Abstract
Myogenesis is an important aspect of developmental biology that has been actively investigated in cultured cells for nearly three decades. Interest has been heightened and activity more sharply focussed during the past few years by the discovery of a family of myogenesis controlling genes, which appear to play major roles in the aspect of myogenesis to be considered here: the terminal differentiation of proliferating myoblasts to form postmitotic myotubes in which a number of muscle-specific genes are expressed. Most attention on the control of this process has been concentrated on its negative regulation by medium components initially characterized loosely as „mitogens,“ but subsequently identified as Fibroblast Growth Factor (FGF) and Transforming Growth Factor-beta (TGF-ft). This laboratory has shown that the Insulinlike Growth Factors (IGFs), in contrast, are stimulators of myogenesis, and recent work suggests that autocrine/paracrine actions of the IGFs may play an important role in differentiation in low serum medium even when the exogenous growth factors are not added. Thus, initiation of myogenic differentiation in vitro requires not only the removal of inhibitors present in serum, but also the secretion or addition of stimulators of this process.
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References
Adashi, E. Y., Resnick, C. E., Dercole, A. J., Svoboda, M. E., and Van Wyk, J. J., 1985, Insulin-like growth factors as in-traovarian regulators of granulosa cell growth and function, Endocr. Rev., 6:400.
Allen, R. E., and Boxhorn, L. K., 1989, Regulation of skeletal muscle satellite cell proliferation and differentiation by transforming growth factor-beta, insulin-like growth factor-I, and fibroblast growth factor, J. Cell. Physiol., 138:311.
Ball, E. H., and Sanwall, B. D., 1980, A synergistic effect of glucocorticoids and insulin on the differentiation of myoblasts, J. Cell. Physiol., 102:27.
Ballard, F. J., Read, L. C., Francis, G. L., Bagley, C. J., and Wallace, J. C., 1986, Binding properties and biological potencies of insulin-like growth factors in L6 myoblasts, Biochem. J., 233:223.
Ballard, F. J., Ross, M., Upton, F. M., and Francis, G. L., 1988, Specific binding of insulin-like growth factors 1 and 2 to the type 1 and type 2 receptors respectively, Biochem. J., 249:721.
Bassas, L., de Pablo, F., Lesniak, M., A., and Roth, J., 1987, The insulin receptors of chick embryo show tissue-specific structural differences which parallel those of the insulinlike growth factor I receptors, Endocrinology., 121:1468.
Baxter, R. C., 1988, The insulin-like growth factors and their binding proteins, Comp. Biochem. Physiol., 91B:229.
Baxter, R. C., and Martin, J. L., 1989, Binding proteins for the insulin-like growth factors: structure, regulation and function, Progr. Growth. Factor. Res., 1:49.
Beck, F., Samani, N. J., Byrne, S., Morgan, K., Gebhard, R., Brammar, W. J., 1988, Histochemical localization of IGF-I and IGF-II mRNA in the rat between birth and adulthood, Development., 104:29.
Beguinot, F., Kahn, C. R., Moses, A. C., and Smith, R. J., 1985, Distinct biologically active receptors for insulin, insulin-like growth factor I, and insulin-like growth factor II in cultured skeletal muscle cells, J. Biol. Chern., 260:1589 .
Beguinot, F., Kahn, C. R., Moses, A. C., and Smith, R. J., 1986, The development of insulin receptors and responsiveness is an early marker of differentiation in the muscle cell line L6, Endocrinol., 18:446.
Beguinot, F., Formisano, P., Condorelli, G., Tramontano, D., Villone, G., Liquoro, D., Consiglio, E., and Aloj, S. M., 1988, The endogenous substrate for the IGF-I receptor kinase ppl75 in the FRTL-5 cell is a cytoskeleton-associated protein, Program, and. Abstracts,, the. Endocrine. Society., 1988: .
Braun, T., Bober, E., Buschhausen-Denker, G. Kotz, S., Grzeschik, K.-H., and Arnold, H. H., 1989a, Differential expression of myogenic determination genes in muscle cells: possible autoactivation by the myf gene products, EMBO. J., 8:3617.
