Abstract
We describe Monte Carlo codes that simulate, event by event, the interaction of energetic electrons with a double-stranded DNA molecule and with the condensed water surrounding it. Both direct and indirect effects are treated explicitly. The cross-sectional input necessary in the transport codes was obtained via quantum-mechanical calculations of the dielectric response function, ε(q,ω), of polycytidine. For each inelastic event on DNA we score the energy deposited locally, the position of the event and the moiety that underwent that event. This information provides a detailed picture of the spatial disposition of molecular alterations for DNA exposed to ionizing radiation.
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References
J.F. Ward, Biochemistry of DNA lesions, Radiat. Res. 104: S103 — S111 (1985).
H.G. Paretzke and M.J. Berger, Stopping power and energy degradation for electrons in water vapor, in: (ed): 6th symp. on microdosimetry, Brussels,London: Harwood Academic Publishers,CEC, pp. 749–58 (1978).
J.E. Turner, R.N. Hamm, H.A. Wright, J.T. Modolo, and G.M.A.A. Sardi, Monte Carlo calculations of initial energies of Compton electrons and photoelectrons in water irradiated by photons with energies up to 2 MeV, Health Phys. 39: 49–55 (1980).
M. Zaider, D.J. Brenner and W.E. Wilson, The application of track calculations to radiobiology.-I. Monte Carlo simulation of proton tracks, Radiat. Res. 95: 231–247 (1983).
J.E. Turner, H.G. Paretzke, R.N. Hamm, H.A. Wright, and R.H. Ritchie, Comparative study of electron energy deposition and yields in water in the liquid and vapor phases, Radiat. Res. 92: 47–60 (1982).
M. Zaider, M.G. Vracko, A.Y.C. Fung, and J.L. Fry, Electron transport in condensed water, Radiat. Prot. Dos. 52: 139–146 (1994).
D.E. Charlton, H. Nikjoo, and J.L. Humm, Calculation of initial yields of single-and double-strand breaks in cell nuclei from electrons, protons and alpha particles, Int. J. Radiat. Biol. 56: 1–19 (1989).
M. Bardash and M. Zaider, A stochastic treatment of radiation damage to DNA from indirect effects, Radiat. Prot. Dos. 51: 171–176 (1994).
P. Schattschneider, “Fundamentals of Inelastic Electron Scattering,” Springer Verlag, New York (1986).
M.W. Williams and E.T. Arakawa, Optical and dielectric properties of materials relevant to biological research, in: “Handbook on Synchrotron Radiation,” Elsevier, New York (1990).
D. Pines and P. Nozieres, “The Theory of Quantum Liquids,” Benjamin, New York (1966).
L. Hedin and S. Lundqvist, Effects of electron-electron and electron-phonon interactions on the one-electron states of solids, Solid State Phys. 23: 1–181 (1969).
F. Bassani, G. Pastori Parravicini, and R.A. Ballinger, Electronic states and optical transitions in solids, Pergamon Press (1975).
F.C. Bernstein, T.F. Koetzle, G.J.B. Williams, E.F. Meyer, M.D. Brice, J.R. Rodgers, O. Kennard, T. Shimanouchi, and M. Tasumi, The protein data bank: a computer based archival file for macromolecular structures, J. Mol. Biol. 112: 535–542 (1977).
T. Inagaki, R.N. Hamm, E.T. Arakawa, and L.R. Painter, Optical and dielectric properties of DNA in the extreme ultrviolet, J. Chem. Phys. 61: 4246–4250 (1974).
R.H. Ritchie and J.C. Ashley, The interaction of hot electrons with a free electron gas, J. Phys. Chem. Solids 26: 1689–1694 (1965).
M.G. Vracko and M. Zaider, A study of the excited states in cytosine and guanine stacks in the HartreeFock and exciton approximations, Radiat. Res. 138: 18–25 (1994).
C. Von Sonntag. “The Chemical Basis of Radiation Biology,” Taylor Francis, Philadelphia (1987).
C.D. Jonah, M.S. Matheson, J.R. Miller, and E.J. Hart, Yield and decay of the hydrated electron from 100 ps to 3 ns, J. Phys. Chem. 80: 1267–70 (1976).
A.M. Kellerer and D. Chmelevsky, Concepts of microdosimetry. III. Mean values of the microdosimetric distributions, Radiat. Environ. Biophys. 12: 321–335 (1975).
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© 1994 Springer Science+Business Media New York
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Zaider, M., Fung, A., Bardash, M. (1994). Charged-Particle Transport in Biomolecular Media: The Third Generation. In: Varma, M.N., Chatterjee, A. (eds) Computational Approaches in Molecular Radiation Biology. Basic Life Sciences, vol 63. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9788-6_7
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DOI: https://doi.org/10.1007/978-1-4757-9788-6_7
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