Abstract
Some historians state that the disease rickets was reported to occur in humans as early as the second century A. D. (1, 2), but the disease was not considered a significant health problem until people began to congregate in the cities of Northern Europe during the Renaissance (1–4). In the mid-17th century, Whistler, DeBoot, and Glisson each independently recognized many of the major diagnostic signs of this disease and established rickets as a clinical entity. They noted that it was associated with deformities of the skeleton, particularly enlargement of the epiphyses at the joints of the long bones and the rib cage (rachitic rosary), enlargement of the head, bending of the spine, curvature of the thighs, and flabby and toneless legs that were usually unable to sustain the weight of the body (1, 3, 4). The incidence of this debilitating bone disease increased dramatically during the industrial revolution, especially in Northern Europe and North America, and, by the latter part of the 19th century, autopsy studies suggested that approximately 90% of the children raised in the crowded cities of these areas had the disease.
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References
Mettler, C. C. (1947): History of Medicine, pp. 720–723. Blakiston, Philadelphia.
Foote, J. A. (1927): Evidence of rickets prior to 1650. Am. J. Dis. Child. 34:443–452.
Griffenhagen, G. (1952): A brief history of nutritional diseases. II. Rickets. Bull. Natl. Inst. Nutr. 2(9):1–2.
Guthrie, D. (1946): In: A History of Medicine, p. 69. Lippincott, Philadelphia.
Sniadecki, J. (1840). [Cited by W. Mozolowski: Jedrzej Sniadecki (1768–1883) on the cure of rickets. Nature 143:121 (1939).]
Owen, I. (1889): Geographical distribution of rickets, acute and subacute rheumatism, chorea, cancer and urinary calculus in the British Islands. Br. Med. J. 1:113–116.
Palm, T. A. (1890): The geographic distribution and etiology of rickets. Practitioner 45:270–279, 321–342.
Park, E. A. (1923): The etiology of rickets. Physiol. Rev. 3:106–159.
Huldschinsky, K. (1919): Heilungvon Rachitis durch künstliche Höhensonne. Detsch. Med. Wochenschr. 14:712–713.
Hess A. F., and Unger, L. J. (1921): Cure of infantile rickets by sunlight. J. A.M.A. 77:39.
Mellanby, E. (1918): The part played by an “accessory factor” in the production of experimental rickets. J. Physiol. 52:11–14.
Mellanby, E. (1919): An experimental investigation on rickets. Lancet 1:407–412.
McCollum, E. V., Simmonds, N., Shipley, P. G., et al. (1921): Studies on experimental rickets. The production of rickets by diets low in phosphorus and fat-soluble A. J. Biol. Chem. 47:507–527.
McCollum, E. V., Simmonds, N., Becker, J. E., et al. (1922): Studies on experimental rickets. An experimental demonstration of the existence of a vitamin which promotes calcium deposition. J. Biol. Chem. 53:293–312.
Hopkins, F. G. (1920): The effects of heat and aeration upon the fat-soluble vitamin. Biochem. J. 14:725–730.
Powers, G. F., Park, E. A., Shipley, P. G., et al. (1921): The prevention of rickets in the rat by means of radiation with the mercury vapor quartz lamp. Proc. Soc. Exp. Biol. Med. 19:120–121.
Goldblatt, H., and Soames, K. M. (1923): Studies on the fat soluble growth-promoting factor. Biochem. J. 17:446–453.
Steenbock, H. (1924): The induction of growth promoting and calcifying properties in a ration exposed to light. Science 60:224–225.
Steenbock, H., and Black, A. (1924): The reduction of growth-promoting and calcifying properties in a ration by exposure to ultraviolet light. J. Biol. Chem. 61:408–422.
Hess, A. F., Weinstock, M. (1924): Antirachitic properties imparted to inert fluids and green vegetables by ultraviolet irradiation. J. Biol. Chem. 62:301–313.
Hess, A. F., Weinstock, M., and Helman, D. F. (1925): The antirachitic value of irradiated phytosterol and cholesterol. J. Biol. Chem. 63:305–308.