Braun, T., Buschhausen-Denker, G., Bober, E., Tannich, E., and Arnold, H. H., 1989b, A novel human muscle factor related to but distinct from myoDl induces myogenic conversion in 10T1/2 fibroblasts, EMBO. J., 8:701.
Braun, T., Bober, E., Winter, B., Rosenthal, N.,and Arnold, H. H., 1990, Myf-6, a new member of the human gene family of myogenic determination factors: evidence for a gene cluster on chromosome 12, EMBO. J., 9:821.
Brennan, T. J., and Olson, E. N., 1990a, Myogenin resides in the nucleus and acquires high affinity for a conserved enhancer element on heterodimerization, Genes. & Develop., 4:582.
Brennan, T. J., Edmondton, D. G., and Olson, E. N., 1990, Aberrant regulation of MyoDl contributes to the potentailly defective myogenic phenotype of BC3HI cells, J Cell. Biol. 110:929.
Burgering, B. M. T., Snijders, A. J., Maassen, J. A., van der Eb, A. J., and Bos, J. L., 1989, Possible involvement of normal p21 h-ras in the insulin/Insulinlike growth factor 1 signal transduction pathway, Mol. Cell. Biol., 9:4312.
Davis, R. L., Weintraub, H., and Lassar, A. B., 1987, Expression of a single transfected cDNA converts fibroblasts to myoblasts, Cell., 51:987.
Davis, R. L., Cheng, P.-F., Lassar, A. B., and Weintraub, H., 1990, The myoD DNA binding domain contains a recognition code for muscle-specific gene activation, Cell., 60:733.
de la Haba, G., Cooper, G. W., and Elting, V., 1966, Hormonal requirements for myogenesis in vitro: insulin and somatotropin, Proc. Nat. Acad. Sci. USA., 56:1719.
DeVol, D. L., Rotwein, P., Sadow, J. L., Novakofski, J., and Bechtel, P. J., 1990, Activation of insulin-like growth factor gene expression during work-induced skeletal muscle growth, Am. J. Physiol. (Endocrinol. Metab)., 259:E89.
De Vroede, M. A., Romanus, J. A., Standaert, M. L., Pollett, R. J., Nissley, S. P., Rechler, M. M. 1984. Interaction of insulin-like growth factors with a nonfusing mouse muscle cell line: binding, action, and receptor down-regulation. Endocrinol. 114:1917–192 9
Dodson, M. V., Allen, R. E., and Hossner, K. L., 1985, Ovine somatomedin, multiplication-stimulating activity, and insulin promote skeletal muscle satellite cell proliferation in vitro, Endocrinol., 117:2357.
Edmondson, D. G., and Olson, E. N., 1989, A gene with homology to the myc similarity region of myoDl is expressed during myogenesis and is sufficient to activate the muscle differentiation program, Genes. & Develop., 3:628.
Edwall, D., Schalling, M., Jennische, E., and Norstedt, G., 1989, Induction of insulin-like growth factor I messenger ribonucleic acid during regeneration of rat skeletal muscle, Endocrinol., 124: 820.
Elgin, R. G., Busby, W. H., Jr., and Clemmons, D. R., 1987, An insulin-like growth factor (IGF) binding protein enhances the biological response to IGF-I, Proc. Natl. Acad. Sci., 84:3254.
Endo, T., and Nadal-Ginard, B., 1986, Transcriptional and post-transcriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype, Mol. Cell. Biol., 6:1412.
Ewton, D. Z., and Florini, J. R., 1981, Effect of somatomedins and insulin on myoblast differentiation in vitro, Develop. Biol., 86:31.
Ewton, D. Z., Erwin, B. G., Pegg, A. E., and Florini, J. R., 1984, The role of polyamines in somatomedin-stimulated differentiation of L6 myoblasts, J. Cell. Physiol., 120:263.
