Skip to main content
SpringerLink
Log in

Photocarcinogenesis

  • Chapter
The Science of Photomedicine

Part of the book series: Photobiology ((PB))

Abstract

There has been a recent reawakening of interest in the field of photobiology. This has been largely due to rapid advances in photochemistry, particularly due to a much better understanding of photobiologic phenomena occurring on the molecular level, and a recent concern about potential alteration of the ozone layer. Furthermore, the great improvement in design, versatility, and intensity of modern light sources and the development of accurate measuring devices capable of determining the intensity of very narrow bands of light even in the ultraviolet (UV) region of the electromagnetic spectrum have made more elegant studies possible.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Charcot, P. (1858): Erythème produit par l’action de la lumière électriquè. C. R. Soc. Biol. (Paris) 5(Ser. 2):63–65.

    Google Scholar 

  2. Unna, P. (1894): Histopathologie der Hautkrankheiten. August Hirschwald, Berlin.

    Google Scholar 

  3. Hausser, K. W., and Vahle, W. (1927): Sonnenbrand und Sonnenbraunung. Wiss. Veroff. Siemens-Konzern 6:101–120.

    Google Scholar 

  4. Bloch, B. (1917): Das Problem der Pigmentbildung in der Haut. Arch. Dermatol. Syphilol (Berlin) 124:129–208.

    Google Scholar 

  5. Ehrman, S. (1905):Mracek’s Handbuch, Vol. 2, pp. 789. Vienna.

    Google Scholar 

  6. Hammer, F. (1891): Über den Einfluss des Lichtes. Ferdinand Enke, Stuttgart.

    Google Scholar 

  7. With, C. (1920): Studies on the effect of light on vitiligo. Br. J. Dermatol 32:145–155.

    Article  Google Scholar 

  8. Guillaume, A. C. (1926): Le pigment épidermique, la penetration des rayons ultraviolets et Ie mécanisme de protection de l’organisme vis-a-vis de ces radiations. Bull Soc. Med. Hop. (Paris) 42:1 133–1135.

    Google Scholar 

  9. Miescher, G. (1930): Das Problem der Lichtgewöhnung. Strahlentherapie 36:434.

    Google Scholar 

  10. Finsen, N. R. (1900): Neue Untersuchungen über die Einwirkung des Lichtes auf die Haut. Mit. Finsen Institut 1:8.

    Google Scholar 

  11. Dubreuilh, W. (1896): Des hyperkeratoses circonscriptes. Ann. Dermatol Syphiligr. (Paris) 7(Ser. 3): 1158–1204.

    Google Scholar 

  12. Shield, A. M.(1899): Aremarkablecaseof multiple growths of the skin caused by exposure to the sun. Lancet 1:22–23.

    Google Scholar 

  13. Hyde, J. (1906): On the influence of light in the production of cancer of the skin. Am. J. Med. Sci. 31:1–22.

    Article  Google Scholar 

  14. Paul, C. N. (1918):The Influence of Sunlight in the Production of Cancer of the Skin. H. K. Lewis, London.

    Google Scholar 

  15. Bruusgaard, cited in Rasch, C. (1926): Some historical and clinical remarks on the effect of light on the skin and skin diseases. Proc. R. Soc. Med. 20:11–20.

    PubMed  CAS  Google Scholar 

  16. Haxthausen, H., and Hausmann, W. (1929): Die Lichterkrankungen der Haut. Urban und Schwarzenberg, Vienna.

    Google Scholar 

  17. Findlay, G. M. (1928): Ultraviolet light and skin cancer. Lancet 2:1070–1073.

    Article  Google Scholar 

  18. Putschar, W., and Holtz, F. (1930): Erzeugung von Hautkrebsen bie Ratten durch langedaurende Ultraviolet Bestrahlung. Z. Krebsforsch. 33:219–260.

