGF-β1 stimulates expression of keratinocyte integrins during re-epithelialization of cutaneous wounds, Invest. Dermatol. 103:221–227.
Gentzkow, G. D., Alon, G., Taler, G., Eltorai, I., and Montray, R., 1993, Healing of refractory stage III and IV pressure ulcers by a new electrical stimulation device, Wounds 5(3): 160–172.
Gibbins, J. R., 1972, Metabolic requirements for epithelial migration as defined by the use of metabolic inhibitors in organ culture, Exp. Cell Res. 71:329–337.
Gibbins, J. R., 1973, Epithelial migration in organ culture. Role of protein synthesis as determined by metabolic inhibitors, Exp. Cell Res. 80:281–290.
Gilchrest, B. A., Nemore, R. E., and Maciag, T., 1980, Growth of human keratinocytes on fibronectin-coated plates, Cell Biol. Int. Rep. 4:1009–1016.
Gipson, I. K., and Anderson, R. A., 1980, Effect of lectin on migration of the corneal epithelium, Invest. Ophthalmol. Vis. Sci. 19:341–349.
Gipson, I. K., and Kiorpes, T. C., 1982, Epithelial sheet movement: Protein and glycoprotein synthesis, Dev. Biol. 92:259–262.
Gipson, I. K., Westcott, M. J., and Brooksby, N. G., 1982, Effects of cytochalasins B and D and colchicine on migration of the corneal epithelium, Invest. Ophthal. Vis. Sci. 22:633–642.
Guidice, G., Squiquera, H. L., Elias, P. M., and Diaz, L. A., 1991, Identification of two collagen domains within the bullous pemphigoid autoantigen, BP180, J. Clin. Invest. 87:734–738.
Haymen, E. G., Pierschbacher, M. D., Suzuki, S., and Ruoslahti, E., 1985, Vitronectin: A major cell attachment-promoting protein in filal bound serum, Exp. Cell. Res. 160:245–258.
Hebda, P. A., 1988, Stimulatory effects of transforming growth factor beta and epidermal growth factor on epidermal cell outgrowth from porcine skin expiant cultures, J. Invest. Dermatol. 91:440–445.
Hebda, P. A., Klingbeil C., Abraham J., and Fiddes, J. C., 1988, Acceleration of epidermal wound healing by human basic fibroblast growth factor, J. Invest. Dermatol. 90:568a.
Hintner, H., Fritsch, P. O., Foidart, T. M., Stingl, G., Schuler, G., and Katz, S. I., 1980, Expression of basement membrane zone antigens at the dermo-epibolic junction in organ cultures of human skin, J. Invest. Dermatol. 74:200–204.
Iwasaki, T., Kim, J. P., Wynn, K. C., and Woodley, D. T., 1994, Dibutryl cyclic AMP modulates keratinocyte locomotion, J. Invest. Dermatol. 102:891–897.
Kim, J. P., Chen, J. D., and Woodley, D. T., 1992a, Mechanism of human keratinocyte migration on fibronectin: Unique roles of RGD site and integrins, J. Cell. Physiol. 151:443–450.
Kim, J. P., Zhang, K., Kramer, R. H., Schall, T. J., and Woodley, D. T., 1992b, Integrin receptors and RGD sequences in human keratinocyte migration: Unique anti-migratory function of α3β1, J. Clin. Invest. 98:764–770.
Kim, Y. H., Kim, J. P., Chen, J. D., Iwasaki, T., Hernandez, G., Saraf, P., Bauer, E. A., and Woodley, D. T., 1993, Biologic characteristics of recessive dystrophic epidermolysis bullosa (RDEB) keratinocytes, J. Invest. Dermatol. 11(4):551 (Abstract).
Kim, J. P., Schall, T. J., Kleinman, H. K., and Woodley, D. T., 1994a, Human keratinocyte migration on type IV collagen: Unique roles of heparin binding site and integrins, Lab. Invest. 71:401–408.
Kim, J. P., Zhang, K., Chen, J. D., Kramer, R. H., and Woodley, D. T., 1994b, Vitronectin-driven human keratinocyte locomotion is mediated the αvβ5 integrin receptor, J. Biol. Chem. 43:26926–26932.
Kono, I., Matsumoto, Y., Kano, K., Yasuhisa, I., Narushima, K., Kabashima, T., Yamane, K., Sakurai, T., and Kashiwagi, H., 1985, Beneficial effect of topical fibronectin in patients with keratoconjunctivitis sicca of Sjorgren’s syndrome, J. Rheumatol. 12:487–489.
Kubo, M., Noms, D. A., Howell, S. E., and Clark, R. A. F., 1984, Human keratinocytes synthesize, secrete and deposit fibronectin in the pericellular matrix, J. Invest. Dermatol. 82:580–586.