Rosenheim, O., and Webster, T. A. (1926): The anti-rachitic properties of irradiated sterols. Biochem. J. 20:537–544.
Rosenheim, O., and Webster, T. A. (1927): On the nature of the parent substance of vitamin D. Lancet 1:306–307.
Reerink, E. H., and van Wijk, A. (1929): The photochemical reactions of ergosterol. Biochem. J. 23:1294–1307.
Askew, F. A., Bourdillon, R. B., Bruce, H. M., et al. (1931): The distillation of vitamin D. Proc. R. Soc. Lond. [Biol.] 107:76–90.
Fieser, L. D., and Fieser, M. (1959): Vitamin D. In: Steroids, pp. 90–168. Reinhold, New York.
Crawfoot, D., and Dunitz, J. D. (1948): Structure of calciferol. Nature 162:608–610.
Windaus, A., Lüttringhaus, A., and Deppe, M. (1931): Uberdas krystallisierte Vitamin D. Justus Liehig’s Ann. Chem. 489:252–269.
Windaus, A., Linsert, O., Lüttringhaus, A., et al. (1932): Über das krystallisierte Vitamin D2. Justus Liebig’s Ann. Chem. 492:226–241.
Massengale, O. N., and Nussmeier, M. (1930): The action of activated ergosterol in the chicken. J. Biol. Chem. 87:423–425.
Steenbock, H., and Kletzien, S. W. F. (1932): The reaction of the chicken to irradiated ergosterol and irradiated yeast as contrasted with the natural vitamin D in fish liver oil. J. Biol. Chem. 97:249–264.
Waddell, J. (1934): The provitamin D of cholesterol. I. The antirachitic efficacy of irradiated cholesterol. J. Biol. Chem. 105:711–739.
Windaus, A., Schenck, Fr., and von Werder, F. (1936): Über das antirachitisch wirksame Bestrahlungsprodukt aus 7-dehydrocholesterin. Z Physiol. 241:100–103.
Brockmann, H. (1936): Die Isolierung des antirachitischen Vitamins aus Tunfischleberol. Hoppe Seylers Z. Physiol. Chem. 241:104–113.
Velluz, L., Amiard, G., and Petit, A. (1949): Le precalciferol—ses relations d’équilibre avec Ie calciferol. Bull. Soc. Chim. Fr. 16:501–508.
Schlatmann, J. L. M., Pot, J., and Havinga, E. (1964): An investigation into the interconversion of precalciferol and calciferol and analogous compounds. Reel. Trav. Chim. Pays-Bas 83:1173–1184.
Havinga, E. (1973): Vitamin D, example and challenge. Experientia 29:1181–1193.
Jacobs, H. J. C., Boamsma, F., Havinga, E., et al. (1977): The photochemistry of previtamin Dand tachysterol. Reel. Trav. Chim. Pays-Bas Belg. 96:113–117.
Hess, A., Pappenheimer, A. M., and Weinstock, M. (1922): A study of light waves in relation to their protective action in rickets. Proc. Soc. Exp. Biol. Med. 20:14–16.
Kon, S. K., Daniels, F., and Steenbock, H. (1928): The quantitative study of the photochemical activation of sterols in the cure of rickets. J. Am. Chem. Soc. 50:2573–2581.
Bunker, J. W. M., and Harris, R. S. (1937): Precise evaluation of ultraviolet therapy in experimental rickets. N. Engl. J. Med. 216:165–169.
Knudson, A., and Benford, F. (1938): Quantitative studies of the effectiveness of ultraviolet radiation of various wavelengths on rickets. J. Biol. Chem. 124:287–299.
Bunker, J. W. M., Harris, R. S., and Mosher, M. L. (1940): Relative efficiency of active wavelengths of ultraviolet light in activation of 7-dehydrocholesterol. J. Am. Chem. Soc. 62:508–511.
