Abstract
The thromboxane A2/prostaglandin H2 (TXA2/PGH2) mimetic, U-46619, is a potent platelet aggregating agent and constrictor of vascular smooth muscle. Aggregation and contraction to U-46619, and other TXA2/PGH2 mimetics, such as U-44069 and carbocyclic TXA2, are associated with both an influx of extracellular Ca2+ and a release of Ca2+ from binding and sequestration sites within the platelet and arterial smooth muscle (Greenberg, 1981; Loutzenhiser and van Breemen, 1981; Dorn et al., 1987; Santoian et al., 1987). These mechanisms were shown by the ability of both calcium channel blocking agents and intracellular calcium antagonists, such as dantrolene sodium and TMB-8, to inhibit contraction of vascular smooth muscle to TXA2/PGH2 receptor mimetics and by the ability of these mimetics to increase 45Ca efflux without affecting 45Ca uptake (Ally et al., 1978; Greenberg, 1981; Loutzenhiser and Van Breemen, 1981; Angerio et al., 1982; Dorn et al., 1987; Santoian et al., 1987). The pool of Ca2+ utilized for the physiologic and pharmacologic actions of U-46619 appears to depend on the site and species from which the arteries and platelets are obtained (Greenberg, 1981; Loutzenhiser and Van Breemen, 1981; Angerio et al., 1982; Dorn et al, 1987; Santoian et al., 1987; Verheyen et al., 1989).
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© 1991 Plenum Press, New York
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Greenberg, S.S. et al. (1991). Calcium-Dependent and Independent Mechanisms of Contraction in Canine Lingual Artery to U-46619. In: Moreland, R.S. (eds) Regulation of Smooth Muscle Contraction. Advances in Experimental Medicine and Biology, vol 304. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6003-2_42
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DOI: https://doi.org/10.1007/978-1-4684-6003-2_42
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