Abstract
Several investigators have found that basal forebrain neurons in the area of the nucleus basalis and substantia innominata respond to cues that signal the availability of reinforcement (DeLong, 1971; Mitchell et al., 1987; Richardson and DeLong, 1986, 1988; Rolls et al., 1979; Travis and Sparks, 1968; Wilson and Rolls, 1990a, 1990b). The reinforcement-related or conditioning-related responses of such basal forebrain neurons do not depend upon the sensory modality of the signal cue (Wilson and Rolls, 1990a). It is also known that cortical neurons respond to conditioned stimuli applied during similar behavioral paradigms (Aou et al., 1983; Boyd et al., 1982; Fuster et al., 1982; Kojima and Goldman-Rakic, 1982; Mauritz and Wise, 1986; Peterson, 1986; Watanabe, 1990), suggesting a possible relationship between cortical neuron responses and activity of basal forebrain neurons.
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Aou, S., Oomura, Y., and Nishino, H., 1983, Influence of acetylcholine on neuronal activity in monkey orbitofrontal cortex during bar press feeding task, Brain Res., 275:178.
Ashe, J.H., McKenna, T.M., and Weinberger, N.M., 1989, Cholinergic modulation of frequency receptive fields in auditory cortex: II. Frequency-specific effects of anticholinesterases provide evidence for a modulatory action of endogenous ACh, Synapse. 4:44.
Boyd, E.H., Boyd, E.S., and Brown, L.E., 1982, Precentral cortex unit activity during the M-wave and contingent negative variation in behaving squirrel monkeys, Exp. Neurol., 75:535.
Cornwall, J., Cooper, J.D., and Phillipson, O.T., 1990, Projections to the rostral reticular thalamic nucleus in the rat, Exp. Brain Res., 80:157.
Delong, M.R., 1971, Activity of pallidal neurons during movement, J. Neurophysiol., 34:414.
Donoghue, J.P., and Carroll, K.L., 1987, Cholinergic modulation of sensory responses in rat primary somatic sensory cortex. Brain Res., 408:367.
Ebenezer, I.S., 1983, Cortical slow potentials recorded in rats anesthetized with urethane are affected by nicotine, British J. Pharmacol. Proceed. Suppl., 79:270P.
Fuster, J.M., Bauer, R.H., and Jervey, J.P., 1982, Cellular discharge in the dorsolateral prefrontal cortex of the monkey in cognitive tasks, Exp. Neurol., 77:679.
Greuel, J.M., Luhmann, H.J., and Singer, W., 1988, Pharmacological induction of use-dependent receptive field modifications in the visual cortex. Science. 242:74.
Haring, J.H., and Wang, R.Y., 1986, The identification of some sources of afferent input to the rat nucleus basalis magnocellularis by retrograde transport of horseradish peroxidase. Brain Res., 366:152.
Harrison, J.B., Buchwald, J.S., Kaga, K., Woolf, N.J., and Butcher, L.L., 1988, Cat ‘P300’ disappears after septal lesions, Electroencepha- logr. Clin. Neurophysiol., 69:55.
Inoue, M., Oomura, Y., Nishino, H., Aou, S., Sikdar, S.K., Hynes, M., Mizuno, Y., and Katabuchi, T., 1983, Cholinergic role in monkey dorsolateral prefrontal cortex during bar-press feeding behavior, Brain Res., 278:185.
Jones, B.E., and Cuello, A.C., 1989, Afferents to the basal forebrain cholinergic cell area from pontomesencephalic catecholamine, serotonin, and acetylcholine neurons, Neuroscience. 31:37.
Jourdain, A., Semba, K., and Fibiger, H.C., 1989, Basal forebrain and mesopontine tegmental projections to the reticular thalamic nucleus: An axonal collateralization and immunohistochemical study in the rat. Brain Res., 505:55.
Kojima, S., and Goldman-Rakic, P.S., 1982, Delay-related activity of prefrontal neurons in Rhesus monkeys performing delayed response. Brain Res., 248:43.
Levey, A.I., Wainer, B.H., Rye, D.B., Mufson, E.J., and Mesulam, M.-M., 1984, Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons, Neuroscience, 13:341.
Lénard, L., Oomura, Y., Nakano, Y., Aou, S., and Nishino, H., 1989, Influence of acetylcholine on neuronal activity of monkey amygdala during bar press feeding behavior, Brain Res., 500:359.
Mauritz, K.-H., and Wise, S.P., 1986, Premotor cortex of the rhesus monkey: neuronal activity in anticipation of predictable environmental events, Exp. Brain Res., 61:229.
McCormick, D.A., 1989, Cholinergic and noradrenergic modulation of thalamocortical processing, TINS. 12:215.
McKenna, T.M, Ashe, J.H., Hui, G.K., and Weinberger, N.M., 1988, Muscarinic agonists modulate spontaneous and evoked unit discharge in auditory cortex of cat. Synapse. 2:54.