    Article  Google Scholar 

  19. Huldschinsky, K. (1933): Augensarkom bei Ratten hervorgerufen durch abnorm lange Ultraviolet Bestrahlung. Dtsch. Med. Wochenschr. 59:530–531.

    Article  Google Scholar 

  20. Roffo, A. H. (1933): Cancer y sol. Bol Inst. Med. Exp. Estud. Trata Cancer 10:417–439.

    Google Scholar 

  21. Roffo, A. H. (1934): Cancer et soleil. Carcinomes et sarcomes provoques par Faction du soleil in toto. Bull Cancer(Paris) 23:590–616. 1934.

    Google Scholar 

  22. Roffo, A. H. (1939): Über die physikalische Aetiologie der Krebskrankheit. Strahlentherapie 66:328–350.

    CAS  Google Scholar 

  23. Raab, O. (1899): Untersuchungen über die Wirkung fluoreszierender Stoffe. Z. Biol 38:16.

    Google Scholar 

  24. Tappeiner, H. V., and Jodlbauer, A. (1907): Die sensibilisierende Wirkung fluoreszierender Substanzen. Verlag FCW Vogel. Leipzig.

    Google Scholar 

  25. Jodlbauer, A. (1905): Die Beteilung des Sauerstoffes bei der Wirkung fluorescierenden Stoffe. Arch. Klin. Med. 82:520–546.

    Google Scholar 

  26. Busck, G., and Tappeiner, H. (1906): Über Lichtbehandlung blut-parasitârer Krankheiten. Arch. Klin. Med. 87:98–110.

    Google Scholar 

  27. Lewis, M. R. (1935): The photosensitivity of chick embryo cells growing in media containing certain carcinogenic substances. Am. J. Cancer 25:305–309.

    CAS  Google Scholar 

  28. Blum, H. F., Kirby-Smith, S., and Grady, H. G. (1941): Quantitative induction of tumors in mice with ultraviolet radiation. J. Natl. Cancer Inst. 2:259–268.

    Google Scholar 

  29. Blum, H. F. (1959): Carcinogenesis by Ultraviolet Light. Princeton Univ. Press, Princeton.

    Google Scholar 

  30. LeGrand, Y. (1970): Introduction to Photobiology. American Elsevier Press, New York.

    Google Scholar 

  31. Blum, H. F. (1950): On the mechanism of cancer induction by ultraviolet radiation. J. Natl Cancer Inst. 11:463–495.

    Google Scholar 

  32. Rogers, S. (1955): In vitro initiation of pulmonary adenomas in fetal mouse lung by single exposure ultraviolet irradiation of wavelength 2,537 Å. J. Natl Cancer Inst. 15:1001–1004.

    PubMed  CAS  Google Scholar 

  33. Epstein, J. H., and Roth, H. L. (1968): Experimental ultraviolet light carcinogenesis. J. Invest. Dermatol. 50:387–389.

    PubMed  CAS  Google Scholar 

  34. Pound, A. W. (1970): Induced cell proliferation and the initiation of skin tumor formation in mice by ultraviolet light. Pathology 2:269–273.

    Article  PubMed  CAS  Google Scholar 

  35. Hsu, T., Forbes, P. D., Harber, L. C., et al. (1975): Induction of skin tumors in hairless mice following single exposure to ultraviolet radiation. Photochem. Photobiol. 21:185–188.

    Article  PubMed  CAS  Google Scholar 

  36. Forbes, P. D., and Urbach, F. (1975): Experimental modification of photocarcinogenesis. III. Simulation of exposure to sunlight and fluroescent whitening agents. Food Cosmet. Toxicol. 131:343–345.

    Article  Google Scholar 

  37. Forbes, P. D. (1974): Influence of continued exposure to ultraviolet light (UVL) on UVL induced tumors. In: Abstracts of the 2nd Annual Meeting, American Society for Photobiology, Vancouver, 1974, p. 102.

    Google Scholar 

  38. Evans, R. G., and Norman, A. (1968): Unscheduled incorporation of thymidine in UV irradiated human lymphocytes. Radiat. Res. 36:287–298.

