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Animal Models for Tumors of the Female Genital Tract

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Blaustein’s Pathology of the Female Genital Tract
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Abstract

The ultimate objective of animal studies of cancer is to achieve a better understanding of factors responsible for human disease in the hope that it may be eliminated or controlled. Information about spontaneously occurring tumors comes largely from veterinary records of tumors in domesticated animals, but also from wild animals and animals in zoos and laboratories. Study of the commonly occurring tumors in animals can provide epidemiologic and other clues to their etiology, as well as material for biologic and therapeutic investigation.

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References

  1. Alkermans JPWM, Van Beusekom WJ (1984) Tumors and tumor-like lesions in the genitalia of sows. Vet Q 6: 90

    Google Scholar 

  2. Allen E, Gardner WU (1941) Cancer of the cervix of the uterus in hybrid mice following long-continued administration of estrogen. Cancer Res 1: 359

    CAS  Google Scholar 

  3. Alvizouri M, De Pita VR (1964) Experimental carcinoma of the cervix. Hormonal influences. Am J Obstet Gynecol 89: 940

    Google Scholar 

  4. Anderson LJ, Sandison AT, Jarrett WFH (1969) A British abbatoir survey of tumors in cattle, sheep and pigs. Vet Rec 84: 547

    PubMed  CAS  Google Scholar 

  5. Andervont HB, Dunn TB (1962) Occurrence of tumors in wild house mice. J Natl Cancer Inst 28: 1153

    PubMed  CAS  Google Scholar 

  6. Baba N, Haam E von (1967) Experimental carcinoma of the endometrium. Prog Exp Tumor Res Basel 9: 192

    CAS  Google Scholar 

  7. Baba N, Haam E von (1971) Squamous cell carcinoma of the rat endometrium produced by insertion of strings coated with paraffin and polymer. J Natl Cancer Inst 47: 675

    PubMed  CAS  Google Scholar 

  8. Baba N, Haam E von (1972) Spontaneous carcinoma in aged rabbits. Am J Pathol 68: 653

    PubMed  CAS  Google Scholar 

  9. Bacon RR (1952) Tumors of the epididymus and of the uterus in hamsters treated with diethylstilbestrol and testosterone propionate. Cancer Res 12: 246

    Google Scholar 

  10. Barbieri G, Olivi M, Sacco O (1958) Lesioni microscopiche nel’ uteri di topi ( BALB/Cf, C3H/CB/Se substrain) trattati con benzoato di estradiolo. Lay Inst Anat Istol Patol Perugia 18: 165

    Google Scholar 

  11. Beamer WG (1980) Endocrine aspects of ovarian tumours. In: Biology of Ovarian Neoplasia, UICC Technical Report Series. Murphy ED, Beamer WG (eds). Geneva, Union Internationale Contre le Cancer, Vol 50, p 82

    Google Scholar 

  12. Benedetti EL, van Nie R (1962) On the histology and fine structure of uterine tumours induced by testosterone in mice. Acta Un Contr Cancr 18: 197

    CAS  Google Scholar 

  13. Biancifiori C, Bonser GM, Caschera F (1961) Ovarian and mammary tumours in intact C3Hb virgin mice following a limited dose of four carcinogenic chemicals. Br J Cancer 15: 270

    PubMed  CAS  Google Scholar 

  14. Bielschowsky F (1944) Distant tumours produced by 2aminofluorene and 2-acetyl aminofluorene. Br J Exp Pathol 25: 1

    CAS  Google Scholar 

  15. Bielschowsky M, D’Ath EF (1973) Spontaneous granulosa cell tumours of mice of strain NZC-Bi, NZO-Bi, NZYBi and NZB-Bi. Pathology 5: 303

    Google Scholar 

  16. Bielschowsky F, Hall WH (1951) Carcinogenesis in parabiotic rats joined to gonadectomised litter mates and the reaction of their pituitaries to endogenous estrogens. Br J Cancer 5: 331

    PubMed  CAS  Google Scholar 

  17. Biskind GR, Biskind MS (1949) Experimental ovarian tumors in rats. Am J Clin Pathol 19: 501

    PubMed  CAS  Google Scholar 

  18. Biskind GR, Bernstein DE, Gospe SM (1953) The effect of exogenous gonadotrophins on the development of ovarian tumors in rats. Cancer Res 13: 216

    PubMed  CAS  Google Scholar 

  19. Biskind GR, Kordan B, Biskind MS (1950) Ovary transplanted to spleen in rats. The effect of unilateral castration, pregnancy and subsequent castration. Cancer Res 10: 309

    Google Scholar 

  20. Bonser GM, Jull JW (1974) Tumors of the ovary. Personal communication

    Google Scholar 

  21. Bonser GM, Robson JM (1950) The induction of tumours following the direct implantation of 20-methylcholanthrene in the uterus of mice. Br J Cancer 4: 196

    PubMed  CAS  Google Scholar 

  22. Boyland E, Charles RT, Cowing NFC (1961) The induction of tumours in mice by intravaginal application of chemical compounds. Br J Cancer 15: 252

    PubMed  CAS  Google Scholar 

  23. Brambell FWR, Fielding U, Parkes AS (1927) Changes in the ovary of the mouse following exposure to x-rays. Part III. Irradiation of the non-parous adult. Proc R Soc Lond [Biol] 101: 316

    Google Scholar 

  24. Brandly PJ, Migaki G (1963) Types of tumors found by federal meat inspectors in an eight-year survey. Ann NY Acad Sci 108: 872

    PubMed  CAS  Google Scholar 

  25. Brownstein DG, Brooks AL (1980) Spontaneous endomyo-metrial neoplasms in aging Chinese hamsters. J Natl Cancer Inst 64: 1209

    PubMed  CAS  Google Scholar 

  26. Bruzzone S, Lipschutz A (1954) Endometrial adenocarcinoma and extragenital tumours in guinea-pigs with “ovarian fragmentation.” Br J Cancer 8: 613

    PubMed  CAS  Google Scholar 

  27. Bullock FD, Curtis MR (1930) Spontaneous tumors of the rat. J Cancer Res 14: 1

    Google Scholar 

  28. Burrows H (1940) Spontaneous uterine and mammary tumours in the rabbit. J Pathol Bacteriol 51: 385

    Google Scholar 

  29. Butler WH, Barnes JM (1968) Carcinogenic action of groundnut meal containing aflatoxin in rats. Food Cosmet Toxicol 6: 135

    PubMed  CAS  Google Scholar 

  30. Campbell JG (1951) Some unusual gonadal tumours of the fowl. Br J Cancer 5: 69

    PubMed  CAS  Google Scholar 

  31. Carter RL (1968) Pathology of ovarian neoplasms in rats and mice. Eur J Cancer 3: 537

    PubMed  CAS  Google Scholar 

  32. Castro HF, Fechner RE, Spjut HJ (1968) Induced mesenchymal tumors of the rat genital tract. Arch Pathol 86: 475

    PubMed  CAS  Google Scholar 

  33. Charkviani LI (1961) [Experimental cancer of the uterus produced in rats by 9,10-dimethyl-1,2-benzanthracene]. Vopr Onkol 7: 52

    Google Scholar 

  34. Chesterman FC, Pomerance A (1965) Spontaneous neoplasms in ferrets and polecats. J Pathol Bacteriol 89: 529

    PubMed  CAS  Google Scholar 

  35. Chouroulinkov I, Guillon JC, Guerin M (1969) Endometrial sarcomas in mice: A survey of 130 cases. J Natl Cancer Inst 42: 593

    PubMed  CAS  Google Scholar 

  36. Christov K, Raichev R (1973) Proliferative and neoplastic changes in the ovaries of hamsters treated with 131-iodine and methylthiouracil. Neoplasma 20: 511

    PubMed  CAS  Google Scholar 

  37. Clapp NK (1978) Ovarian tumor types and their incidence in intact mice following whole-body exposure to ionising radiation. Radiat Res 74: 405

