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Fertilization in Dogs

  • Chapter
A Comparative Overview of Mammalian Fertilization

Abstract

Most knowledge of the basic reproductive biology of companion animals such as the dog has been derived from studies directed at developing contraceptive technologies to combat overpopulation of pets. The bitch has been used as a model in the study of some steroid hormones (El Etreby et al., 1979; Frank et al., 1979), and the male dog has been used extensively in studies of prostate function (Huggins, 1945). In addition, spermatozoa of the dog have been used in studies of sperm metabolism and motility (Wales and White, 1958; Tash et al., 1986, 1988). However, there are numerous unique aspects of canine reproductive biology that make the dog worthy of study for its own sake even though these same aspects make the use of the dog as a model for human reproductive biology questionable. Furthermore, a more complete study of fertilization in the dog is indicated by the need for effective contraceptive technology for this species (Mahi-Brown, 1986).

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References

  • Andersen, A. C., and Simpson, M. E., 1973, The Ovary and Reproductive Cycle of the Dog (Beagle), Geron-X, Inc., Los Altos.

    Google Scholar 

  • Andersen, K., 1974, Intrauterine insemination with frozen semen in dogs, in: Proceedings 12th Nordic Veterinary Congress, Reykjavik, Iceland, pp. 153–154.

    Google Scholar 

  • Bischoff, T. L. W, 1845, Entwicklungsgeschichte des Hunde-Eies, Friedrich Vieweg and Sohn, Braunschweig.

    Google Scholar 

  • Boucher, J. H., Foote, R. H., and Kirk, R. W, 1958, The evaluation of semen quality in the dog and the effects of frequency of ejaculation upon semen quality, libido, and depletion of sperm reserves, Cornell Vet. 48: 67–86.

    PubMed  CAS  Google Scholar 

  • Bowen, R. A., 1977, Fertilization in vitro of feline ova by spermatozoa from the ductus deferens, Biol. Reprod. 17: 144–147.

    Article  PubMed  CAS  Google Scholar 

  • Brinster, R. L., 1965a, Studies on the development of mouse embryos in vitro. I. The effect of osmolality and hydrogen ion concentration, J. Exp. Zool. 158: 49–58.

    Article  PubMed  CAS  Google Scholar 

  • Brinster, R. L., 19656, Studies on the development of mouse embryos in vitro. II. The effect of energy source, J. Exp. Zool. 158: 59–68.

    Google Scholar 

  • Brinster, R. L., 1965c, Studies on the development of mouse embryos in vitro. III. The effect of fixed nitrogen source, J. Exp. Zool. 158: 69–78.

    Article  PubMed  CAS  Google Scholar 

  • Brinster, R. L., 1965d, Studies on the development of mouse embryos in vitro. IV. Interaction of energy sources, J. Reprod. Fertil. 10: 227–240.

    Article  PubMed  CAS  Google Scholar 

  • Cain, J. L., Cain, G. R., Feldman, E. C., Lasley, B. L., and Stabenfeldt, G. H., 1988, Use of pulsatile intravenous administration of gonadotropin-releasing hormone to induce fertile estrus in bitches, Am. J. Vet. Res. 49: 1993–1996.

    PubMed  CAS  Google Scholar 

  • Christensen, G. C., 1979, The urogenital system, in: Miller’s Anatomy of the Dog, ed. 2 ( H. E. Evans and G. C. Christensen, eds.), W. B. Saunders, Philadelphia, pp. 544–601.

    Google Scholar 

  • Concannon, P. W, 1986, Canine physiology of reproduction, in: Small Animal Reproduction and Infertility: A Clinical Approach to Diagnosis and Treatment ( T. J. Burke, ed.), Lea and Febiger, Philadelphia, pp. 23–77.

    Google Scholar 

  • Doak, R. L., Hall, A., and Dale, H. E., 1967, Longevity of spermatozoa in the reproductive tract of the bitch, J. Reprod. Fertil. 13: 51–58.

    Article  CAS  Google Scholar 

  • El Etreby, M. F., Graft, K.-J., Beier, S., Elger, W., Gunzel, P, and Neuman, F, 1979, Suitability of the beagle dog as a test model for the tumorigenic potential of contraceptive steroids, short review, Contraception 20: 237–255.

    Article  PubMed  Google Scholar 

  • Evans, E. I., 1933, The transport of spermatozoa in the dog, Am. J. Physiol. 105: 287–293.

    Google Scholar 

  • Evans, H. E., 1974, Prenatal development of the dog, in: Gaines Veterinary Symposium at Cornell University, pp. 18–28.