Kupper, T. S., Ballard, D. W., Chua, A. O., McGuire, J. S., Flood, P. M., Horowitz, M. C., Langdon, L., and Gubler, V., 1986, Expression of mRNA homologous to interleukin-1 in human epidermal cells, J. Exp. Med. 64:2095–2098.
Kuwabara, T., Perkins, D. G., and Cogan, D. G., 1976, Sliding of the epithelium in experimental corneal wounds, Invest. Ophthalmol. 15:4–14.
Liotta, L. A., Siegeto, A., Gebron-Robey, P., and Martin, A. K., 1979, Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic tumor, Proc. Natl. Acad. Sci. USA 76:2268–2272.
Luger, T. A., Stadler, B. M., Katz, S. I., and Oppenheimer, J. J., 1981, Epidermal cell derived thymocyte activating factor (ETAF), J. Immunol. 127:1493–1498.
Lyon, R. A., and Reynolds, T. E., 1929, Promotion of healing by benzoyl peroxide and other agents, Proc. Soc. Exp. Biol. Med. 27:122–151.
Marinkovich, M. P., Peavey, C. L., Burgeson, R. E., and Woodley, D. T., 1994, Kalinin inhibits collagen-driven human keratinocyte migration, J. Clin. Invest. 102(4): 157 (Abstract).
Mertz, P., Davis, C., Cazzaniga, A., Cheng, K., Reich, J., and Eaglstein, W., 1993, Electrical stimulation: Acceleration of soft tissue repair by varying the polarity, Wounds 5(3): 153–159.
Mustoe, T. A., Pierce, G. F., Thomason, A., Sporn, M., Gramates, P. H., and Deuel, T. F., 1987, Accelerated healing of incisional wounds in rats induced by transforming growth factor β, Science 237:1333–1335.
Mutasim, D. F., Takahashi, Y., Ramzy, L. S., Anhalt, G. J., Patel, H. P., and Diaz, L. A., 1985, A pool of bullous pemphigoid antigen(s) is intracellular and associated with the basal cell cytoskeleton-hemidesmosome complex, J. Invest. Dermatol. 84:47–53.
Nishida, T., Nakagawa, S., and Manabe, R., 1985, Clinical evaluation of fibronectin eye drops on epithelial disorders after herpetic keratitis, Ophthalmology 92:213–216.
Ödland, G., and Ross, R., 1968, Human wound repair. I Epidermal regeneration, J. Cell Biol. 39:135–151.
O’Keefe, E. J., Woodley, D., Castillo, G., Russell, N., and Payne, R. E., 1984, Production of soluble and cell associated fibronectin by cultured keratinocytes, J. Invest. Dermatol. 82:150–155.
O’Keefe, E. J., Payne, R. E., Russell, N., and Woodley, D. T., 1985, Spreading and enhanced motility of human keratinocytes on fibronectin, J. Invest. Dermatol. 85:125–130.
O’Keefe, E. J., Chiu, M. L., and Payne, R. E., 1988, Stimulation of growth of keratinocytes by basic fibroblast growth factor, J. Invest. Dermatol. 90:767–769.
Peavey, C. L., Ladin, D. A., Mustoe, T. A., and Woodley, D. T., 1994, Hypoxia stimulates human keratinocyte migration on interstitial collagen, J. Clin. Invest. 102(4):699 (Abstract).
Petersen, M. J., Woodley, D. T., Stricklin, G. P., and O’Keefe, E. J., 1989, Constitutive production of procollagenase and collagenase inhibitor by human keratinocytes in culture, J. Invest. Dermatol. 92:156–159.
Petersen, M. J., Woodley, D. T., Stricklin, G. P., and O’Keefe, E. J., 1990, Enhanced synthesis of collagenase by human keratinocytes cultured on type I or type IV collagen, J. Invest. Dermatol. 94:341–346.
Postlethwaite, A. E., Lachman, L. B., Mainardi, C. L., and Kang, A. H., 1982, Interleukin I stimulation of collagenase production by cultured fibroblasts, J. Exp. Cell Biol. 157:801–806.
Rao, C. N., Ladine, D., Liu, Y., Hou, Z., Chilukuri, K., and Woodley, D. T., 1995, Alpha 1 antitypsin is degraded and non-functional in chronic wounds: The inhibitor protects fibronectin from degradation by chronic wound fluid enzymes, J. Invest. Dermatol. in press.
Regnier, M., Prunieras, M., and Woodley, D., 1981, Growth and differentiation of adult human epidermal cells on dermal substrate, Front. Matrix Biol. 9:4–32.
Robledo, M. A., Kim, S.-C., Korman, N. J., Stanley, J. R., Labib, R. S., Futamura, S., and Anhalt, G. J., 1990, Studies of the relationship of the 230 kD and 180 kD bullous pemphigoid antigens, J. Invest. Dermatol. 94:793–797.