Ewton, D. Z., Falen, S. L., and Florini, J. R., 1987, The type II IGF receptor has low affinity for IGF-I analogs: pleio-typic actions of IGFs on myoblasts are apparently mediated by the type I receptor, Endocrinology., 120:115.
Ewton, D. Z., Spizz, G., Olson, E. N., and Florini, J. R., 1988, Decrease in transforming growth factor-fl binding and action during differentiation in muscle cells, J. Biol. Chem., 263:4029.
Florini, J. R., 1987, Hormonal control of muscle growth, Muscle. & Nerve., 7:577.
Florini, J. R., and Ewton, D. Z., 1981, Insulin acts as a somatomedin analog in stimulating myoblast growth in serum-free medium, In. Vitro., 17:763.
Florini, J. R., and Ewton, D. Z., 1990, Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA; no effects on other actions of IGF-I, J. Biol. Chem., Sub:.
Florini, J. R., Ewton, D. Z., Evinger-Hodges, M. J., Falen, S. L., Lau, R.L., Regan, J. F., and Vertel, B. M., 1984, Stimulation and inhibition of myoblast differentiation by hormones, In. Vitro., 20:942.
Florini, J. R., Ewton, D. Z., Falen, S. L., and Van Wyk, J. J., 1986, Biphasic concentration dependency of the stimulation of myoblast differentiation by somatomedins, Am. J. Physiol. (Cell. Physiol)., 250:771.
Florini, J. R., and Magri, K. A., 1989, Effects of growth factors on myogenic differentiation, Am. J. Physiol. (Cell. Physiol. 25)., 256:C701.
Florini, J. R., Roberts, A. B., Ewton, D. Z., Falen, S. B., Flanders, K. C., and Sporn, M. B., 1986, Transforming growth factor-fi. A very potent inhibitor of myoblast differentiation, identical to the differentiation inhibitor secreted by buffalo rat liver cells, J. Biol. Chem., 261:16509.
Gospodarowicz, D., Ferrara, N., Schweigerer, L., and Neufeld, G., 1987, Structural characterization and biological functions of fibroblast growth factor, Endocrine. Rev., 8:95.
Gossett, L. A., Zhang, W., and Olson, E. N., 1988, Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes, J. Cell. Biol., 106:2127.
Gulve, E. A., and Dice, J. F., 1989, Regulation of protein synthesis and degradation in L8 myotubes. effects of serum, insulin, and insulin-like growth factors, Biochem. J., 260:377.
Han, V. K., Hill, D. J., Strain, A. J., Towle, A. C., Lauder, J. M., Underwood, L. E., and Dercole, A. J., 1987, Identification of somatomedin/Insulin-like growth factor im-munoreactive cells in the human fetus, Pediatr. Res., 22:245.
Han, V. K., Lund, P. K., Lee, D. C., Dercole, A. J., 1988, Expression fo somatomedin/insulin-like growth factor messenger ribonucleic acids in the human fetus: identification characterization, and tissue distribution, J. Clin. Endocrinol. Metab., 66:422.
Harper, J. M., Soar, J. B., Buttery, P. J., 1987, Changes in protein metabolism of ovine primary muscle cultures on treatment with growth hormone, insulin, insulin-like growth factor I or epidermal growth factor, J. Endocrinol., 112:87.
Heino, J., and Massague, J., 1990, Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor ft, J. Biol. Chem., 265:10181.
Hickey, R., Skoultchi, A., Gunning, P., and Kedes, L., 1986, Regulation of a human cardiac actin gene introduced into rat L6 myoblasts suggests a defect in their myogenic program, Mol. Cell. Biol., 6:3287.
Hill, D. J., Crace, C. J., Strain, A. J., and Milner, R. D. G., 1986, Regulation of amino acid uptake and deoxyribonucleic acid synthesis in isolated human fetal fibroblasts and myoblasts: effect of human placental lactogen, somatomedin-C., multiplication-J. Clin. End. Metab., 62:753.