    PubMed  CAS  Google Scholar 

  38. Cohen D (1978) The transmissible venereal tumor of the dog. A naturally occurring allograft? A review. Isr J Med Sci 14: 14

    PubMed  CAS  Google Scholar 

  39. Cohen D (1985) Canine transmissable venereal tumor: A unique result of tumor progression. Adv Canc Res 43: 75

    CAS  Google Scholar 

  40. Cordes DO (1969) Equine granulosa tumours. Vet Rec 85: 186

    PubMed  CAS  Google Scholar 

  41. Corfman PA, Richart RM (1967) Induction in rats of uterine epidermoid carcinomas by plastic and stainless steel intrauterine devices. Am J Obstet Gynecol 98: 987

    PubMed  CAS  Google Scholar 

  42. Cotchin E (1964) Spontaneous uterine tumours in animals. Br J Cancer 18: 209

    PubMed  CAS  Google Scholar 

  43. Cotchin E (1977) Spontaneous tumors of the uterus and ovaries in animals. In: Animal Tumors of the Female Reproductive Tract: Spontaneous and Experimental. Cotchin E, Marchant J. New York, Springer-Verlag

    Google Scholar 

  44. Damjanov I (1980) Yolk sac carcinoma (endodermal sinus tumor). Animal model: Parietovisceral yolk sac carcinoma in the rat. Am J Pathol 98: 569

    PubMed  CAS  Google Scholar 

  45. Damjanov I, Sell S (1977) Yolk-sac carcinoma grown from rat egg cylinder. J Natl Cancer Inst 58: 1523

    PubMed  CAS  Google Scholar 

  46. Damjanov I, Solter D (1973) Yolk-sac carcinoma grown from mouse egg cylinder. Arch Pathol. 95: 182

    PubMed  CAS  Google Scholar 

  47. Damjanov I, Solter D (1974) Experimental teratoma. Curr Top Pathol 59: 69

    PubMed  CAS  Google Scholar 

  48. Damjanov I, Solter D (1976) Animal models of human disease: Embryo-derived teratomas and teratocarcinomas in mice. Am J Pathol 83: 241

    Google Scholar 

  49. Davies J, Kusama H (1962) Developmental aspects of the human cervix. Ann NY Acad Sci 97: 534

    Google Scholar 

  50. Davy M, Mossige J, Johannessen JV (1977) Heterologous growth of human ovarian cancer. A new in vivo testing system. Gynecol Scand 56: 55

    Google Scholar 

  51. Dawson PJ, Brooks RE, Fieldsteel AH (1974) Unusual occurrence of endometrial sarcomas in hybrid mice. J Natl Cancer Inst 52: 207

    PubMed  CAS  Google Scholar 

  52. Deringer MK (1959) Occurrence of tumors, particularly mammary tumors, in agent-free strain C3HeB mice. J Natl Cancer Inst 22: 995

    PubMed  CAS  Google Scholar 

  53. Dickie MM (1954) The use of F1 hybrid and backcross generations to reveal new and/or uncommon tumor types. J Natl Cancer Inst 15: 791

    PubMed  CAS  Google Scholar 

  54. Drill UA (1980) Relationship of estrogens and oral contraceptives to endometrial cancer in animals and women. J Reprod Med 24: 7724

    Google Scholar 

  55. Druckrey H, Preussman R, Ivankovic S, Schmahl D (1967) Organotrope carcinogene Wirkungen bei 65 verscheidenen N-Nitroso- Verbindungen an BD-Ratten. Z Krebsforsch 69: 103

    PubMed  CAS  Google Scholar 

  56. Dunn TB (1954) The importance of differences in morphology in inbred strains. J Natl Cancer Inst 15: 573

    PubMed  CAS  Google Scholar 

  57. Dunn TB (1969) Cancer of the uterine cervix in mice fed a liquid diet containing anti-fertility drug. J Natl Cancer Inst 46: 671

    Google Scholar 

  58. Dunn TB, Green AW (1963) Cysts of the epididymus, cancer of the cervix, granular myoblastoma, and other lesions after estrogen injection in newborn mice. J Natl Cancer Inst 31: 425

    PubMed  CAS  Google Scholar 

  59. El-Banna AA, Hafez ESE (1971) The uterine cervix in mammals. Am J Obstet Gynecol 112: 145

    Google Scholar 

  60. Eppig JJ, Kozac LP, Eicher EM, Stevens LC (1977) Ovarian teratomas in mice are derived from oocytes that have completed the first meiotic division. Nature 269: 517

    PubMed  CAS  Google Scholar 

  61. Fawcett DW (1950) Bilateral ovarian teratomas in a mouse. Cancer Res 10: 705

    PubMed  CAS  Google Scholar 

  62. Fekete E, Ferringo MA (1952) Studies on a transplantable teratoma of the mouse. Cancer Res 12: 438

    PubMed  CAS  Google Scholar 

  63. Fels E (1954) Effet de la ligature tubaire sur la fonction ovarienne chez le rat. CR Soc Biol 148: 1666

    CAS  Google Scholar 

  64. Fels E (1956) Aspectos morfologicos y functionales de los tumores experimentales del ovario. Rev Arg Endocrinol Metab 2: 1

    Google Scholar 

  65. Fishman M, Shear MJ, Friedman HF, Stewart HL (19411942) Studies in carcinogenesis. XVII. Local effect of repeated application of 3,4-benzpyrene and of human smegma to the vagina and the cervix of mice. J Natl Cancer Inst 2: 361

    Google Scholar 

  66. Flux JEC (1965) Incidence of ovarian tumors in hares in New Zealand. J Wildl Mgmnt 29: 622

    Google Scholar 

  67. Fukunishi R, Wang H, Yoshida A, Yoshida H, Hirota N (1975) Induction of ovarian tumor in rats with N-butylnitrosourea. Gann 66: 323

    PubMed  CAS  Google Scholar 

  68. Furth J (1946) Transplantability of induced granulosa cell tumors and of luteoma in mice. Secondary effects of these growths. Proc Soc Exp Biol Med 61: 212

    PubMed  CAS  Google Scholar 

  69. Furth J, Boon MC (1947) Induction of ovarian tumors in mice by x-rays. Cancer Res 7: 241

    PubMed  CAS  Google Scholar 

  70. Furth J, Butterworth JS (1936) Neoplastic diseases occurring among mice subjected to general irradiation with x-rays. II. Ovarian tumors and associated lesions. Am J Cancer 28: 66

    Google Scholar 

  71. Furth J, Furth OB (1936) Neoplastic diseases produced in mice by general irradiation with x-rays. Am J Cancer 28: 54

    Google Scholar 

  72. Furth J, Sobel H (1947) Transplantable luteoma in mice and associated secondary changes. Cancer Res 7: 246

    PubMed  CAS  Google Scholar 

  73. Furth J, Sobel H (1947) Neoplastic transformations of granulosa cells in grafts of normal ovaries into spleens of gonadectomised mice. J Natl Cancer Inst 8: 7

    PubMed  CAS  Google Scholar 

  74. Gardner WU (1947) Studies on steroid hormones in experimental carcinogenesis. Rec Prog Horm Res 1: 127

    Google Scholar 

  75. Gardner WU (1959) Experimental induction of uterine, cervical and vaginal cancer in mice. Cancer Res 19: 170

    PubMed  CAS  Google Scholar 

  76. Gardner WU (1961) Tumorigenesis in transplanted irradiated and nonirradiated ovaries. J Natl Cancer Inst 26: 829

    PubMed  CAS  Google Scholar 

  77. Gardner WU, Allen E (1939) Malignant and non-malignant uterine and vaginal lesions in mice receiving estrogens and androgens simultaneously. Yale J Biol Med 12: 213

    PubMed  CAS  Google Scholar 

  78. Gardner WU, Ferrigno M (1956) Unusual neoplastic lesions in the uterine horns of estrogen-treated mice. J Natl Cancer Inst 17: 601