Kobayashi, T., and Yasumura, M. (1973): Studies on the ultraviolet irradiation of provitamin D and its related compounds. Effect of wavelength on the formation of potential vitamin D2 in the irradiation of ergosterol by monochromatic ultraviolet rays. J. Nutr. Sci. Vitaminol. (Tokyo) 19:123–128.
Ziffer, H., Vanden Heuvel, W. J. A., Haahti, E. O. A., et al. (1960): Gas chromatographic behavior of vitamin D2 and D3. J. Am. Chem. Soc. 82:6411–6415.
Holick, M. F., Holick, S. A., McNeill, S. C., et al. (1979): The photobiochemistry of vitamin D3 in vivo in the skin. In:Vitamin D: Basic Research and Its Clinical Application (Proceedings of the Fourth Workshop on Vitamin D, Berlin, West Germany, February 1979), edited by A. W. Norman, K. Schaefer, D. v. Herrath, et al. pp. 173–176. Walter de Gruyter, Berlin/New York.
Holick, M. F., McNeill, S. C., MacLaughlin, J. A., et al. (1979): The physiologic implications of the formation of previtamin D3 in skin. Trans. Assoc. Am. Physicians XCII:54–63.
Hess, A. F. (1925): The antirachitic activation of foods and of cholesterol by ultraviolet radiation. J. Am. Med. Soc. 84:1910–1913.
Hou, H. (1931): Relation of preen gland of birds to rickets III. Site of activation during irradiation. Chin. J. Physiol. 5:11–18.
Reinertson, R. P., and Wheatly, V. R. (1959): Studiesonthechemicalcompositionofhuman epidermal lipids. J. Invest. Dermatol. 32:49–59.
Rauschkolb, E. W., Winston, D. Fenimore, D. C., Black, H. S., and Fabre, L. F. (1969): Identification of vitamin D3 in human skin. J. Invest. Dermatol. 53:289–293.
Okano, T., Yasumura, M., Mizuno, K., and Kobayashi, T. (1977): Photochemical conversion of 7-dehydrocholesterol into vitamin D3 in rat skins. J. Nutr. Sci. Vitaminol. (Tokyo) 23:165–168.
Esvelt, R. P., Schnoes, H. K., and DeLuca, H. F. (1978): Vitamin D3 from rat skins irradiated in vitro with ultraviolet light. Arch. Biochem. Biophys. 188:282–286.
Petrova, E. A., Nikulicheva, S. I., and Lazareva, N. P. (1976): Obrazovanie prekholekal’-tsiferola in vivo. Vopr. Pitan., 5:50–52.
Holick, M. F., Frommer, J., McNeill, S., Richtand, N., Henley, J., and Potts, J. T., Jr. (1977): Conversion of 7-dehydrocholesterol to vitamin D3 in vivo: Isolation and identification of previtamin D3 from skin. In: Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism (Proceedings of the Third Workshop on Vitamin D, Asilomar, California, January 1977), edited by A. W. Norman, K. Schaefer, J. W. Coburn, H. F. DeLuca, D. Fraser, H. G. Grigoleit, and D. v. Herrath, pp. 135–137. Walter de Gruyter, Berlin/New York.
Holick, M. F., Frommer, J. E., McNeill, S. C., Richtand, N. M., Henley, J. F., and Potts, J. T., Jr. (1977): Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin. Biochem. Biophys. Res. Commun. 76:107–114.
Holick, M. F., Richtand, N. M., McNeill, S. C., Holick, S. A., Frommer, J. E., Henley, J. W., and Potts, J. T., Jr. (1979): Isolation and identification of previtamin D3 from the skin of rats exposed to ultraviolet irradiation. Biochemistry 18:1003–1008.
Holick, M. F., McNeill, S. C., MacLaughlin, J., Clark, M. B., Holick, S. A., and Potts, J. T., Jr. (1979): The epidermis: A unique organ responsible for the photo-biosynthesis of vitamin D3. In: Endrocrinology ‘79, pp. 301–307, Elsevier/North-Holland Biomedical Press, Amsterdam.