Hill, D. J., Clemmons, D. R., Wilson, S., Han, V. K., Strain, A. J., and Milner, R. D., 1989, Immunological distribution of one form of insulin-like growth factor (IGF)-binding protein and IGF peptides in human fetal tissues, J. Mol. Endocrinol., 2:31.
Hu, J. S., and Olson, E. N. during Terminal Differentiation, 1990, Functional receptors for transforming growth factor-B are retained by biochemically differentiated C2 myocytes in growth factor deficient medium containing EGTA, but down-regulated, J. Biol. Chem., 265:7914.
Isgaard, J., Nilsson, A., Vikman, K., Isaksson, O. G., 1989, Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle, J. Endocrinol., 120:107.
Ishi, D. N., 1989, Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis, Proc. Natl. Acad. Sci. USA., 86:2898.
Janeczko, R. A., and Etlinger, J. D., 1984, Inhibition of intracellular proteolysis in muscle cultures by multiplication stimulating activity (MSA): comparison of effects of MSA and insulin on proteolysis, protein synthesis, amino, J. Biol. Chem., 259:6292.
Jennische, E., and Hansson, H.-A., 1987, Regenerating skeletal muscle cells express insulin-like growth factor I, Acta. Physiol. Scand., 130:327.
Jennische, E., and Olivecrona, H., 1987, Transient expression of insulin-like growth factor I immunoreactivity in skeletal muscle cells during postnatal development in the rat, Acta. Physiol. Scand., 131:619.
Jennische, E., Skottner, A., and Hansson, H.A., 1987, Satellite cells express the trophic factor IGF-I in regenerating skeletal muscle, Acta. Physiol. Scand., 129:9.
Jennische, E., Skottner, A., and Hansson, H.A., 1987, Dynamic changes in isulin-like growth factor I immunoreactivity correlate to repair events in rat ear after freeze-thaw injury, Exper. Mol. Pathol., 47:193.
Kiess, W., Haskell, J. F., Greenstein, L. A., Miller, B. E., Aarons, A. L., Rechler, M. M., and Nissley, S. P., 1987, An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts, J. Biol. Chem., 262:12745.
Konieczny, S. F., Drobes, B. L.,, Menke, S. L., and Taparowsky, E. J., 1989, Inhibition of myogenic differentiation by the H-ras oncogene is associated with the down regulation of the myoDl gene, Oncogene., 4:473.
Konigsberg, I. R., 1971, Diffusion-mediated control of myoblast fusion, Develop. Biol., 26:133.
Kovacina, K. S., Steele-Perkins, G., and Roth, R. A., 1989, A role of the Insulin-like Growth Factor II/mannose-6-phos-phate receptor in the insulin-induced inhibition of protein catabolism, Molec. Endocrinol., 3:901.
Kumegawa, M., Ikeda, E., Hosoda, S., and Takuma, T., 1980, In vitro effects of thyroxine and insulin on myoblasts from chick embryo skeletal muscle, Develop. Biol., 79:493.
Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., and Weintraub, H., 1989a, MyoD is a sequence specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer, Cell., 58:823.
Lassar, A. B., Thayer, M. J., Overell, R. W., and Weintraub, H., 1989b, Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoDl, Cell., 58:659.
Lim, R. W., and Hauschka, S. D., 1984, A rapid decrease in epidermal growth factor-binding capacity accompanies the terminal differentiation of mouse myoblasts in vitro, J. Cell. Biol., 98:739.
Linkhart, T A., Clegg, C. H., Lim, R. W., Merrill, G. F., Chamberlain, J. S., and Hauschka, S. D., 1982, Control of mouse myoblast commitment to terminal differentiation by mitogens. in Pearson, M. L., and Epstein, H. F. (Eds): Molecular and Cellular Biology of Myogenesis. Cold. Springs. Harbor. Conf., 8:877.
Loeb, J. N., and Strickland, S., 1987, Hormone binding and coupled response relationships in systems dependent on the generation of secondary mediators, Mol. Endocrinol., 1:75.