    PubMed  Google Scholar 

  79. Gardner WU, Pan SC (1948) Malignant tumors of the uterus and vagina in untreated mice of the PM stock. Cancer Res 8: 241

    PubMed  CAS  Google Scholar 

  80. Gardner WU, Allen E, Strong LC (1936) Atypical uterine and vaginal changes in mice receiving large doses of estrogenic hormone (Abstr). Anat Rec 64: 17 [Suppl 3]

    Google Scholar 

  81. Geary CP (1984) Carcinogen-induced granulosa cell tumors in NZC/BL mice. Pathology 16: 131

    PubMed  CAS  Google Scholar 

  82. Gellatly JBM (1967) Normal and pathological anatomy and histology of the genital tract of rats and mice. In: Pathology of Laboratory Rats and Mice. Cotchin E, Roe FCJ (eds). Oxford and Edinburgh, Blackwell Scientific Publications, p 498

    Google Scholar 

  83. Gilloteaux J, Paul RJ, Steggles AW (1982) Upper genital tract abnormalities in the Syrian hamster as a result of in utero exposure to diethylstilbestrol. I. Uterine cystadenomatous papilloma and hypoplasia. Virchows Arch 398: 163

    Google Scholar 

  84. Giovanella BC, Stehlin JS (1974) Influence of the host’s sex on the growth of human tumors heterotransplanted in “nude” thymusless mice ( Abstr ). Am Assoc Cancer Res 15: 92

    Google Scholar 

  85. Glucksman A (1971) Some effects of steroid hormones on carcinogenesis in rats: Effects of oestrogens on the induction of tumours in the cervico-vaginal tract and in the salivary glands. In: Some Implications of Steroid Hormones in Cancer. Williams DC, Briggs MC (eds). London, Heinemann, p 70

    Google Scholar 

  86. Glucksman A, Cherry CP (1962) The effect of castration and of additional hormone treatments on the induction of cervical and vulval tumours in mice. Br J Cancer 16: 634

    Google Scholar 

  87. Glucksman A, Cherry CP (1970) The effect of increased numbers of carcinogenic treatments on the induction of cervico-vaginal and vulval tumors in intact and castrate rats. Br J Cancer 24: 333

    Google Scholar 

  88. Goodchild WM, Cooper DM (1968) Oviduct adenocarcinoma in laying hens. Vet Rec 82: 389

    Google Scholar 

  89. Gorski RA, Wagner JW (1965) Gonadal activity and sexual differentiation of the hypothalamus. Endocrinology 76: 226

    PubMed  CAS  Google Scholar 

  90. Graham CE (1966) Cyclic changes in the squamocolumnar junction of the mouse cervix uteri. Anat Rec 155: 251

    PubMed  CAS  Google Scholar 

  91. Graham CE (1971) Histogenesis of methylcholanthreneinduced murine cervical cancer. Oncology 25: 269

    PubMed  CAS  Google Scholar 

  92. Graham CE, McKlure HM (1977) Ovarian tumors and related lesions in aged chimpanzees. Vet Pathol 14: 380

    PubMed  CAS  Google Scholar 

  93. Greene HSN (1959) Adenocarcinoma of the uterine fundus in the rabbit. Ann NY Acad Sci 75: 535

    PubMed  CAS  Google Scholar 

  94. Greene HSN (1965) Diseases of the rabbit. In: The Pathology of Laboratory Animals. Ribelin WE, McCoy JR (eds). Springfield, IL, Charles C Thomas, p 330

    Google Scholar 

  95. Greene HSN, Newton BL, Fisk AA (1947) Carcinoma of the vaginal wall in the rabbit. Cancer Res 7: 502

    Google Scholar 

  96. Greenwood AW (1967) Controlled environments and cancer incidence in the domestic fowl. In: Racial and Geographical Factors in Tumour Incidence. Shivas AA (ed). Medical Monograph 2. Edinburgh, University Press, p 241

    Google Scholar 

  97. Gregson RL, Lewis DJ, Abbott DP (1984) Spontaneous ovarian neoplasms of the laboratory rat. Vet Pathol 21: 292

    PubMed  CAS  Google Scholar 

  98. Griffith RW (1977) Bromocriptine and uterine neoplasia. Br Med J 2: 1605

    PubMed  CAS  Google Scholar 

  99. Hafez ESE (1973) The comparative anatomy of the mammalian cervix. In: The Biology of the Cervix. Blandau RJ, Moghissi K (eds). Chicago, University of Chicago Press, Chap 3

    Google Scholar 

  100. Hale HB, Weichert CK (1944) Ovarian tumors in adult rats following prepuberal administration of estrogens. Proc Soc Exp Biol Med 55: 201

    CAS  Google Scholar 

  101. Halloran P O’C (1955) A Bibliography of references to diseases in wild mammals and birds. Am J Vet Res 16 (12): 1

    Google Scholar 

  102. Hamilton CE (1947) The cervix uteri of the rat. Anat Rec 97: 47

    PubMed  CAS  Google Scholar 

  103. Handler AH (1965) Spontaneous lesions of the hamster. In: The Pathology of Laboratory Animals. Ribelin WE, McCoy JR (eds). Springfield, Ill, Charles C Thomas, p 210

    Google Scholar 

  104. Hayes HM, Young JL (1978) Epidemiologic features of canine ovarian neoplasms. Gynecol Oncol 6: 348

    PubMed  Google Scholar 

  105. Hecht F, McCaw BK, Patil S (1976) Ovarian teratomas and genetics of germ-cell formation. Lancet 2: 131

    Google Scholar 

  106. Herbst AL, Kurman RJ, Scully RE, Poskanzer DC (1972) Clear-cell adenocarcinoma of the genital tract in young females. N Engl J Med 287: 1259

    PubMed  CAS  Google Scholar 

  107. Hertz R (1971) Biological aspects of gestational neoplasms derived from trophoblast. Ann NY Acad Sci 172: 279

    PubMed  CAS  Google Scholar 

  108. Hiersche HD (1970) Funktionelle Morphologie des fetalen and kindlichen cervical Drusenfeldes in Uterus. Adv Anat Embryol Cell Biol 43: 1

    Google Scholar 

  109. Hilfrich J (1973) A new model for inducing malignant ovarian tumors in rats. Br J Cancer 28: 46

    PubMed  CAS  Google Scholar 

  110. Hiraki S (1971) Carcinogenic effect of N,N’-dimethylnitrosourea in Syrian hamsters. Gann 62: 321

    PubMed  CAS  Google Scholar 

  111. Homburger F (1972) Chemical carcinogenesis in Syrian hamsters. Prog Exp Tumor Res 16: 152

    PubMed  CAS  Google Scholar 

  112. Hori CG, Warren S, Patterson WB, Chute RN (1971) Gamma ray induction of malignant tumors in rats. Am J Pathol 65: 279

    PubMed  CAS  Google Scholar 

  113. Horning ES (1958) Carcinogenic action of androgens. Br J Cancer 64: 414

    Google Scholar 

  114. Howell JS (1963) The experimental production of vascular tumours in the rat. Br J Cancer 17: 663

    PubMed  CAS  Google Scholar 

  115. Howell JS, Marchant J, Orr JW (1954) The induction of ovarian tumours in mice with 9:10-dimethyl-1:2-benzanthracene. Br J Cancer 8: 635

    PubMed  CAS  Google Scholar 

  116. Huggins CB, Sugiyama T (1965) Production and prevention of two distinctive kinds of destruction of the adrenal cortex. Nature 206: 1310

    PubMed  CAS  Google Scholar 

  117. Hummel KP (1954) Induced ovarian tumors. J Natl Cancer Inst 15: 711

    PubMed  CAS  Google Scholar 

  118. Huseby RA, Thurlow S (1982) Effects of prenatal exposure of mice to “low dose” diethylstilbestrol and the development of adenomyosis associated with evidence of hyperprolactinemia. Am J Obstet Gynecol 144: 939