    Google Scholar 

  • Evans, H. E., 1979, Reproduction and prenatal development, in: Miller’s Anatomy of the Dog, ed. 2 ( H. E. Evans and G. C. Christensen, eds.), W. B. Saunders, Philadelphia, pp. 13–77.

    Google Scholar 

  • Evans, H. M., and Cole, H. H., 1931, An introduction to the study of the oestrous cycle in the dog, Mem. Univ. Calif. 9: 65–119.

    Google Scholar 

  • Fielden, E. D., 1971, Artificial insemination in the dog, N. Z. Vet. J. 19: 178–184.

    Article  PubMed  CAS  Google Scholar 

  • Foote, R. H., Swierstra, E. E., and Hunt, W. L., 1972, Spermatogenesis in the dog, Anat. Rec. 173: 341–352.

    Article  PubMed  CAS  Google Scholar 

  • Frank, D. W, Kirton, K. T., Murchison, T. E., Quinlan, W. J., Coleman, M. E., Gilbertson, T. J., Feenstra, E. S., and Kimball, F. A., 1979, Mammary tumors and serum hormones in the bitch treated with medroxyprogesterone acetate or progesterone for four years, Fertil. Steril. 31: 340–346.

    PubMed  CAS  Google Scholar 

  • Froman, D. P, Amann, R. P, Riek, P M., and Olar, T. T, 1984, Acrosin activity of canine spermatozoa as an index of cellular damage, J. Reprod. Fertil. 70: 301–308.

    Article  PubMed  CAS  Google Scholar 

  • Garner, D. L., Finkel, D., Johnson, L. A., and Pace, M. M., 1986, Assessment of spermatozoa) function using dual fluorescent staining and flow cytometric analyses, Biol. Reprod. 34: 127–138.

    Article  PubMed  CAS  Google Scholar 

  • Ghosal, S. K., LaMarche, P H., Bhanja, P, Joardar, S., Sengupta, A., and Midya, T., 1983, Duration of meiosis and spermiogenesis in the dog, Can. J. Genet. Cytol. 25: 678–681.

    PubMed  CAS  Google Scholar 

  • Grandage, J., 1972, The erect dog penis: A paradox of flexible rigidity, Vet. Rec. 91: 141–147.

    Article  PubMed  CAS  Google Scholar 

  • Hamner, C. E., Jennings, L. L., and Sojka, N. J., 1970, Cat (Fells catus L.) spermatozoa require capacitation, J. Reprod. Fertil. 23: 477–480.

    Article  PubMed  CAS  Google Scholar 

  • Hancock, J. L., and Rowlands, I. W., 1949, The physiology of reproduction in the dog, Vet. Rec. 47: 771–776.

    Google Scholar 

  • Harrop, A. E., 1960, Reproduction in the Dog. Bailliere, Tindal and Cox, London.

    Google Scholar 

  • Holst, P. A., and Phemister, R. D., 1971, The prenatal development of the dog: Preimplantation events, Biol. Reprod. 5: 194–206.

    PubMed  CAS  Google Scholar 

  • Holst, P. A., and Phemister, R. D., 1974, Onset of diestrus in the beagle bitch: Definition and significance, Am. J. Vet. Res. 35: 401–406.

    PubMed  CAS  Google Scholar 

  • Huggins, C., 1945, The physiology of the prostate gland, Physiol Rev. 25: 281–295.

    CAS  Google Scholar 

  • Huggins, C., 1947, The prostatic secretion, Harvey Lect. 42: 148–193.

    CAS  Google Scholar 

  • Huggins, C., Masina, M. H., Eichelberger, L., and Wharton, J. D., 1939, Quantitative studies of prostatic secretion. I. Characteristics of the normal secretion; the influence of thyroid, suprarenal, and testis extirpation and androgen substitution on the prostatic output, J. Exp. Med. 70: 543–556.

    Article  PubMed  CAS  Google Scholar 

  • Isaacs, W. B., and Coffey, D. S., 1984, The predominant protein of canine seminal plasma is an enzyme, J. Biol. Chem. 259: 11520–11526.

    PubMed  CAS  Google Scholar 

  • Kennelly, J. J., and Johns, B.E., 1976, The estrous cycle of coyotes, J. Wildl. Manag. 40: 272–277.

    Article  Google Scholar 

  • Kinney, G. M., Pennycook, J. W, Schriver, M. D., Templeton, J. W, and Kraemer, D. C., 1979, Surgical collection and transfer of canine embryos, Biol. Reprod. 20 (Suppl. 2): 96A.