Mandel, J.L., and Pearson, M. L., 1974, Insulin stimulates myogenesis in a rat myoblast line, Nature., 251:618.
Massague, J., Cheifetz, S., Endo, T., and Nadal-Ginard, B., 1986, Type beta transforming growth factor is an inhibitor of myogenic differentiation, Proc. Natl. Acad. Sci. USA., 83:8206.
McCusker, R. H. and Clemmons, D. R., 1988, Insulin-like growth factor binding protein secretion by muscle cells: effect of cellular differentiation and proliferation, J. Cell. Physiol., 137 :505.
McCusker, R. H., Camacho-Hubner, C., and Clemmons, D. R., 1989, Identification of the types of insulin-like growth factor binding proteins that are secreted by muscle cells in vitro, J. Biol. Chem., 264:7795.
Mellas, J., Gavin, J. R., and Hammesman, M. R., 1986, Multiplication-Stimulating Activity-induced alkalinization of canine renal proximal tubular cells, J. Biol. Chem., 261:14437.
Miner, J. H., and Wold, B., 1990, Herculin, a fourth member of the myoD family of myogenic regulatory genes, Proc. Natl. Acad. Sci. USA., 87:1089.
Morgan, D. O., Edman, J. C., Standring, D. N., Fried, V. A., Smith, M. C., Roth, R. A., and Rutter, W. J., 1987, Insulinlike growth factor-II receptor as a multifunctional binding protein, Nature., 329:301.
Multhauf, C., and Lough, J., 1986, Interferon-mediated inhibition of differentiation in a murine myoblast cell line, J. Cell. Physiol., 126:211.
Mulle, C., Benoit, P., Pinset, C., Roa, M., and Changeux, J.-P., 1988, Calcitonin gene-related peptide enhances the rate of desensitization of the nicotinic acetylcholine receptor in cultured mouse muscle cells, Proc. Natl. Acad. Sci. USA, 85:5728.
Murphy, L. J., Bell, G. I., Duckworth, M. L., and Friesen, H. G., 1987, Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I., Endocrinol., 121:684.
Murre, C., McCaw, P. S., and Baltimore, D., 1989a, A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, myoD, and myc proteins, Cell., 56:777.
Murre, C., Mccaw, P.S., Vaessin, H., Caudy, M., Jan, L.Y., Cabrera, C.V., Hauschka, S., Lassar, A.B., and Baltimore, D., 1989b, Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence, Cell., 58:537.
Olson, E. N., 1990, MyoD family: A paradigm for development?, Genes. & Develop., 4:1454.
Olson, E. N., Sternberg, E., Hu, J. S., Spizz, G., and Wilcox, C., 1986, Regulation of myogenic differentiation by type beta transforming growth factor, J. Cell. Biol., 103:1799.
Olwin, B. B., and Hauschka, S. D., 1988, Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture, J. Cell. Biol., 107:761.
Ong, J., Yamashita, S., and Melmed, S., 1987, Insulin-like growth factor I induces c-fos messenger ribonucleic acid in L6 skeletal muscle cells, Endocrinology., 120:353.
Pinney, D. F., Pearson-White, S. H., Konieczny, S. F., Latham, K. E., and Emerson, C. P., Jr., 1988, Myogenic lineage determination and differentiation: evidence for a regulatory gene pathway, Cell., 53:781.
Rahm, M., Jin., P., Sumegi, J., and Sejersen, T., 1989, Elevated c-fos expression inhibits differentiation of L6 rat myoblasts, J. Cell. Physiol., 139:237.
Rechler, M. M., and Nissley, S. P., 1985, The nature and regulation of the receptors for insulin-like growth factors, Ann. Rev. Physiol., 47:425.
Rhodes, S. J., Konieczny, S. F., 1990, Identification of MRF4: A new member of the muscle regulatory factor gene family, Genes &Develop, in press
Roberts, A. B., and Sporn, M. B. The Transforming Growth Factor-betas., 1990, in sporn, M. B.,and roberts, A. B. eds peptide growth factors and their receptors, vol 1. Handbook of Exptl Pharm vol 95. Springer Verlag, Heidelberg,., :419.