    PubMed  CAS  Google Scholar 

  119. Iglesias R (1974) Newer concepts in pathogenesis. Secondary endocrine and mammary malignancies as main signs of hormonal syndromes produced by endocrine tumors. Ann NY Acad Sci 230: 500

    PubMed  CAS  Google Scholar 

  120. lijima H, Nasu K, Taki I (1964) Comparative study of carcinogenesis in squamous and columnar epithelium of mouse uterus by string method of producing cervical carcinoma. Am J Obstet Gynecol 89: 946

    Google Scholar 

  121. Ingalls TH, Adams WM, Lurie MP, Ipsen J (1964) Natural history of adenocarcinoma of the uterus in the Phipps rabbit colony. J Natl Cancer Inst 33: 799

    PubMed  CAS  Google Scholar 

  122. Ishiwata L, Udagawa Y, Okumura H, Nozawa S (1978) Effects of progesterone on human endometrial carcinoma cells in vivo and in vitro. J Natl Cancer Inst 60: 947

    PubMed  CAS  Google Scholar 

  123. Jabara AG (1962) Induction of canine ovarian tumours by diethylstilbestrol and progesterone. Aust J Exp Biol Med Sci 40: 139

    PubMed  CAS  Google Scholar 

  124. Jacobs AJ, Curtis GL, Newland JR, Wilson RB, Ryan WL (1984) Chemical induction of ovarian epithelial carcinoma in mice. Gynecol Oncol 18: 177

    PubMed  CAS  Google Scholar 

  125. Jacobs BB, Huseby RA (1967) Neoplasms occurring in aged Fischer rats, with special reference to testicular, uterine and thyroid tumors. J Natl Cancer Inst 39: 303

    PubMed  CAS  Google Scholar 

  126. Jick H, Porter J, Morrison AS (1977) Relation between smoking and age at natural menopause. Lancet 1: 1354

    PubMed  CAS  Google Scholar 

  127. Jones EC, Krohn PL (1959) Influence of the anterior pituitary on the aging process in the ovary. Nature 183: 1155

    PubMed  CAS  Google Scholar 

  128. Jones EC, Krohn PL (1961) The relationships between age, numbers of oocytes and fertility in virgin and multiparous mice. J Endocrinol 21: 469

    PubMed  CAS  Google Scholar 

  129. Jones LA, Pacillas-Verjan R (1979) Transplantability and sex hormone responsiveness of cervicovaginal tumor derived from female BALB/cCrgl mice neonatally treated with ovarian steroids. Cancer Res 39: 2591

    PubMed  CAS  Google Scholar 

  130. Jull JW (1956) Hormones as promoting agents in mammary carcinogenesis. Acta Un Intl Cancer (Louvain) 12: 653

    CAS  Google Scholar 

  131. Jull JW (1969) Mechanism of induction of ovarian tumors in the mouse by 7,12-dimethylbenz[a]anthracene. VI. Effect of normal ovarian tissue on tumor development. J Natl Cancer Inst 42: 967

    PubMed  CAS  Google Scholar 

  132. Jull JW (1973) Ovarian tumorigenesis. Methods Cancer Res 7: 131

    CAS  Google Scholar 

  133. Jull JW, Jellink PH (1968) Mechanism of induction of ovarian tumors in the mouse by 7,12-dimethylbez[a]anthracene. IV. Uptake and retention of C14-DMBA by mouse and rat tissues. J Natl Cancer Inst 40: 707

    PubMed  CAS  Google Scholar 

  134. Jull JW, Russell A (1970) Mechanism of induction of ovarian tumors in the mouse by 7,12-dimethylbez[a]anthracene. VII. Relative activities of parent carcinogen and some of its metabolites. J Natl Cancer Inst 44: 841

    Google Scholar 

  135. Jull JW, Hawryluk A, Russell A (1968) Mechanism of induction of ovarian tumors in the mouse by 7,12-dimethylbenz[a]anthracene. III. Tumor induction in tissue culture. J Natl Cancer Inst 40: 687

    Google Scholar 

  136. Jurow HN (1943) Cyclic variations in the cervix of the guinea-pig. Am J Obstet Gynecol 45: 762

    Google Scholar 

  137. Kaminetzky HA (1966) Methylcholanthrene-induced cervical dysplasia and the sex steroids. Obstet Gynecol 27: 489

    PubMed  CAS  Google Scholar 

  138. Kammerman S, Demopoulos RI, Ross J (1977) Gonadotropin receptors in experimentally induced ovarian tumors in mice. Cancer Res 37: 2578

    PubMed  CAS  Google Scholar 

  139. Kaplan HS (1950) Influence of ovarian function on incidence of radiation-induced ovarian tumors in mice. J Natl Cancer Inst 11: 125

    PubMed  CAS  Google Scholar 

  140. Kato T, Yakashigi M, Tsunawaki A, Ide K (1974) Studies on experimental ovarian tumors developed in rats receiving chemical carcinogen 9,10-dimethyl-1,2 benzanthracene. Kurume Med J 21: 11

    Google Scholar 

  141. Katsuse K, Kakudo K, Sakurai M, Kitamura H (1978) Experimental teratoid tumor after fetectomy in mice. Gann 69: 447

    PubMed  CAS  Google Scholar 

  142. Kelly MG, O’Gara RW, Yancey ST, Botkin C (1958) Induction of tumors in rats with procarbazine hydrochloride. J Natl Cancer Inst 40: 1027

    Google Scholar 

  143. Kimura J (1978) Effect of progesterone on cell division in chemically induced endometrial hyperplasia and adenocarcinoma in mice. Cancer Res 38: 78

    PubMed  CAS  Google Scholar 

  144. Kirkman H (1972) Hormone-related tumors in Syrian hamsters. Prog Exp Tumor Res 16: 201

    PubMed  CAS  Google Scholar 

  145. Kirkman H, Algard FT (1970) Characteristics of an androgen/estrogen-induced uterine smooth muscle tumor of the Syrian hamster. Cancer Res 30: 794

    PubMed  CAS  Google Scholar 

  146. Kojima A, Taguchi O, Nishizuka A (1980) Induced oophoritis and gastritis in nude mice: A new approach to the localized type of autoimmunity. In: Proceedings of the 3rd International Workshop on Nude Mice. Reed ND (ed), New York, Gustav Fischer

    Google Scholar 

  147. Kojima A, Taguchi O, Sakakura T, Nishizuka Y (1979) Prevalent types of tumors developing in neonatally thymectomized mice. Gann 70: 839

    PubMed  CAS  Google Scholar 

  148. Kojima A, Yamashita K, Tsutsui K, Ishii S (1984) Development of “granulosa” cell tumors from intrasplenic testicular transplants in castrated NCI rats. Gann 75: 159

    PubMed  CAS  Google Scholar 

  149. Koprowska I, Bogacz J, Pentikas C, Stypulkowski W (1958) Induced cervical carcinoma of the mouse. A quantitative cytological method for evaluation of the neoplastic process. Cancer Res 18: 1186

    Google Scholar 

  150. Krarup T (1967) 9,10-Dimethyl-1,2-benzanthraceneinduced ovarian tumours in mice. Acta Pathol Microbiol Scand 70: 241

    Google Scholar 

  151. Krarup T (1969) Oocyte destruction and ovarian tumorigenesis after direct applications of a chemical carcinogen (9,10-dimethyl-1,2-benzanthracene) to the mouse ovary. Int J Cancer 4: 61

    PubMed  CAS  Google Scholar 

  152. Kullander S (1960) On tumor formation in gonadal and hypophyseal transplants into the anterior eye chambers of gonadectomised rats. Cancer Res 20: 1079