Rocha, V., Horn, Y. K., and Marinkovich, M. P., 1986, Basal lamina inhibition suppresses synthesis of calcium-dependent proteins associated with mammary epithelial cell spreading, Exp. Cell Res. 165:450–460.
Rousselle, P., Lunstrum, G. P., Keene, D. R., and Burgeson, R. E., 1991, Kalinin: An epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments, J. Cell Biol. 114:567–576.
Ruoslahti, E., and Pierschbacher, M. D., 1987, New perspectives in cell adhesion: RGD and integrins, Science 238:491–497.
Ruoslahti, E., Engvall, E., and Hayman, E. G., 1981, Fibronectin: Current concepts of its structure and function, Coll. Res. 1:95–128.
Sarret, Y., Kleinman, H. K., and Woodley, D. T., 1991, The peptide (CSIKVAVS-NH2) near the amino terminus of the laminin A chain markedly inhibits human keratinocyte locomotion, Clin. Res. 39(2):514A (Abstract).
Sarret, Y., Raftery, K., and Woodley, D. T., 1992a, Intracellular and extracellular calcium levels dramatically alter human keratinocyte migration, J. Invest. Dermatol. 98(4):572 (Abstract).
Sarret, Y., Woodley, D. T., Grigsby, K., Wynn, K. C., and O’Keefe, E. J., 1992b, Human keratinocyte locomotion: The effect of selected cytokines, J. Invest. Dermatol. 98:12–16.
Sauder, D. N., Carter, C., Katz, S. I., and Oppenheim, J. J., 1982, Epidermal cell production of thymocyte activating factor (ETAF), J. Invest. Dermatol. 79:34–39.
Sauder, D. N., Stanulis-Prager, B. M., and Gilchrist, B. A., 1988, Autocrine growth stimulation of human keratinocytes by epidermal cell derived thymocyte activating factor, Arch. Dermatol. Res. 280:71–78.
Schaumburg-Lever, G., Rule, R. A., Schmidt-Ullrich, B., and Lever, W. F., 1975, Ultrastructural localization of in vivo bound immunoglobulins in bullous pemphigoid: A preliminary report, J. Invest. Dermatol. 64:47–49.
Scheel, G., Rahsoth, B., Franke, J., and Grau, P., 1991, Acceleration of wound healing by local application of fibronectin, Arch. Orthop. Trauma Surg. 110:284–287.
Stanley, J. R., Alvarez, O. M., Bere, E. W., Eaglstein, W. H., and Katz, S. I., 1981, Detection of membrane zone antigens during epidermal wound healing in pigs, J. Invest. Dermatol. 7:240–243.
Stanley, J. R., Woodley, D. T., Katz, S. I., and Martin, G. R., 1982a, Structure and function of basement membrane, J. Invest. Dermatol. 79:69s–72s.
Stanley, J. R., Hawley-Nelson, P., Yaar, M., Martin, G. R., and Katz, S. I., 1982b, Laminin and bullous pemphigoid antigen are distinct basement membrane proteins synthesized by epidermal cells, J. Invest. Dermatol. 78:456–459.
Stanley, J. R., Tanaka, T., Mueller, S., Klaus-Kouan, V., and Roop, D., 1988, Isolation of complementary DNA for bullous pemphigoid antigen by use of patients’ autoantibodies, J. Clin. Invest. 82:1864–1870.
Stenn, K. S., 1978, The role of serum in the epithelial outgrowth of mouse skin expiants, Br. J. Dermatol. 98:411–416.
Stenn, K. S., 1981, Epibolin: A protein of human plasma which supports epithelial cell movement, Proc. Natl. Acad. Sci. USA 78:6907–6911.
Stenn, K. S., 1987, Coephibolin, the activity of human serum that enhances the cell-spreading properties of epibolin, associates with albumin, J. Invest. Dermatol. 89:59–63.
Stenn, K. S., and Core, N. G., 1986, Calton dependence of guinea pig epidermal cell spreading, In Vitro Cell. Dev. Biol. 22:217–222.
Stenn, K. S., and Depalma, L., 1988, Re-epithelialization, in: The Molecular and Cellualr Bilolgy of Wound Repair, 1st ed. (R. A. F. Clark and P. M. Hensen, eds.), pp. 321–325, Plenum Press, New York.
Stenn, K. S., and Dvoretzky, I., 1979, Human serum and epithelial spread in tissue culture, Arch. Dermatol. Res. 246:3–15.
Stenn, K. S., Madri, J. A., and Roll, F. J., 1979, Migrating epidermis produces AB2 collagen and requires continual collagen synthesis for movement, Nature 277:229–232.