McKenna, T.M., Ashe, J.H., and Weinberger, N.M., 1989, Cholinergic modulation of frequency receptive fields in auditory cortex: I. Frequency-specific effects of muscarinic agonists. Synapse., 4:30.
Metherate, R., Tremblay, N., and Dykes, R.W., 1988a, The effects of acetylcholine on response properties of cat somatosensory cortical neurons, J. Neurophysiol., 59:1231.
Metherate, R., Tremblay, N., and Dykes, R.W., 1988b, Transient and prolonged effects of acetylcholine on responsiveness of cat somatosensory cortical neurons, J. Neurophysiol., 59:1253.
Metherate, R., and Weinberger, N.M., 1989, Acetylcholine produces stimulus-specific receptive field alterations in cat auditory cortex, Brain Res., 480:372.
Mitchell, S.J., Richardson, R.T., Baker, F.H., and Delong, M.R., 1987, The primate nucleus basalis of Meynert: neuronal activity related to a visuomotor tracking task, Exp. Brain Res., 68:506.
Mogenson, G.J., Ciriello, J., Garland, J., and Wu, M., 1987, Ventral pallidum projections to mediodorsal nucleus of the thalamus: an anatomical and electrophysiological investigation in the rat, Brain Res., 404:221.
Mogenson, G.J., Swanson, L.W., and Wu, M., 1983, Neural projections from nucleus accumbens to globus pallidus, substantia innominata, and lateral preoptic-lateral hypothalamic area: an anatomical and electrophysiological investigation in the rat, J. Neurosci., 3:189.
Peterson, S.L., 1986, Prefrontal cortex neuron activity during a discriminative conditioning paradigm in unanesthetized rats, Intern. J. Neuroscience., 29:245.
Pirch, J.H., 1977, Amphetamine effects on brain slow potentials associated with discrimination in the rat, Pharmacol. Biochem. Behav., 6:697.
Pirch, J.H., 1980, Event-related slow potentials in rat cortex during a reaction time task: Cortical area differences. Brain Res. Bull., 5:199.
Pirch, J.H., 1990, Basal forebrain neuron responses during right eye vs. left eye light discrimination, Soc. Neurosci. Abstr., In Press.
Pirch, J.H., and Barnes, P.R., 1972, Steady potential responses from the rat cortex during conditioning, Experientia, 28:164.
Pirch, J.H., Corbus, M.J., and Ebenezer, I., 1985a, Conditioned cortical slow potential responses in urethane anesthetized rats. Intern. J. Neuroscience., 25:207.
Pirch, J.H., Corbus, M.J., and Napier, T.C., 1981a, Auditory cue preceding intracranial stimulation induces event-related potential in rat frontal cortex: Alteration by amphetamine, Brain Res. Bull., 7:399.
Pirch, J.H., Corbus, M.J., and Rigdon, G.C., 1983, Single unit and slow potential responses from rat frontal cortex during associative conditioning, Exp. Neurol., 82:118.
Pirch, J.H., Corbus, M.J., and Rigdon, G.C., 1985b, Conditioning-related single unit activity in the frontal cortex of urethane anesthetized rats, Intern. J. Neuroscience, 25:263.
Pirch, J.H., Corbus, M.J., Rigdon, G.C., andLyness, W.H., 1986, Generation of cortical event-related slow potentials in the rat involves nucleus basalis cholinergic innervation, Electroencephalogr. Clin. Neurophysiol., 63:464.
Pirch, J.H., Napier, T.C., and Corbus, M.J., 1981b, Brain stimulation as a cue for event-related potentials in rat cortex: amphetamine effects. Intern. J. Neuroscience., 15:217.
Pirch, J.H., and Peterson, S.L., 1981, Event-related slow potentials and activity of single neurons in rat frontal cortex. Intern. J. Neuroscience, 15:141.
Pirch, J.H., Yadon, D., and Turco, K., 1989, Acetylcholine (ACh) role in conditioning-related responses of cortical neurons: Microiontophoretic studies, FASEB Journal., 3:A394.
Richardson, R.T., and Delong, M.R., 1986, Nucleus basalis of Meynert neuronal activity during a delayed response task in monkey, Brain Res., 399:364.
Richardson, R.T., and Delong, M.R., 1988, A reappraisal of the functions of the nucleus basalis of Meynert, TINS. 11:264.
Rigdon, G.C., and Pirch, J.H., 1984, Microinjection of procaine or GABA into nucleus basalis magnocellularis affects cue-elicited unit responses in the rat frontal cortex, Exp. Neurol., 85:283.
Rigdon, G.C., and Pirch, J.H., 1986, Nucleus basalis involvement in conditioned neuronal responses in the rat frontal cortex, J. Neurosci., 6:2535.
Rolls, E.T., Sanghera, M.K., and Roper-Hall, A., 1979, The latency of activation of neurones in the lateral hypothalamus and substantia innominata during feeding in the monkey. Brain Res., 164:121.