    PubMed  CAS  Google Scholar 

  153. Kushima K, Noda K, Makita M (1967) Experimental production of chorionic tumor in rabbits. Tohuko J Exp Med 91: 209

    CAS  Google Scholar 

  154. Kuwahara I (1967) Experimental induction of ovarian tumors in mice treated with a single administration of 7,12dimethylbenz[a]anthracene and its pathological observation. Gann 58: 253

    PubMed  CAS  Google Scholar 

  155. Lagerlof N, Boyd H (1953) Ovarian hypoplasia and other abnormal conditions in the sexual organs of cattle of the Swedish Highland breed: Results of postmortem examination of over 6000 cows. Cornell Vet 43: 64

    PubMed  CAS  Google Scholar 

  156. Lee S, Chandler JG, Broelsch CE, Ehara Y, Yen SS, Charters AC, Orloff MJ (1975) Intrasplenic ovarian neoplasm formation; direct measurement of FSH, LH, estrogens and progestins. Surg Forum 26: 149

    Google Scholar 

  157. Lee S, Condon JK, Chandler JG, Koopmans H, Ehara Y, Yen SS, Orloff MJ (1972) The effect of Eck fistula upon intrasplenic ovarian neoplasm formation. Surg Forum 23: 110

    PubMed  CAS  Google Scholar 

  158. Li MH, Gardner WU (1949) Further studies on the pathogenesis of ovarian tumors in mice. Cancer Res 9: 35

    PubMed  CAS  Google Scholar 

  159. Lick L, Kirschbaum A, Mixer H (1949) Mechanisms of induction of ovarian tumors by x-rays. Cancer Res 9: 532

    PubMed  CAS  Google Scholar 

  160. Linder D, McCaw BK, Hecht F (1975) Parthenogenic origin of benign ovarian teratomas. N Engl J Med 292: 63

    PubMed  CAS  Google Scholar 

  161. Lingeman CH (1974) Etiology of cancer of the human ovary: A review. J Natl Cancer Inst 53: 1603

    PubMed  CAS  Google Scholar 

  162. Lipschutz A (1957) Steroid Homeostasis, Hypophysis and tumorigenesis. Cambridge, Helfer and Sons

    Google Scholar 

  163. Lipschutz A, Vargas L (1941) Structure and origin of uterine and extragenital fibroids induced experimentally in the guinea pig by prolonged administration of estrogens. Cancer Res 1: 236

    CAS  Google Scholar 

  164. Lipschutz A, Iglesias R, Panasevich VI (1966) Experimental conditions under which contraceptive steroids may become toxic. Nature 212: 686

    CAS  Google Scholar 

  165. Lipschutz A, Iglesias R, Panasevich VI, Salinas S (1967) Granulosa cell tumours induced in mice by progesterone. Br J Cancer 21: 144

    PubMed  CAS  Google Scholar 

  166. Lipschutz A, Iglesias R, Panasevich VI, Salinas S (1967) Pathological changes induced in the uterus of mice with the prolonged administration of progesterone and 19-norcontraceptives. Br J Cancer 21: 160

    PubMed  CAS  Google Scholar 

  167. Lipschutz A, Iglesias R, Panasevich VI, Socorro S (1967) Ovarian tumours and other ovarian changes induced in mice by two 19-nor-contraceptives. Br J Cancer 21: 153

    PubMed  CAS  Google Scholar 

  168. Lipschutz A, Iglesias R, Rojas G, Cerisola H (1959) Spontaneous tumorigenesis in aged guinea pigs. Br J Cancer 13: 486

    PubMed  CAS  Google Scholar 

  169. London WT, Nahmias AJ, Naib ZM, Fucillo DA, Ellen-berg JH, Sever JL (1974) A nonhuman primate model for the study of cervical oncogenic potential of herpes simplex virus type 2. Cancer Res 34: 1118

    PubMed  CAS  Google Scholar 

  170. Lorenz E (1950) Some biologic effects of long continued radiation. AJR 63: 176

    CAS  Google Scholar 

  171. Malinin GI, Malinin IM (1972) Age-related spontaneous uterine lesions in mice. J Gerontol 27: 193

    PubMed  CAS  Google Scholar 

  172. Marchant J (1957) The chemical induction of ovarian tumours in mice. Br J Cancer 11: 452

    PubMed  CAS  Google Scholar 

  173. Marchant J (1959) Breast and ovarian tumours in F1 C57B1 x IF hybrid mice after reciprocal exchange of ovaries between normal females and females pretreated with 9,10dimethyl-1,2-benzanthracene. Acta Un Int Contr Cancrum 15: 196

    CAS  Google Scholar 

  174. Marchant J (1960) Personal observation

    Google Scholar 

  175. Mardones E, Iglesias R, Lipschutz A (1955) Granulosa cell tumours in intrasplenic ovarian grafts with intrahepatic metastases, in guinea pigs at five years after grafting. Br J Cancer 9: 409

    PubMed  CAS  Google Scholar 

  176. Martin CB Jr, Misenhimer HR, Ramsey EM (1970) Ovarian tumors in rhesus monkeys (Macaca mulatta): Report of three cases. Lab Anim Sci 20: 686

    Google Scholar 

  177. Mattem J, Wayss K, Volm M (1984) Effect of five antineoplastic agents on tumor xenografts with different growth rates. J Natl Cancer Inst 72: 1335

    Google Scholar 

  178. Mattison DR, Thorgeirsson SS (1978) Smoking and industrial pollution and their effects on menopause and ovarian cancer. Lancet 1: 187

    PubMed  CAS  Google Scholar 

  179. McClure HM, Graham CE (1973) Malignant uterine mesotheliomas in squirrel monkeys following diethylstilbestrol administration. Lab Anim Sei 23: 493

    CAS  Google Scholar 

  180. McEntee K, Nielson SW (1976) Tumours of the female genital tract. Bull WHO 53: 203

    PubMed  Google Scholar 

  181. McLachlan JA (1979) Transplacental effects of diethylstilbestrol in mice. Natl Cancer Inst Monog 51: 67

    Google Scholar 

  182. Meier H, Myers DD, Fox RR, Laird CW (1970) Occurrence, pathological features, and propagation of gonadal teratomas in inbred mice and rabbits. Cancer Res 30: 30

    PubMed  CAS  Google Scholar 

  183. Meisels A (1966) Effect of sex hormones on the carcinogenic action of dimethylbenzanthracene on the uterus of intact and castrated mice. Cancer Res 26: 757

    PubMed  CAS  Google Scholar 

  184. Meissner WA, Sommers SC, Sherman G (1957) Endometrial hyperplasia, endometrial carcinoma and endometriosis produced experimentally by estrogen. Cancer 10: 500

    PubMed  CAS  Google Scholar 

  185. Menczer J, Komarov H, Shenbaum M, Insler V, Czernobilsky B (1977) Attempted induction of granulosa cell tumors in BALB/c mice with gonadotropin administration. Gynecol Invest 8: 314

    PubMed  CAS  Google Scholar 

  186. Merriam J, Easterday C, McKay DG, Hertig AT (1960) Experimental production of endometrial carcinoma in the rabbit. Obstet Gynecol 16: 253

    Google Scholar 

  187. Miller EC, Fletcher TL, Margreth A, Miller JA (1962) The carcinogenicities of derivatives of fluorene and biphenyl:fluoro derivatives as probes for active sites in 2acetylaminofluorene. Cancer Res 22: 1002

    CAS  Google Scholar 

  188. Miller OJ, Gardner WU (1954) The role of thyroid function and food intake in experimental ovarian tumorigenesis in mice. Cancer Res 14: 220

    PubMed  CAS  Google Scholar 

  189. Miyamoto M (1971) Experimental induction of choriocarcinoma in rats. Gann 62: 55

    PubMed  CAS  Google Scholar 

  190. Mody JK (1960) The action of four carcinogenic hydrocarbons on the ovaries of IF mice and the histogenesis of induced tumours. Br J Cancer 14: 256