Takashima, A., and Grinnell, F., 1984, Human keratinocyte adhesion and phagocytosis promoted by fibronectin, J. Invest. Dermatol. 83:352–358.
Varghese, M. C., Balin, A. K., Carter, M., and Caldwell, D., 1986, Local environment of chronic wounds under synthetic dressings, Arch. Dermatol. 122:52–56.
Verrando, P., Hsi, B. L., Yeh, C.-J., Pisani, A., Serieys, N., and Ortonne, J.-P., 1987, Monoclonal antibody GB3, a new probe in the study of human basement membranes and hemidesmosomes, Exp. Cell Res. 170:116–128.
Westgate, G. E., Weaver, A. C., and Couchman, J. R., 1985, Bullous pemphigoid antigen localization suggests an intracellular association with hemidesmosomes, J. Invest. Dermatol. 84:218–224.
Wilke, M. S., and Furcht, L. T., 1990, Human keratinocytes adhere to a unique heparin-binding peptide sequence within the triple helical domain of type IV collagen, J. Invest. Dermatol. 95:264–270.
Winter, G. D., 1962, Formation of the scab and the rate of epithelialization of superficial wounds in the skin of the young domestic pig, Nature 193:293–294.
Woodley, D. T., and Kim, Y. H., 1992, A double-blind comparison of wound dressings using uniform suction blister wounds, Arch. Dermatol. 128:1354–1357.
Woodley, D. T., Didierjean, L., Regnier, M., Saurat, J., and Prunieras, M., 1980a, Bullous pemphigoid antigen synthesized in vitro by human epidermal cells, J. Invest. Dermatol. 75:148–151.
Woodley, D. T., Regnier, M., and Prunieras, M., 1980b, In vitro basal lamina formations may require non-epidermal cell living substrate, Br. J. Dermatol. 103:397–404.
Woodley, D. T., Rao, C. N., Hassell, J. R., Liotta, L. A., Martin, G. R., and Kleinman, H. K., 1983, Interactions of basement membrane components, Biochim. Biophys. Acta 761:278–283.
Woodley, D. T., O’Keefe, E. J., and Prunieras, M., 1985a, Cutaneous wound healing: A model for cell-matrix interactions, J. Am. Acad. Dermatol. 12:420–433.
Woodley, D. T., Briggaman, R. A., Gammon, W. R., and O’Keefe, E. J., 1985b, Epidermolysis bullosa acquisita antigen is synthesized by human keratinocytes cultured in serum-free medium, Biochem. Biophys. Res. Commun. 130:1267–1272.
Woodley, D. T., Kelebec, T., Banes, A. J., Link, W., Prunieras, M., and Liotta, L. A., 1986, Adult human keratinocytes migrating over nonviable dermal collagen produce collagenolytic enzymes that degrade type I and type IV collagen, J. Invest. Dermatol. 86:418–423, 1986.
Woodley, D. T., O’Keefe, E. J., McDonald, J. A., 1987, Specific affinity between fibronectin and the epidermolysis bullosa acquisita antigen, J. Clin. Invest. 179:1826–1830.
Woodley, D. T., Bachmann, P. M., and O’Keefe, E. J., 1988a, Laminin inhibits human keratinocyte migration, J. Cell. Physiol. 136:140–146.
Woodley, D. T., Peterson, H. D., Herzog, S. R., Stricklin, G. P., Burgeson, R. E., Briggaman, R. A., Cronce, D. J., and O’Keefe, E. J., 1988b, Burn wounds resurfaced by cultured epidermal autografts show abnormal reconstitution of anchoring fibrils, J. Am. Med. Assoc. 259:2566–2571.
Woodley, D. T., Briggaman, R. A., Herzog, S., Meyers, A., Peterson, H. D., and O’Keefe, E. J., 1990a, Characterization of neo-dermis formation beneath cultured human epidermal autografts transplanted on muscle fascia, J. Invest. Dermatol. 95:20–26.
Woodley, D. T., Wynn, K. C., and O’Keefe, E. J., 1990b, Type IV collagen and fibronectin enhance human keratinocyte thymidine incorporation, J. Invest. Dermatol. 94:139–143.
Wysocki, A., Baxter, C. R., Bergstresser, P. R., Grinnell, F., Horowitz, M. S., and Horowitz, B., 1988, Topical fibronectin therapy for treatment of a patient with chronic status ulcers, Arch. Dermatol. 124:175–177.
Wysocki, A. B., and Grinnell, F., 1990, Fibronectin profiles in normal and chronic wound fluid, Lab. Invest. 63:825–831.
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Woodley, D.T. (1988). Reepithelialization. In: Clark, R.A.F. (eds) The Molecular and Cellular Biology of Wound Repair. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0185-9_10
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