    Google Scholar 

  • Kuroda, H., and Hiroe, K., 1972, Studies on the metabolism of dog spermatozoa. I. Seasonal variation on the semen quality and of the aerobic metabolism of spermatozoa, Jpn. J. Anim. Reprod. 17: 89–98.

    Article  Google Scholar 

  • Mahi, C. A., and Yanagimachi, R., 1976, Maturation and sperm penetration of canine ovarian oocytes in vitro, J. Exp. Zool. 196: 189–196.

    Article  CAS  Google Scholar 

  • Mahi, C. A., and Yanagimachi, R., 1978, Capacitation, acrosome reaction, and egg penetration by canine spermatozoa in a simple defined medium, Gamete Res. 1: 101–109.

    Article  Google Scholar 

  • Mahi-Brown, C. A., 1986, Prospects for control of fertility in the female dog by active immunization with porcine zona pellucida proteins, in: Immunological Approaches to Contraception and Promotion of Fertility ( G. P Talwar, ed.), Plenum Press, New York, pp. 301–309.

    Chapter  Google Scholar 

  • Mead, R. A., 1981, Delayed implantation in mustelids with special emphasis on the spotted skunk, J. Reprod. Fertil. Suppl. 29: 11–24.

    PubMed  CAS  Google Scholar 

  • Meizel, S., 1985, Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface, Am. J. Anat. 174: 285–302.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, O. P, and Enders, R. K., 1943, Ovulation, maturation and fertilization in the fox, Anat. Rec. 85: 69–83.

    Article  Google Scholar 

  • Phemister, R. D., Holst, P A., Spano, J. S., and Hopwood, M. L., 1973, Time of ovulation in the beagle bitch, Biol. Reprod. 8: 74–82.

    PubMed  CAS  Google Scholar 

  • Province, C. A., Amann, R. P, Pickett, B. W., and Squires, E. L., 1984, Extenders for preservation of canine and equine spermatozoa at 5°C, Theriogenology 22: 409–415.

    Article  PubMed  CAS  Google Scholar 

  • Seager, S. W. J., 1969, Successful pregnancies utilizing frozen dog semen, A. I. Digest 17: 1–2.

    Google Scholar 

  • Seager, S. W. J., and Fletcher, W. S., 1972, Collection, storage, and insemination of canine semen, Lab. Anim. Sci. 22: 177–182.

    PubMed  CAS  Google Scholar 

  • Seager, S. W, J., Platz, C. C., and Fletcher, W. S., 1975, Conception rates and related data using frozen dog semen, J. Reprod. Fertil. 45: 189–192.

    CAS  Google Scholar 

  • Seal, U. S., Plotka, E. D., Packard, J. M., and Mech, L.D., 1979, Endocrine correlates of reproduction in the wolf. I. Serum progesterone, estradiol and LH during the estrous cycle, Biol. Reprod. 21: 1057–1066.

    Article  PubMed  CAS  Google Scholar 

  • Setchell, B. P, and Brooks, D. E., 1988, Anatomy, vasculature, innervation, and fluids of the male reproductive tract, in: The Physiology of Reproduction, Vol. 1(E. Knobil and J. D. Neill, eds.), Raven Press, New York, pp. 753–836.

    Google Scholar 

  • Shille, V. M., and Stabenfeldt, G. H., 1980, Current concepts in reproduction of the dog and cat, in: Advances in Veterinary Science and Comparative Medicine, Vol. 24 ( C. A. Brandly and C. E. Cornelius, eds.), Academic Press, New York, pp. 211–243.

    Google Scholar 

  • Shille, V. M., Thatcher, M.-J., Buhi, W. C., Alvarez, I. M., and Lannon, A. P, 1988, Protein synthesis by endometrium and embryo during early pregnancy in the bitch, Biol. Reprod. 38 (Suppl. 1): 132.

    Google Scholar 

  • Smith, F O., and Graham, E. F., 1984, Cryopreservation of canine semen: Technique and performance, in: Proceedings of the 10th International Congress of Animal Reproduction and Artificial Insemination Vol. 2, Urbana-Champaign, p. 216.

    Google Scholar 

  • Sokolowski, J. H., 1971, The effects of ovariectomy on pregnancy maintenance in the bitch, Lab. Anim. Sci. 21: 696–699.

    PubMed  CAS  Google Scholar 

  • Sokolowski, J. N., Zimbelman, R. G., and Goyings, L.S., 1973, Canine reproduction: Reproductive organs and related structures of the nonparous, parous, and postpartum bitch, Am. J. Vet. Res. 34: 1001–1013.