    PubMed  CAS  Google Scholar 

  191. Moon HD, Simpson ME, Li CH, Evans HM (1950) Neoplasms in rats and mice treated with pituitary growth hormone. III. Reproductive organs. Cancer Res 10: 549

    Google Scholar 

  192. Mori K (1964) Induction of pulmonary and uterine tumors in rats by subcutaneous injections of 4-nitroquinoline-1oxide. Gann 55: 277

    PubMed  CAS  Google Scholar 

  193. Mori T, Nagasawa H, Takahashi S (1981) The induction of adenomyosis in mice by intrauterine pituitary isografts. Life Sci 29: 1277

    PubMed  CAS  Google Scholar 

  194. Morris HP, Velat CA, Wagner BP (1957) Carcinogenicity of some ingested acetylated mono-and diaminobiphenyl compounds in the rat. J Natl Cancer Inst 18: 101

    PubMed  CAS  Google Scholar 

  195. Morris HP, Wagner BP, Ray FE, Stewart HL, Snell KC (1963) Carcinogen effects of N,N’-2,7-fluorenylenebis2,2, 2-trifluoroacetamide (2,7-FAA-F) administered orally to Buffalo strain rats. J Natl Cancer Inst 30: 143

    Google Scholar 

  196. Mossman HW (1973) The embryology of the cervix. In: The Biology of the Cervix. Blandau RJ, Moghissi K (eds). Chicago, University of Chicago Press, Chap 2

    Google Scholar 

  197. Muhlbock 0 (1953) Ovarian tumours in mice in parabiotic union. Acta Endocrinol (Copenh) 12: 105

    Google Scholar 

  198. Muhlbock 0 (1954) On the genesis of ovarian tumours. Experiments with mice in parabiotic union. Acta Un Int Cancr (Louvain) 10: 141

    Google Scholar 

  199. Munoz N (1973) Effect of herpesvirus type 2 and hormone imbalance on the uterine cervix of the mouse. Cancer Res 33: 1504

    PubMed  CAS  Google Scholar 

  200. Murphy ED (1953) Studies on carcinogen-induced carcinoma of the cervix in mice. Am J Pathol 29: 608

    Google Scholar 

  201. Murphy ED (1961) Carcinogenesis of the uterine cervix in mice: Effect of diethylstilbestrol after limited application of 3-methylcholanthrene. J Natl Cancer Inst 27: 611

    PubMed  CAS  Google Scholar 

  202. Murphy ED (1966) Characteristic tumors. In: Jackson Laboratory. Biology of the Laboratory Mouse, 2nd ed. Green EL (ed). New York, McGraw-Hill, Chap 27

    Google Scholar 

  203. Murphy ED (1972) Hyperplastic and early neoplastic changes in the ovaries of mice after genic deletion of germ cells. J Natl Cancer Inst 48: 1283

    PubMed  CAS  Google Scholar 

  204. Murphy ED (1980) Major experimental models: Histogenesis and evaluation. In: Biology of Ovarian Neoplasia. UICC Technical Report Series, Murphy ED, Beamer WG (eds). Geneva, Union Internationale Contre le Cancer, Vol 50, p 6

    Google Scholar 

  205. Murphy ED, Beamer WG (1973) Plasma gonadotropin levels during early stages of ovarian tumorigenesis in mice of the Wx/W° genotype. Cancer Res 33: 721

    PubMed  CAS  Google Scholar 

  206. Murthy ASK, Russfield AB (1970) Endocrine changes in two strains of mice exposed to constant illumination. Endocrinology 86: 914

    PubMed  CAS  Google Scholar 

  207. Napalkov NP, Alexandrov VA (1968) On the effects of blastomogenic substance on the organism during embryo-genesis. Z Krebsforsch 71: 32

    PubMed  CAS  Google Scholar 

  208. Napalkov NP, Anisimov VN (1979) Transplacental effect of diethylstilbestrol in female rats. Cancer Lett 6: 107

    PubMed  CAS  Google Scholar 

  209. Nelson LW, Kelly WA, Weikel JH (1972) Mesovarial leiomyomas in rats in a chronic toxicity study of mesuprine hydrochloride. Toxicol Appl Pharmacol 23: 731

    PubMed  CAS  Google Scholar 

  210. Nelson WO (1939) Atypical uterine growths produced by prolonged adminstration of estrogenic hormones. Endocrinology 24: 50

    CAS  Google Scholar 

  211. Nishizuka Y, Sakakura T (1971) Ovarian dysgenesis induced by neonatal thymectomy in the mouse. Endocrinology 89: 886

    PubMed  CAS  Google Scholar 

  212. Nishizuka Y, Sakakura T (1971) Effect of combined removal of thymus and pituitary on post-natal ovarian follicular development in the mouse. Endocrinology 89: 902

    PubMed  CAS  Google Scholar 

  213. Nishizuka Y, Sakakura T, Taguchi O (1979) Mechanism of ovarian tumorigenesis in mice after neonatal thymectomy. Natl Cancer Inst Monog 51: 89

    Google Scholar 

  214. Nishizuka Y, Tanaka Y, Sakakura T, Kojima A (1972) Frequent development of ovarian tumors from dysgenetic ovaries of neonatally thymectomised mice. Gann 63: 139

    PubMed  CAS  Google Scholar 

  215. Noble RL, Hochachka BC, King D (1975) Spontaneous and estrogen-produced tumors in NB rats and their behavior after transplantation. Cancer Res 35: 766

    PubMed  CAS  Google Scholar 

  216. Nomura T (1976) Comparison of tumour susceptibility among various organs of foetal, young and adult ICB/Jcl mice. Br J Cancer 33: 521

    PubMed  CAS  Google Scholar 

  217. Nomura T (1973) Carcinogenesis by urethane via mother’s milk and its enhancement of transplacental carcinogenesis in mice. Cancer Res 33: 1677

    PubMed  CAS  Google Scholar 

  218. Nomura T, Okamoto E (1972) Transplacental carcinogenesis by urethane in mice; teratogenesis and carcinogenesis in relation to organogenesis. Gann 63: 731

    PubMed  CAS  Google Scholar 

  219. Norris HJ, Gardner FM, Taylor HB (1969) Pathology of feline ovarian neoplasms. J Pathol 97: 138

    PubMed  CAS  Google Scholar 

  220. Norris JH, Taylor HB, Gardner FM (1968) Equine ovarian granulosa tumours. Vet Rec 82: 419

    Google Scholar 

  221. Oakberg EF (1966) Effect of 25R of x-rays at 10 days of age on oocyte numbers and fertility of female mice. In: Radiation and Aging. Lindop PJ, Sacher GA (eds). London, Taylor and Francis, p 293

    Google Scholar 

  222. O’Shea JD, Jabara AG (1971) Proliferative lesions of serous membranes in ovariectomised female and entire male dogs after stilboestrol administration. Vet Pathol 8: 81

    PubMed  Google Scholar 

  223. Palayoor T, Batra UK, Batra BK (1977) Radiation-induced pathogenesis in the progeny of x-irradiated female mice. Indian J Exp Biol 15: 163

    PubMed  CAS  Google Scholar 

  224. Pan SC, Gardner WU (1948) Induction of malignant tumors by methycholanthrene in transplanted uterine cornua and cervixes of mice. Cancer Res 8: 337

    PubMed  CAS  Google Scholar 

  225. Pantelouris EM (1973) Athymic development in the mouse. Differentiation 1: 437

    PubMed  CAS  Google Scholar 

  226. Payne S (1958) The pathological effects of the intraperitoneal injection of 3,4-benzopyrene into rats and mice. Br J Cancer 12: 65

    PubMed  CAS  Google Scholar 

  227. Peckham BM, Greene RR (1952) Experimentally produced granulosa cell tumors in rabbits. Cancer Res 12: 654

    PubMed  CAS  Google Scholar 

  228. Peters H (1969) Effects of radiation in early life on the morphology and reproductive function of the mouse ovary. Adv Reprod Physiol 4: 149

