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Pharmacomechanical Coupling: The Membranes Talk to the Crossbridges

  • Chapter
Regulation of Smooth Muscle Contraction

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 304))

Abstract

Excitation-contraction (E-C) coupling in smooth muscle (Table 1) is distinguished by the importance of pharmacomechanical coupling: a complex of signal transduction mechanisms that is not directly dependent on changes in membrane potential (Somlyo and Somlyo, 1968). In contrast, in striated muscle electromechanical coupling is the dominant E-C coupling mechanism. We shall emphasize pharmacomechanical coupling in this overview, not only because of its importance and our interest in it, but also because there has been major progress in our understanding of its molecular mechanisms, particularly the mechanisms of Ca2+ release and modulation of Ca2+-sensitivity.

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Authors and Affiliations

  1. Department of Physiology, University of Virginia School of Medicine, Charlottesville, VA, 22908, USA

    Andrew P. Somlyo, Toshio Kitazawa, Sei Kobayashi, Ming Cui Gong & Avril V. Somlyo

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  1. Andrew P. Somlyo
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  2. Toshio Kitazawa
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  3. Sei Kobayashi
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  4. Ming Cui Gong
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  5. Avril V. Somlyo
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Editors and Affiliations

  1. Bockus Research Institute, The Graduate Hospital, USA

    Robert S. Moreland

  2. The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA

    Robert S. Moreland

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© 1991 Plenum Press, New York

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Somlyo, A.P., Kitazawa, T., Kobayashi, S., Gong, M.C., Somlyo, A.V. (1991). Pharmacomechanical Coupling: The Membranes Talk to the Crossbridges. In: Moreland, R.S. (eds) Regulation of Smooth Muscle Contraction. Advances in Experimental Medicine and Biology, vol 304. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-6003-2_17

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  • DOI: https://doi.org/10.1007/978-1-4684-6003-2_17

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