    Article  PubMed  CAS  Google Scholar 

  39. Epstein, J. H. Fukuyama, K., and Epstein, W. L. (1968): Ultraviolet light induced stimulation of DNA synthesis in hairless mouse epidermis. J. Invest. Dermatol. 51:445–453.

    PubMed  CAS  Google Scholar 

  40. Cleaver, J. E. (1968): Defective repair replication of DNA in xeroderma pigmentosum. Nature 218:652–656.

    Article  PubMed  CAS  Google Scholar 

  41. Cleaver, J. E., and Carter, P. M. (1973): Xeroderma pigmentosum: influence of temperature on DNA repair. J. Invest. Dermatol. 60:29–32.

    Article  PubMed  CAS  Google Scholar 

  42. Epstein, W. L., Fukuyama, K., and Epstein, J. H. (1971): Ultraviolet light, DNA repair and skin carcinogenesis in man. Fed. Proc. 30:1766–1771.

    PubMed  CAS  Google Scholar 

  43. Lieberman, M. W., and Forbes, P. D. (1973): Demonstrationof DN Arepairinnormaland neoplastic tissues after treatment with proximate chemical carcinogens and UV radiation. Nature [New Biol.] 241:199–201.

    CAS  Google Scholar 

  44. Norman, H., Ottoman, R. E., Chou, P., et al. (1972): Unscheduled DNA synthesis. Mutat. Res. 15:358–360.

    Article  PubMed  CAS  Google Scholar 

  45. Roberts, J. J. (1972): In: Molecular and Cellular Repair Processes, edited by R. F. Beers, R. F. Beers, R. M. Herriott, and R. Tilghman. Johns Hopkins Med. j. Suppl. 1:226–238.

    Google Scholar 

  46. Setlow, R. B., and Hart, R. W. (1974): Direct evidence that damaged DNA results in neoplastic transformation: a fish story. Radiat. Res. 59:73–74.

    Google Scholar 

  47. Zajdela, F., and Latarjet, R. (1973): The inhibiting effect of caffeine on the induction of skin cancer by ultraviolet light in the mouse. C. R. Acad. Sci. [D] (Paris) 277:1073–1076.

    CAS  Google Scholar 

  48. Hanawait, P. C., and Setlow, R. B. (Eds.) (1975): Molecular Mechanisms for Repair of DNA, Parts A and B. Plenum Press, New York/London.

    Google Scholar 

  49. Freeman, R. G., Hudson, H. T., and Carnes, R. (1970): Ultraviolet wavelength factor in solar radiation and skin cancer. Int. J. Dermatol. 9:232–235.

    Article  PubMed  CAS  Google Scholar 

  50. Freeman, R. G. (1975): Data on the action spectrum for ultraviolet carcinogenesis. J. Natl. Cancer Inst. 55:1119–1122.

    PubMed  CAS  Google Scholar 

  51. Freeman, R. G. (1978): Action spectrum for ultraviolet carcinogenesis. Natl. Cancer Inst. Monogr. 50:27–30.

    PubMed  Google Scholar 

  52. Wetzel, V. R. (1959): Zum Wirkungsspektrum der cancerogener Eigenschaften des ultravioletten Lichtes. Arch. Geschwulstforsch. 14:120–131; 15:227–237.

    PubMed  CAS  Google Scholar 

  53. Setlow, R. B. (1974): The wavelength in sunlight effective in producing skin cancer: a theoretical analysis. Proc. Natl. Acad. Sci. U.S.A. 71:3363–3366.

    Article  PubMed  CAS  Google Scholar 

  54. Forbes, P. D., Davies, R. E., and Urbach, F. (1978): Experimental ultraviolet carcinogenesis: wavelength interaction and time-dose relationships. Natl. Cancer Inst. Monogr. 50:31–38.