    Google Scholar 

  229. Pfeiffer CA (1949) Development of leiomyomas in female rats with an endocrine imbalance. Cancer Res 9: 277

    PubMed  CAS  Google Scholar 

  230. Pfeiffer CA (1949) Adenocarcinoma in the uterus of an endocrine imbalance female rat. Cancer Res 9: 347

    PubMed  CAS  Google Scholar 

  231. Pierson H (1934) Experimental production of uterine enlargement with cancer through ovarian hormones. Z Krebsforsch 41: 103

    Google Scholar 

  232. Reagen JW, Wentz BW, Hachicao N (1955) Induced cancer of the cervix uteri of the mouse. Arch Pathol 6: 451

    Google Scholar 

  233. Reboud S, Pageant G (1973) Co-carcinogenic effect of progesterone on 20-methylcholanthrene-induced cervical carcinoma in mice. Nature 241: 398

    PubMed  CAS  Google Scholar 

  234. Rehm S, Dierksen D, Deerberg F (1984) Spontaneous ovarian tumors in Han:NMR1 mice: Histologic classification, incidence and influence of food restriction. J Natl Cancer Inst 72: 1383

    Google Scholar 

  235. Reuber MD (1960) Endometrial sarcomas of the uterus and carcinosarcomas of the submaxillary salivary glands in castrated A x C strain female rats receiving N,N’fluorenyldiacetamide and norethandrolone. J Natl Cancer Inst 25: 1141

    PubMed  CAS  Google Scholar 

  236. Rogers JB, Blumenthal HT (1960) Studies of guinea pig tumors. I. Report of fourteen spontaneous guinea pigs tumors with a review of the literature. Cancer Res 20: 191

    Google Scholar 

  237. Rowe SE, Simmons JL, Ringler DH, Lay DM (1974) Spontaneous neoplasms in aging Gerbillinae. A summary of forty-four neoplasms. Vet Pathol 11: 38

    Google Scholar 

  238. Rubio CA, Lagerlof B (1974) Studies on the histogenesis of experimentally induced cervical carcinoma. Acta Pathol Microbiol Scand [A] 82: 153

    CAS  Google Scholar 

  239. Russell ES, Fekete E (1968) Analysis of W-series pleiotropism in the mouse: Effect of W“W” substitution on definitive germ cells and on ovarian tumorigenesis. J Natl Cancer Inst 21: 365

    Google Scholar 

  240. Rustia M (1979) Role of hormone imbalance in transplacental carcinogenesis in Syrian golden hamsters by sex hormones. Natl Cancer Inst Monog 51: 77

    CAS  Google Scholar 

  241. Sakashita S, Tsukada Y, Nakamura K, Tsuji I, Hirai H (1977) Experimental yolk sac tumors produced by fetectomy without virus infection in rats. Int J Cancer 20: 83

    PubMed  CAS  Google Scholar 

  242. Sawada M, Matsui Y, Okudaira Y (1983) Effect of human lymphoblastoma interferon on human yolk sac tumors in nude mice. Biken J 26: 169

    PubMed  CAS  Google Scholar 

  243. Sawada M, Matsui Y, Hayakawa K, Nishiura H, Okudaira Y, Taki L (1982) Human gynecologic cancers hetero transplanted into athymic nude rats. Gynecol Oncol 13: 220

    PubMed  CAS  Google Scholar 

  244. Scarpelli DG, Haam E von (1955) Experimental carcinoma of the cervix: A comparative cytologic and histologic study. Cancer Res 15: 449

    Google Scholar 

  245. Scarpelli DG, Haam E von (1957) Experimental carcinoma of the cervix in the mouse. Am J Pathol 33: 1059

    PubMed  CAS  Google Scholar 

  246. Schoental R (1968) Pathologic lesions, including tumors, in rats after 4,4’-diaminodiphenylmethane and alphabutyrolactone. Isr J Med Sci 4: 1146

    PubMed  CAS  Google Scholar 

  247. Schoental R (1969) Carcinogenic action of elaiomycin in rats. Nature 221: 765

    PubMed  CAS  Google Scholar 

  248. Seibold HR, Wolf RH (1973) Neoplasms and proliferative lesions in 1065 nonhuman primate necropsies. Lab Anim Sci 23: 53

    Google Scholar 

  249. Sekiya S, Takamizawa H, Wang F, Takane T, Kuwata T (1972) In vivo and in vitro studies on uterine adenocarcinoma of the rat induced by 7,12-dimethlybenz[a]anthracene. Am J Obstet Gynecol 111: 691

    Google Scholar 

  250. Sekiya S, Kikuchi Y, Katoh T, Kobayashi W, Takeda B, Takamizawa H (1979) Effect of ovariectomy, adrenalectomy, and hypophysectomy on carcinogenesis of the endometrium by 7,12-dimethlybenz[a]anthracene in rats. Gynecol Oncol 7: 281

    PubMed  CAS  Google Scholar 

  251. Sekiya S, Endoh N, Kikuchi Y, Katoh T, Matsura A, Iwasawa H, Takeda B, Takamizawa H (1979) In vivo and in vitro studies of experimental ovarian adenocarcinoma in rats. Cancer Res 39: 1108

    PubMed  CAS  Google Scholar 

  252. Sever JL (1973) Herpes virus and cervical cancer studies in experimental animals. Cancer Res 33: 1509

    PubMed  CAS  Google Scholar 

  253. Shen CN (1971) Experimental induction of placental tumor in the guinea pig. Nagoya Med J 17: 33

    PubMed  CAS  Google Scholar 

  254. Shintani S, Glass LE, Page EW (1966) Studies of induced malignant tumors of placental and uterine origin in the rat. II. Induced tumors and their pathogenesis with special reference to choriocarcinoma. Am J Obstet Gynecol 95: 550

    Google Scholar 

  255. Shintani S, Glass LE, Page EW (1966) Studies of induced malignant tumors of placental and uterine origin in the rat. III. Identification of experimentally induced choriocarcinoma by detection of placenta hormone. Am J Obstet Gynecol 95: 559

    Google Scholar 

  256. Shisa H, Nishizuka Y (1968) Unilateral development of ovarian tumor in thymectomized Swiss mice following a single injection of 7,12-dimethlybenz[a]anthracene at neonatal stage. Br J Cancer 22: 70

    PubMed  CAS  Google Scholar 

  257. Shulze F (1960) Spontantumoren der Schadelhohle and Genitalorgane hei Sprague-Dawley and Bethesda-black Ratten. Z Krebsforsch 64: 78

    Google Scholar 

  258. Singh KB (1969) Induction of polycystic ovarian disease in rats by continuous light. I. The reproductive cycle, organ weights and histology of the ovaries. Am J Obstet Gynecol 103: 1078

    PubMed  CAS  Google Scholar 

  259. Skreb N, Svajger A, Levak-Svajger B (1971) Growth and differentiation of rat egg cylinders under the kidney capsule. J Embryol Exp Morphol 25: 47

    PubMed  CAS  Google Scholar 

  260. Slye M, Holmes MF, Wells HG (1920) Primary spontaneous tumors of the ovary in mice. J Cancer Res 5: 205

    Google Scholar 

  261. Snell K (1925) Spontaneous lesions of the rat. In: The Pathology of Laboratory Animals. Ribelin WE, McCoy JP (eds). Springfield, Ill, Charles C Thomas, p 241

    Google Scholar 

  262. Sobis H, Vandeputte M (1975) Sequential morphological study of teratomas derived from displaced yolk sac. Dev Biol 45: 276

    PubMed  CAS  Google Scholar 

  263. Solter D, Sreb N, Damjanov I (1970) Extrauterine growth of mouse egg-cyclinders results in malignant teratoma. Nature 227: 503