Elias, P.M., Fritsch, P., and Epstein, E. H. (1977): Staphylococcal scalded-skin syndrome. Clinical features, pathogenesis, and recent microbiological and biochemical developments. Arch. Dermatol. 113:207–211.
Scheuplein, R. J. (1965): Mechanism of percutaneous absorption. Routes of penetration and the influence of solubility. J. Invest. Dermatol. 45:334–346.
Holick, M. F., and Potts, J. T., Jr. (1980): Vitamin D. In: Harrison’s Princples of Internal Medicine, 9th ed., edited by K. J. Isselbacher, R. D. Adams, E. Braunwald, R. G. Petersdorf, and J. D. Wilson, pp. 1843–1849. McGraw-Hill, New York.
Haussler, M. R., and McCain, T. A. (1977): Basic and clincal concepts related to vitamin D metabolism and action. N. Engl. J. Med. 297:974–983, 1041–1050.
DeLuca, H. F., and Schnoes, H. K. (1976): Metabolism and mechanism of action of vitamin D. Annu. Rev. Biochem. 45:631–642.
Norman, A. W., and Henry, H. (1974): 1,25-Dihydroxycholecalciferol—a hormonally active form of vitamin D3. Recent Prog. Horm. Res. 30:431–480.
Hess, A. F., and Lundagen, M. A. (1922): A seasonal tide of blood phosphate in infants. J. AMA 79:2210–2212.
Bekemeier, H., and Pfennigsdorf, G. (1959): VersuchezurerschopfandenUV-Aktiverungdes Provitamin D in Schweineschwarte. Hoppe Seylers Z. Physiol. Chem. 314:120–124.
Preece, M. A., Tomlinson, S., Ribot, C. A., Pietrek, J., Korn, H. T., Davies, D. M., Ford, J. A., Dunnigan, M. G., and O’Riordan, J. L. H.(1975): Studies of vitamin Ddeficiencyin man. Q. J. Med. 44:575–589.
Fairney, A., Fry, J., and Lipscomb, A. (1979): The effect of darkness on vitamin D in adults. Postgrad. Med. J. 55:248–250.
Haddad, J. G. and Chyu, K. J. (1971): Competitive protein binding radioassay for 25-hydroxycholecalciferol. J. Clin. Endocrinol. Metab. 33:992–996.
Neer, R., Clark, M., Friedman, V., Belsey, R., Sweeney, M., Buonchristiani, J., and Potts, J., Jr. (1977): Environmental and nutritional influences on plasma 25-hydroxyvitamin D concentration and calcium metabolism in man. In: Vitamin D: Biochemical, Chemical and Clinical Aspects Related to Calcium Metabolism (Proceedings of the Third Workshop on Vitamin D), edited by A. W. Norman, K. Schaefer, J. W. Coburn, H. F. DeLuca, D. Fraser, H. G. Grigoleit, and D. v. Herrath, pp. 595–606. Walter de Gruyter, Berlin/New York.
Hess, A. F. (1922): New aspects of the rickets problem. J. A.M.A. 78:1177–1183.
Kramer, B., Casparis, H., and Howland, J. (1923): Ultraviolet radiation in rickets: Effect on the calcium and inorganic phosphorus concentration of the serum. Am. J. Dis. Child. 24:20–26.
Levinsohn, S. (1927): Rickets in the Negro: Effect of treatment with ultraviolet rays. Am. J. Dis. Child. 34:955–966.
Loomis, F. (1967): Skin-pigment regulation of vitamin D biosynthesis in man. Science 157:501–506.
Beadle, P. C. (1977): The epidermal biosynthesis of cholecalciferol (vitamin D3). Photochem. Photobiol. 25:519–527.
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© 1982 Plenum Press, New York
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Holick, M.F., MacLaughlin, J.A., Parrish, J.A., Anderson, R.R. (1982). The Photochemistry and Photobiology of Vitamin D3 . In: Regan, J.D., Parrish, J.A. (eds) The Science of Photomedicine. Photobiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8312-3_7
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DOI: https://doi.org/10.1007/978-1-4684-8312-3_7
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