Abstract
Vale and his colleagues (1989) devised a method of attaching single dynein molecules to a substrate and observing the motion of microtubules. In one series of experiments they inhibited the enzymatic activity of the dynein with vanadate. By fitting a Gaussian to this data, they obtained the diffusion constants shown in Table 1. However, according to the theoretical formulas for longitudinal and transverse diffusion of a cylinder these diffusion constants should be much larger. (The longitudinal and transverse diffusion coefficients are given by the following expressions: D L = kTln(2h/r)/2πηL and D T = kTln(2h/r)/4πηL (Brennen and Winet, 1977)). This discrepancy suggests two models for the interaction.
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References
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© 1991 Springer Science+Business Media New York
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Cordova, N.J., Vale, R.D., Oster, G.F. (1991). Dynein-Microtubule Interactions. In: Peliti, L. (eds) Biologically Inspired Physics. NATO ASI Series, vol 263. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9483-0_19
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DOI: https://doi.org/10.1007/978-1-4757-9483-0_19
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