    PubMed  Google Scholar 

  55. Kripke, M. L., and Fisher, M. S. (1976): Immunologic parameters of ultraviolet carcinogenesis. J. Natl. Cancer Inst. 57:211–215.

    PubMed  CAS  Google Scholar 

  56. Kripke, M. L., and Fisher, M. S. (1978): Immunologic aspects of tumor induction by ultraviolet radiation. Natl. Cancer Inst. Monogr. 50:179–183.

    PubMed  Google Scholar 

  57. Fisher, M. S. (1978): A systemic effect of ultraviolet irradiation and its relationship to tumor immunity. Natl. Cancer Inst. Monogr. 50:185–188.

    PubMed  Google Scholar 

  58. Nathanson, R. B., Forbes, P. D., and Urbach, F. (1976): Modification of photocarcinogenesis by two immunosuppressive agents. Cancer Letters 1:243–247.

    Article  PubMed  CAS  Google Scholar 

  59. Lewin, L. (1913): Über photodynamische Wirkungen von Inhaltsstoffen des Steinkohlenteer Pech’s am Menschen. Munch. Med. Wochenschr. 60:1529–1530.

    CAS  Google Scholar 

  60. Fleischhauer, L. (1930): Über die sensibilisierende Wirkung des Teer präparates Liantral. Strahlentherapie 36:144–160.

    Google Scholar 

  61. Doniach, I., and Mottram, J. C. (1940): On the effect of light upon the incidence of tumors in painted mice. Am. J. Cancer 39:234–240.

    CAS  Google Scholar 

  62. Clark, J. H. (1964): The effect of longwave ultraviolet radiation on the development of tumors induced by 20-methylcholanthrene. Cancer Res. 24:207–211.

    PubMed  CAS  Google Scholar 

  63. Stenbäck, F. (1975): Studies on the modifying effect of ultraviolet radiation on chemical skin carcinogenesis. J. Invest. Dermatol. 64:253–257.

    Article  PubMed  Google Scholar 

  64. Morton, J. J., Luce-Clausen, E. M., and Mahoney, E. B. (1942): Visible light and skin tumors induced with benzpyrene in mice. Cancer Res. 2:256–260.

    CAS  Google Scholar 

  65. Kohn-Speyer, A. C. (1929): Effect on ultraviolet radiation on the incidence of tar cancer in mice. Lancet 1:1305–1306.

    Article  Google Scholar 

  66. Seelig, M. G., and Cooper, Z. K. (1933): Light and tar cancer. Surg. Gynecol. Obstet. 56:752–761.

    Google Scholar 

  67. Santamaria, L. (1960): Photodynamic action and carcinogenicity. In: Recent Contributions to Cancer Research in Italy, Vol. I, edited by P. Bucalossi and U. Veronesi, pp. 107. Rome.

    Google Scholar 

  68. Schonberg, A., Mustafa, A., Barakat, M. Z., et al. (1948): Photochemical reactions. XIII. (a) Photochemical reactions to ethylenes with phenanthraquinone and with 1,2,3-triketones. (b) Dimerisation reactions in sunlight. J. Chem. Soc. (London) 428:2126–2129.

    Google Scholar 

  69. Cook, J. H., and Martin, R. H.(1940): Polycyclic aromatic hydrocarbons. XXIV. J. Chem. Soc. (London) 1940(Part 2):1125–1127.

    Google Scholar 

  70. Davies, R. E., Dodge, H. A., and Austin, W. A. (1972): Carcinogenicity of DMBA under various light sources. In: Proceedings of the VIth International Congress of Photobiology, Bochum, 1972, Abstract 347.

    Google Scholar 

  71. Davies, R. E., Dodge, H. A., and DeShields, L. H. (1972): Alteration of the carcinogenic activity of DMBA by light (abstract). Proe. Am. Assoc. Cancer Res. 13:14.

    Google Scholar 

  72. Davies, R. E., and Dodge, H. A. (1973): Modification of chemical carcinogenesis by phototoxicity and photochemical decomposition of carcinogen. In: Proceedings of the 1st Annual Meeting of the American Society for Photobiology, Sarasota, 1972, p. 138.