    PubMed  CAS  Google Scholar 

  264. Sommers SC, Meissner WA (1957) Host relationship in experimental endometrial carcinoma. Cancer 10: 510

    PubMed  CAS  Google Scholar 

  265. Staats J (1964) Standardised nomenclature for inbred strains of mice. Third listing. Cancer Res 24: 147

    PubMed  CAS  Google Scholar 

  266. Steel GG, Courtenay VD, Roston AY (1978) Improved immunosuppression techniques for the xenografting of human tumors. Br J Cancer 37: 224

    PubMed  CAS  Google Scholar 

  267. Stein-Werblowsky R (1960) Induction of a choriocarcinoma in the rat. Nature 186: 980

    PubMed  CAS  Google Scholar 

  268. Stein-Werblowsky R (1960) Induction of cancer in the cervix uteri in relation to the oestrus cycle. Br J Cancer 14: 300

    PubMed  CAS  Google Scholar 

  269. Stein-Werblowsky R (1977) The induction of precancerous changes in the uterine epithelium of the rat: The role of spermatozoa. Gynecol Oncol 5: 251

    PubMed  CAS  Google Scholar 

  270. Stevens LC (1980) The origin and development of ovarian teratomas in mice. In: Biology of Ovarian Neoplasia. UICC Technical Report Series, Geneva, UICC, Vol 50, p 74

    Google Scholar 

  271. Stevens LC, Varnum DS (1974) The development of teratomas from parthenogenetically activated ovarian mouse eggs. Dev Biol 37: 369

    PubMed  CAS  Google Scholar 

  272. Strong LC, Gardner WU, Hill RT (1937) Production of estrogenic hormone by a transplantable ovarian carcinoma. Endocrinology 21: 268

    CAS  Google Scholar 

  273. Suntzeff V, Burns EL, Moskop M, Loeb L (1938) On proliferative changes taking place in the epithelium of vagina and cervix of mice with advancing age and under influence of experimentally administered estrogenic hormones. Am J Cancer 32: 256

    PubMed  CAS  Google Scholar 

  274. Symeonidis A (1954) Tumors induced by 2-acetylaminofluorene in virgin and breeding females of five strains of rats and their offspring. J Natl Cancer Inst 15: 539

    PubMed  CAS  Google Scholar 

  275. Takamizawa H, Wong K (1973) Effect of anticancer drugs on uterine carcinogenesis. Obstet Gynecol 41: 701

    PubMed  CAS  Google Scholar 

  276. Taki I, lijima H (1963) A new method of producing endometrial cancer in mice. Am J Obstet Gynecol 87: 926

    PubMed  CAS  Google Scholar 

  277. Tannenbaum A, Vessilinovitch SD, Maltoni C, Mitchell DS (1962) Multipotential carcinogenicity of urethan in the Sprague-Dawley rat. Cancer Res 22: 1362

    PubMed  CAS  Google Scholar 

  278. Teutscher R (1959) Ein Plattenepithelkrebs der Schamlippe der Stute. Deutsch Tierarztl Wachenschr 66: 567

    Google Scholar 

  279. Thiery M (1936) Ovarian teratoma in the mouse. Br J Cancer 17: 231

    Google Scholar 

  280. Thorpe P, Isaac P (1977) Long-term use of bromocriptine. Med J Aust 2: 721

    PubMed  CAS  Google Scholar 

  281. Tokita H, Tanaka N, Sekimoto K, Heno T, Okamoto K, Fugimura S (1980) Experimental model for combination chemotherapy with metronidazole using human uterine cervical carcinomas transplanted into nude mice. Cancer Res 40: 4287

    PubMed  CAS  Google Scholar 

  282. Tomatis L (1979) Prenatal exposure to chemical carcinogens and its effect on subsequent generations. Natl Cancer Inst Monog 51: 159

    Google Scholar 

  283. Tsutae K, Saito T, Hura I, Abe N, Shinoda M, Miyashita I, Nomura Y, Shirota K, Saito Y (1982) Primary ovarian tumors in swine. Bull Azabu Univ Vet Med 3: 147

    Google Scholar 

  284. Turusov VS, Bazlova LS, Lanko NS (1977) Nonepithelial uterine tumours induced in CBA mice by 1,2-dimethylhydrazine. Cancer Lett 3: 37

    PubMed  CAS  Google Scholar 

  285. Uematsu K, Huggins CB (1968) Induction of leukaemia and ovarian tumors in mice by pulse-doses of aromatic hydrocarbons. Mol Pharmacol 4: 427

    PubMed  CAS  Google Scholar 

  286. Urich RL (1984) Tumor induction in BALB/c mice after fractionated or protracted exposure to fission-spectrum neutrons. Radiat Res 97: 587

    Google Scholar 

  287. Upton AC, Kimball AW, Furth J, Christenberry KW, Benedict WH (1960) Some delayed effects of atom-bomb radiations in mice. Cancer Res 20 (8) 1

    PubMed  Google Scholar 

  288. Vandeputte M, Eyssen H, Sobis H, DeSomer P (1974) Induction of polyoma tumors in athymic nude mice. Cancer 14: 445

    CAS  Google Scholar 

  289. Vandeputte M, Sobis H, Billiau A, van de Maele B, Leyter R (1973) In utero tumor induction by murine sarcoma virus (Moloney) in the rat. I. Biological characteristics. Int J Cancer 11: 536

    Google Scholar 

  290. Van Nie R, Smit GMJ, Muhlbock O (1962) The induction of uterine tumors in mice treated with testosterone. Acta Un Contr Cancr 18: 194

    Google Scholar 

  291. Vellios F, Griffin J (1955) The pathogenesis of dimethylbenz[a]-anthracene-induced carcinoma of the cervix in rats. Cancer Res 17: 364

    Google Scholar 

  292. Vesselinovich SD, Rao KUN, Mihailovich N (1979) Neoplastic response of mouse tissues during perinatal age periods and its significance in chemical carcinogenesis. Natl Cancer Inst Monog 51: 239

    Google Scholar 

  293. Vesselinovich SD, Mihailovich N, Rao KV, Itze L (1971) Perinatal carcinogenesis by urethane. Cancer Res 31: 2143

    Google Scholar 

  294. Vink HH (1970) Ovarian teratomas in guinea pigs: A report of ten cases. J Pathol 102: 180

    PubMed  CAS  Google Scholar 

  295. Walker BE (1984) Tumors of female offspring of mice exposed prenatally to diethylstilbestrol. J Natl Cancer Inst 73: 133

    PubMed  CAS  Google Scholar 

  296. Ward BC, Moore W Jr (1969) Spontaneous lesions in a colony of Chinese hamsters, Cricetulus griseus. Lab Anim Sci 19: 516

    PubMed  CAS  Google Scholar 

  297. Warren S, Gates 0 (1941) Spontaneous and induced tumors of the guinea pig. Cancer Res 1: 65

    Google Scholar 

  298. Weisbroth SH (1974) Neoplastic diseases. In: The Biology of the Laboratory Rabbit. Weisbroth SH, Flatt RE, Kraus AL (eds). New York, Academic Press, p 331

    Google Scholar 

  299. Willis RA (1962) Ovarian teratomas in guinea pigs. J Pathol Bacteriol 84: 237

    PubMed  CAS  Google Scholar 

  300. Yeh SDJ, Woo SK (1980) Gallium uptake in heterotransplanted human choriocarcinoma and ovarian carcinoma in nude mice. Proc Soc Exp Biol Med 165: 361

    PubMed  CAS  Google Scholar 

  301. Yong HY, Campbell JS (1965) Evolution of dysplasia of the uterine cervix and vagina induced by low dosages of carcinogen in mice. Obstet Gynecol 26: 91

    Google Scholar 

  302. Zaino RJ, Satyaswaroop PG, Mortel R (1984) Morphology of human uterine cancer in nude mice. Effects of hormone and antihormone treatment. Arch Pathol Lab Med 108: 571

    Google Scholar 

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Marchant, J. (1987). Animal Models for Tumors of the Female Genital Tract. In: Kurman, R.J. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-1942-0_26

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