Abstract
The plasma protein that transports vitamin D and its metabolites [vitamin D binding protein (DBP)] was first recognized as a postalbumin component of human sera during electrophoretic analyses (1). Subsequently, the identity of this group-specific component (Gc-globulin) and plasma DBP was discovered (2) and confirmed (3). The protein is synthesized in the liver and displays features homologous with albumin and α-fetoprotein (4). Neither of the latter proteins binds vitamin D sterols with high affinity, however. DBP is 122 amino acids shorter than albumin and α-fetoprotein, and the genes of all three of these proteins map to human chromosome 4g11–22 (4).
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Haddad, J.G. (1999). The Vitamin D Binding Protein and Its Clinical Significance. In: Holick, M.F. (eds) Vitamin D. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4757-2861-3_6
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DOI: https://doi.org/10.1007/978-1-4757-2861-3_6
Publisher Name: Humana Press, Totowa, NJ
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