    Google Scholar 

  73. Davies, R. E. (1978): Interaction of light on chemicals in carcinogenesis. Natl. Cancer Inst. Monogr. 50:45–50.

    PubMed  CAS  Google Scholar 

  74. Biingeler, W. (1937): Über den Einfluss photosensibilisierender Substanzen auf die Enstehungvon Hautgeschwülsten. Z. Krebsforsch. 46:130–167.

    Article  Google Scholar 

  75. Miescher, G. (1942): Experimentelle Untersuchungen über Krebserzeugung durch Photosensibilisierung. Schweiz. Med. Wochenschr. 23:1082–1084.

    Google Scholar 

  76. Heller, W. (1950): Experimentelle Untersuchungen über den Lichtkrebs. Strahlentherapie 81:529–548.

    PubMed  CAS  Google Scholar 

  77. Griffin, A. C., Hakim, R. E„ and Knox, J. (1958): The wavelength effect upon erythemal and carcinogenic response in psoralen treated mice. J. Invest. Dermatol. 31:289–295.

    PubMed  CAS  Google Scholar 

  78. Urbach, F. (1959): Modification of ultraviolet carcinogenesis by photoactive agents. J. Invest. Dermatol. 32:373–378.

    Article  PubMed  CAS  Google Scholar 

  79. Forbes, P. D., Davies, R. E., and Urbach, F. (1976): Phototoxicity and photocarcinogenesis: comparative effects of anthracene and 8-methoxypsoralen in the skin of mice. Food Cosmet. Toxicol. 14:303–306.

    Article  PubMed  CAS  Google Scholar 

  80. Fry, R. J. M., Ley, R. D., and Grube, D. D. (1978): Photosensitized reactions and carcinogenesis. Natl. Cancer Inst. Monogr. 50:39–43.

    PubMed  CAS  Google Scholar 

  81. Stenbäck, F. (1975): Ultraviolet light irradiation as initiating agent in skin tumor formation by the two-stage method. Eur. J. Cancer 11:241–246.

    PubMed  Google Scholar 

  82. Epstein, J. H. (1978): Photocarcinogenesis: a review. Natl. Cancer Inst. Monogr. 50:13–25.

    PubMed  Google Scholar 

  83. Forbes, P. D., Urbach, F., and Davies, R. E. (1979): Enhancement of experimental photocarcinogenesis by topical retinoic acid. Cancer Letters 7:85–90.

    Article  PubMed  CAS  Google Scholar 

  84. Pathak, M. A., Kramer, D. M., and Fitzpatric, T. B. (1974): Photobiology and photochemistry of furocoumarins (psoralens). In: Sunlight and Man: Normal and Abmormal Photobiologic Responses, edited by M. A. Pathak, L. C. Harber, M. Seiji, et al., pp. 335–368. Univ. of Tokyo Press, Tokyo.

    Google Scholar 

  85. Cole, R. S., and Sinden, R. R. (1975): Repair of crosslinked DNA in Escherichia coli. In: Molecular Mechanisms for Repair of DNA, edited by P. C. Hanawalt and R. B. Setlow, pp. 487–495. Plenum Press, New York.

    Chapter  Google Scholar 

  86. Blackburn, M. G., and Taussig, P. E. (1975): The photocarcinogenicity of anthracene: photochemical binding to deoxyribonucleic acid in tissue culture. Biochem. J. 149:289–291.

    PubMed  CAS  Google Scholar 

  87. Urbach, F., Rose, D. B., and Bonnern, M. (1972): Geneticand environmental interactions in skin carcinogenesis. In: Environment and Cancer (M. D. Anderson Hospital Conference Proceedings), pp. 356–371. Williams & Wilkins, Baltimore.