Rowland, V., Gluck, H., Sumergrad, S., and Dines, G., 1985, Slow and multiple unit potentials in trace and temporal conditioning controlled by electrical reward in the rat, Electroencephalogr. Clin. Neurophysiol., 61:559.
Rucker, H.K., Corbus, M.J., and Pirch, J.H., 1986, Discriminative conditioning-related slow potential and single-unit responses in the frontal cortex of urethane-anesthetized rat. Brain Res., 376:368.
Rye, D.B., Wainer, B.H., Mesulam, M.-M., Mufson, E.J., and Saper, C.B., 1984, Cortical projections arising from the basal forebrain: a study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase, Neuroscience. 13:627.
Semba, K., Reiner, P.B., McGeer, E.G., and Fibiger, H.C., 1988, Brainstem afferents to the magnocellular basal forebrain studied by axonal transport, immunohistochemistry, and electrophysiology in the rat, J. Comparative Neurol., 267:433.
Sillito, A.M., and Kemp, J.A., 1983, Cholinergic modulation of the functional organization of the cat visual cortex. Brain Res., 289:143.
Swartz, B.E., and Woody, C.D., 1979, Correlated effects of acetylcholine and cyclic guanosine monophosphate on membrane properties of mammalian neocortical neurons, J. Neurophysiol., 10:465.
Swartz, B.E., and Woody, C.D., 1984, Effects of intracellular antibodies to cGMP on responses of cortical neurons of awake cats to extracellular application of muscarinic agonists, Exp. Neurol., 86:388.
Travis, R.P.Jr., and Sparks, D.L., 1968, Unitary responses and discrimination learning in the squirrel monkey: the globus pallidus, Physiol. Behav., 3:187.
Turco, K., Yadon, D., and Pirch, J., 1988, Influence of microiontophoretic cholinergic drugs on conditioned cortical units, Soc. Neurosci. Abstr., 14:862.
Vives, F., and Mogenson, G.J., 1985, Electrophysiological evidence that the mediodorsal nucleus of the thalamus is a relay between the ventral pallidum and the medial prefrontal cortex in the rat, Brain Res., 344:329.
Watanabe, M., 1990, Prefrontal unit activity during associative learning in the monkey, Exp. Brain Res., 80:296.
Wenk, G.L., Markowska, A.L., and Olton, D.S., 1989, Basal forebrain lesions and memory: Alterations in neurotensin, not acetylcholine, may cause amnesia, Behav. Neurosci., 103:765.
West, C.H.K., and Michael, R.P., 1989, Responses of mesolimbic units to sensory input in rats conditioned by reinforcing brain stimulation, Soc. Neurosci. Abstr., 15:1012.
West, C.H.K., Schaefer, G.J., and Michael, R.P., 1990, Responses of single units in dopamine terminal areas to odors conditioned by reinforcing brain stimulation, FASEB Journal. 4:A978.
Wilson, D.A., and Sullivan, R.M., 1990, Olfactory associative conditioning in infant rats with brain stimulation as reward. I. Neurobehavioral consequences. Develop. Brain Res., 53:215.
Wilson, F.A.W., and Rolls, E.T., 1990a, Neuronal responses related to reinforcement in the primate basal forebrain. Brain Res., 509:213.
Wilson, F.A.W., and Rolls, E.T., 1990b, Learning and memory is reflected in the responses of reinforcement-related neurons in the primate basal forebrain, J. Neurosci., 10:1254.
Woody, C.D., 1982, Acquisition of conditioned facial reflexes in the cat: cortical control of different facial movements, Federation Proceedings. 41:2160.
Woody, C.D., Swartz, B.E., and Gruen, E., 1978, Effects of acetylcholine and cyclic GMP on input resistance of cortical neurons in awake cats, Brain Res., 158:373.
Woolf, N.J., and Butcher, L.L., 1986, Cholinergic systems in the rat brain: III. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain. Brain Res. Bull., 16:603.
Woolf, N.J., Hernit, M.C., and Butcher, L.L., 1986, Cholinergic and non-cholinergic projections from the rat basal forebrain revealed by combined choline acetyltransferase and Phaseolus vulgaris leucoagglutinin immunohistochemistry, Neurosci. Lett., 66:281.
Zaborszky, L., and Cullinan, W.E., 1989, Hypothalamic axons terminate on forebrain cholinergic neurons: an ultrastructural double-labeling study using PHA-L tracing and ChAT immunocytochemistry, Brain Res., 479:177.
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© 1991 Plenum Press, New York
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Pirch, J., Rigdon, G., Rucker, H., Turco, K. (1991). Basal Forebrain Modulation of Cortical Cell Activity During Conditioning. In: Napier, T.C., Kalivas, P.W., Hanin, I. (eds) The Basal Forebrain. Advances in Experimental Medicine and Biology, vol 295. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0145-6_11
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DOI: https://doi.org/10.1007/978-1-4757-0145-6_11
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