    PubMed  CAS  Google Scholar 

  • Takeisi, M., Mikami, T., Kodama, Y., Tsunekane, T., and Iwaki, T., 1976, Studies on the reproduction in the dog. VII. Artificial insemination using the frozen semen, Jpn. J. Anim. Reprod. 22: 28–33.

    Article  Google Scholar 

  • Takeishi, M., Akai, R., Tsunekane, T., Iwaki, T., and Nakanowatari, K., 1980, Studies on the reproduction in dogs—A trial of ova transplantation in dogs, Jpn. J. Anim. Reprod. 26: 151–153.

    Article  Google Scholar 

  • Tash, J. S., Hidaka, H., and Means, A. R., 1986, Axokinin phosphorylation by cAMP-dependent protein kinase is sufficient for activation of sperm flagellar motility, J. Cell Biol. 103: 649–655.

    Article  PubMed  CAS  Google Scholar 

  • Tash, J. S., Krinks, M., Patel, J., Means, R. L., Klee, C. B., and Means, A. R., 1988, Identification, characterization, and functional correlation of calmodulin-dependent protein phosphatase in sperm, J. Cell. Biol. 106: 1625–1633.

    Article  PubMed  CAS  Google Scholar 

  • Tesoriero, J. V, 1981, Early ultrastructural changes of developing oocytes in the dog, J. Morphol. 168: 171–179.

    Article  PubMed  CAS  Google Scholar 

  • Tesoriero, J. V, 1982, A morphologic, cytochemical, and chromatographic analysis of lipid yolk formation in the oocytes of the dog, Gamete Res. 6: 267–279.

    Article  CAS  Google Scholar 

  • Tsutsui, T., 1975, Studies on the reproduction in the dog. V. On cleavage and transport of fertilized ova in the oviduct, Jpn. J. Anim. Reprod. 21: 70–75.

    Article  Google Scholar 

  • Tsutsui, T., and Shimizu, T., 1975, Studies on the reproduction in the dog. IV. On the fertile period of ovum after ovulation, Jpn. J. Anim. Reprod. 21: 65–69.

    Article  Google Scholar 

  • Valtonen, M. H., Rajakoski, E. J.,and Makela, J. I., 1977, Reproductive features in the female racoon dog (Nyctereutes procyonoides), J. Reprod. Fertil. 51: 517–518.

    CAS  Google Scholar 

  • Van der Stricht, O., 1923, Etude comparée des ovules des mammifères aux différentes périodes de l’ovogenèse, d’après les travaux du Laboratoire d’Histologie et d’Embryologie de l’Université de Gand, Arch. Biol., Paris 33: 229–300.

    Google Scholar 

  • Wales, R. G., and White, I. G., 1958, The interaction of pH, tonicity and electrolyte concentration on the motility of dog spermatozoa, J. Physiol. (Lond.) 141: 273–280.

    CAS  Google Scholar 

  • Wassarman, P. M., 1988, The mammalian ovum, in: The Physiology of Reproduction, Vol. 1 ( E. Knobil and J. D. Neill, eds.), Raven Press, New York, pp. 69–102.

    Google Scholar 

  • Woodall, P. E, and Johnstone, I. P, 1988, Dimensions and allometry of testes, epididymides and spermatozoa in the domestic dog (Canis familiaris), J. Reprod. Fertil. 82: 603–609.

    Article  PubMed  CAS  Google Scholar 

  • Yanagimachi, R., 1988a, Sperm–egg fusion, in: Current Topics in Membranes and Transport, Vol. 32, Membrane Fusion in Fertilization, Cellular Transport and Viral Infection ( N. Duzgunes and F. Bronner, eds.), Academic Press, New York, pp. 3–43.

    Chapter  Google Scholar 

  • Yanagimachi, R., 1988b, Mammalian fertilization, in: The Physiology of Reproduction, Vol. 1 ( E. Knobil and J. D. Neill, eds.), Raven Press, New York, pp. 135–185.

    Google Scholar 

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Authors and Affiliations

  1. California Primate Research Center, University of California, Davis, California, 95616, USA

    Cherrie A. Mahi-Brown

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  1. Cherrie A. Mahi-Brown
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Editors and Affiliations

  1. Department of Cell Biology, Baylor College of Medicine, 77030, Houston, Texas, USA

    Bonnie S. Dunbar

  2. Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, 27599, Chapel Hill, North Carolina, USA

    Michael G. O’Rand

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Mahi-Brown, C.A. (1991). Fertilization in Dogs. In: Dunbar, B.S., O’Rand, M.G. (eds) A Comparative Overview of Mammalian Fertilization. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-8982-9_15

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  • DOI: https://doi.org/10.1007/978-1-4757-8982-9_15

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