    Google Scholar 

  88. Urbach, F., Epstein, J. H., and Forbes, P. D. (1974): Ultraviolet carcinogenesis: experimental, global, and genetic aspects. In: Sunlight and Man: Normal and Abnormal Photobiologic Responses, edited by M. A. Pathak, L. C. Harber, M. Seiji, et al., pp. 259–283. Univ. of Tokyo Press, Tokyo.

    Google Scholar 

  89. Emmett, E. A. (1973): Ultraviolet radiation as a cause of skin tumors. CRC Crit. Rev. Toxicol. 2:211–255.

    Article  PubMed  CAS  Google Scholar 

  90. Dorn, H. F. (1944): Illness from cancer in the United States. Public Health Rep. 59:33, 65, 77.

    Google Scholar 

  91. Scotto, J., Kopf, A. W., and Urbach, F. (1974): Nonmelanoma skin cancer among Caucasians in four areas of the United States. Cancer 34:1333–1 138.

    Google Scholar 

  92. MacDonald, E. J., and Heinze, E. B. (1978): Epidemiology of Cancerin Texas. Raven Press, New York.

    Google Scholar 

  93. Haenszel, W., Marcus, S. C., and Zimmeren, E. G. (1956): Cancer morbidity in urban and rural areas. Public Health Service Publication #462. U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  94. Lynch, F. W., Seidman, H., and Hammond, E. C. (1970): Incidence of cutaneous cancer in Minnesota. Cancer 25:83–91.

    Article  PubMed  CAS  Google Scholar 

  95. Silverstone, H., and Gordon, D. (1966): Regional studies in skin cancer. Second report: Wet tropical and subtropical coast of Queensland. Med. J. Aust. 2:733–740.

    PubMed  CAS  Google Scholar 

  96. Gordon, D., Silverstone, H., and Smithhurst, B. A. (1972): The epidemiology of skin cancer in Australia. In: Melanoma and Skin Cancer, edited by W. H. McCarthy. New South Wales Government Printer, Sydney.

    Google Scholar 

  97. Magnus, K. (1977): Incidence of malignant melanoma of the skin in five Nordic countries. Int. J. Cancer 20:477–485.

    Article  PubMed  CAS  Google Scholar 

  98. Lee, J. A. H. (1973): The trend of mortality from primary malignant tumors of the skin. J. Invest. Dermatol. 59:445–448.

    Article  Google Scholar 

  99. National Academy of Sciences:Protection Aganist Depletion of Stratospheric Ozone by Chlorofluorocarbons, pp. 74–105. Washington, D.C.

    Google Scholar 

  100. Scotto, J., Fears, T. R., and Gori, G. A. (1975): Measurements of Ultraviolet Radiation in the United States and Comparison with Skin Cancer Data. U.S. Government Printing Office, Washington, D.C.

    Google Scholar 

  101. Berger, D., Robertson, D. F., and Davies, R. E. (1975): Field Measurementsof Biologically Effective UV Radiation. CIAP Monograph 5, Part I, Appendix D, pp. 2–233.

    Google Scholar 

  102. Cutchis, P. (1975): Estimates of increase in skin cancer incidence with time following a decrease in stratospheric ozone. In: CIAP Reports, Vol. 5, Appendix D to Chapter 7, pp. 7–141. National Technical Information Service, Springfield, Virginia.

    Google Scholar 

  103. Clemmeson, J. (1965): Statistical Studies of the Etiology of Malignant Neoplasms. Munksgaard, Copenhagen.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Skin and Cancer Hospital, Temple University School of Medicine, 19140, Philadelphia, Pennsylvania, USA

    F. Urbach

Authors
  1. F. Urbach
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    James D. Regan

  2. Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA

    John A. Parrish

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Plenum Press, New York

About this chapter

Cite this chapter

Urbach, F. (1982). Photocarcinogenesis. In: Regan, J.D., Parrish, J.A. (eds) The Science of Photomedicine. Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8312-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-8312-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8314-7

  • Online ISBN: 978-1-4684-8312-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation