Abstract
ABH and Lewis antigens are carbohydrates present on gut epithelial cells. These antigens provide diversity within the human population. Their biosynthesis largely is controlled by the enzyme products of alleles at the ABO, FUT2 and FUT3 loci. We have shown that Norwalk virus (NV) uses structures based on H type 1 as its primary receptor. Norwalk virus is the prototype of human caliciviruses, which collectively are responsible for the majority of gastroenteritis outbreaks in people of all ages. Individuals with two mutated FUT2 alleles, and therefore devoid of H type 1 epitopes on their gut epithelial cells, are called nonsecretors and are resistant to infection by NV. This genetically controlled mechanism of resistance to NV also might be important in the protection of infants by human milk, yet in an inverse manner since, unlike milk from secretors, the milk from nonsecretor mothers does not inhibit attachment of recombinant NV particles to their primary receptor. This suggests that breastfeeding by a secretor mother should protect a secretor child from NV infection, whereas breastfeeding by a nonsecretor mother should not.
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References
Bengston P, Larson C, Lundblad A, Larson G, Pahlsson P. Identification of a missense mutation (G329A; Arg(110)>GLN) in the human FUT7 gene. J Biol Chem 2001:276;31575–31582.
Blancher A, Socha WW. ABO, Hh and Lewis blood groups in humans and nonhuman primates. In: Blancher A, Klein J, Socha WW, editors. Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Berlin: Springer-Verlag, 1997; pp 30–92.
Brown KE, Anderson SM, Young NS. Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science 1993;262:114–116.
Cailleau-Thomas A, Coullin P, Candelier JJ, Balanzino L, Mennesson B, Oriol R, Mollicone R. FUT4 and FUT9 genes are expressed early in human embryogenesis. Glycobiology 2000;10:789–802.
Dai D, Nanthakumar NN, Newburg DS, Walker AM. Role of oligosaccharides and glycoconjugates in intestinal host defense. J Pediatr Gastroenterol Nutr 2000;30:S23–S33.
Glass RI, Bresee JS, Jiang B, Gentsch JR, Ando T, Fankhauser R, Noel J, Parashar UD, Rosen B, Monroe SS. Gastroenteritis viruses: an overview. Novartis Foundation Symposium 2001;238:5–19.
Griffitts JS, Whitacre JL, Stevens DE, Aroian RV. Bt toxin resistance from loss of a putative carbohydrate-modifying enzyme. Science 2001:293 ;860–864.
Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta 1999:1473;247–266.
Harrington PR, Lindensmith L, Yount B, Moe CL, Baric RS. Binding of Norwalk virus-like particles to ABH histo-blood group antigens is blocked by antisera from infected human volunteers or experimentally vaccinated mice. J Virol 2002:76;12325–12343.
Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis 2002:185;1335–1337.
Hutson AM, Atmar RL, Marcus DM, Estes MK. Norwalk virus-like particles hemagglutination by binding to H histo-blood group antigens. J Virol 2003:77;405–415.
Jiang X, Wang M, Graham DY, Estes MK. Expresion, self-assembly, and antigenicity of the Norwalk virus capsid protein. J Virol 1992:66;6527–6532.
Kapikian AZ. The discovery of the 27-nm Norwalk virus: an historic perspective. J Infect Dis 2000:181;S295–S296.
Lindesmith L, Moe C, Marionneau S, Ruvoen N, Jiang X, Lindblad L, Stewart P, LePendu J, Baric R. Human susceptibility and resistance to Norwalk virus infection. Nat Med 2003;9:548–553.
Marionneau S, Cailleau-Thomas A, Rocher J, Le Moullac-Vaidye B, Ruvoën-Clouet N, Clément M, Le Pendu J. ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world. Biochimie 2001:83;565–573.
Marionneau S, Ruvöen-Clouet N, Le Moullac-Vaidye B, Clement M, Cailleau-Thomas A, Ruiz-Palacios G, Huang PW, Jiang X, Le Pendu J. Norwalk virus binds to H types 1/3 histo-blood group antigens on gastro-duodenal epithelial cells of “secretor” individuals. Gastroenterology 2002:122; 1967–1977.
Mollicone R, Reguigne I, Fletcher A, Aziz A, Rustam M, Weston BW, Kelly RJ, Lowe JB, Oriol R. Molecular basis for plasma alpha(l,3)-fucosyltransferase gene deficiency (FUT6). J Biol Chem 1994a:269; 12662–12671.
Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, Aziz A, Cameron HS, Weston BW, Lowe JB. Molecular basis for Lewis alpha(l,3/l,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees. J Biol Chem 1994b:269;20987–20994.
Moulds JM, Nowicki S, Moulds JJ, Nowicki BJ. Human blood groups: incidental receptors for viruses and bacteria. Transfusion 1996:36;362–374.
Ruvoën-Clouet N, Ganière JP, André-Fontaine G, Blanchard D, Le Pendu J. Binding of rabbit hemorrhagic disease virus to antigens of the ABH histo-blood group family. J Virol 2000:74;11950–11954.
Thiel HJ, König M. Caliciviruses: an overview. Vet Microbiol 1999:69;55–62.
Watkins WM. A half century of blood-group antigen research. Some personal recollections. Trends Glycosci Glycotechnol 1999:11;391–411.
Zopf D, Roth S. Oligosaccharide anti-infective agents. Lancet 1996:347;1017–1021.
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Le Pendu, J. (2004). Histo-Blood Group Antigen and Human Milk Oligosaccharides. In: Pickering, L.K., Morrow, A.L., Ruiz-Palacios, G.M., Schanler, R.J. (eds) Protecting Infants through Human Milk. Advances in Experimental Medicine and Biology, vol 554. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-4242-8_13
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DOI: https://doi.org/10.1007/978-1-4757-4242-8_13
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