Abstract
The history of humans is, in large part, a chronicle of their quest for food. Humans can feast when food is available and fast during caloric deprivation without serious consequences. The capability of humans to survive marked extremes in caloric intake depends on the ability (1) to selectively oxidize and excrete certain nitrogenous metabolites, (2) to store carbohydrate and lipid metabolites in an economical form during caloric excess, and (3) to spare protein and to selectively mobilize and oxidize substrates derived from fat stores during caloric deprivation.
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Addendum
Sims, E.A.H. (1976). Experimental obesity, dietaryinduced thermogenesis, and their clinical implications. Clinics Endocrinol. Metab. 5: 377–395.
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Owen, O.E., Reichard, G.A., Patel, M.S., Boden, G. (1979). Energy Metabolism in Feasting and Fasting. In: Klachko, D.M., Anderson, R.R., Heimberg, M. (eds) Hormones and Energy Metabolism. Advances in Experimental Medicine and Biology, vol 111. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0734-2_8
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DOI: https://doi.org/10.1007/978-1-4757-0734-2_8
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