Roeder, R.A., Thorpe, S. D., Byers, F. M., Schelling, G. T., and Gunn, J. M., 1986, Influence of anabolic agents on protein synthesis and degradation in muscle cells grown in culture, Growth., 50:485.
Roeder, R. A., Hossner, K. L., Sasser, R. G., and Gunn, J. M., 1988, Regulation of protein turnover by recombinant human insulin-like growth factor-I in L6 myotube cultures, Horm. Metabol. Res., 220:698.
Rosen, K.M., Wentworth, B. M., Rosenthal, N., and Villa-Komaroff, L., manuscript in preparation.
Rosenfeld, R. G., Pham, H., James, P., Shsh, R., Diaz, G., and wyche, J, 1987, Demonstration of a autocrine for insulinlike growth factor-II, medicated through the Type II receptor. (Abstract) Endocrinol. 120 (Suppl. 1): A89.
Roth, R. A., 1988, Structure of the receptor for insulin-like growth factor II: the puzzle amplified, Science., 239:1269.
Schmid, Ch., Steiner, Th., and Froesch, E. R., 1983, Preferentiatial enhancement of myoblast differentiation by insulin-like growth factors (IGF-I and IGF-II) in primary cultures of chicken embryonic cells, FEBS. Letters., 161:117.
Schmid, C., Steiner, T., and Froesch, E. R., 1984, Isulin-like growth factor I supports differentiation of cultured os-teoblast-like cells, FEBS. Letters., 173:48.
Schneider, M. D., and Olson, E. N., 1988, Control of myogenic differentiation by cellular oncogenes, Molecular. Neurobiol., 2:1.
Schubert, D., Harris, J., Devine, C. E., and Heinemann, S., 1974, Characterization of a unique muscle cell line, J. Cell. Biol., 61:398.
Shimizu, M., Webster, C., Morgan, D. O., Blau, H. M., and Roth, R. A., 1986, Insulin and insulinlike growth factor receptors and responses in cultured human muscle cells, Am. J. Physiol., 251:E611.
Spira, O., Atzmon, R., Rahamim, E., Bar-Shavit, R., Gross, J., Gordon, A., and Vlodavsky, I., 1988, Striated muscle fibers differentiate in primary cultures of adult anterior pituitary cells, Endocrinology., 122:3002.
Spizz, G., Roman, D., Strauss, A., and Olson, E. N., 1986, Serum and fibroblast growth factor inhibit myogenic differentiation through a mechanism dependent on protein synthesis and independent of cell proliferation, J. Biol. Chem., 261:9483.
Stylianopoulou, F., Efstratiadis, A. Herbert, J., and Pintar, J., 1988, Pattern of the insulin-like growth factor II gene expression during rat embryogenesis, Development., 103:4 97.
Tapscott, S. J., Davis, R. L., Thayer, M. J., Cheng, P.-F., Weintraub, H., and Lassar, A. B., 1988, MyoDl: A nuclear phosphoprotein requiring a myc homology region to convert fibroblasts to myoblasts, Science., 242:405.
Thayer, M. J., Tapscott, S. J., Davis, R. L., Wright, W. E., Lassar, A. B., and Weintraub, H., 1989, Positive autoregula-tion of the myogenic determination gene myoDl, Cell., 58:241.
Tollefsen, S. E., Lajara, R., McCusker, R. H., Clemmons, D. R., and Rotwein, P., 1989a, Insulin-like growth factors (IGF) in muscle development, expression of IGF-I, the IGF-I receptor, and an IGF binding protein during myoblast differentiation, J. Biol. Chem., 264:13810.
Tollefsen, S. E., Sadow, J. L., and Rotwein, P., 1989b, Coordinate expression of insulin-like growth factor II and its receptor during muscle differentiation, Proc. Natl. Acad. Sci. USA., 86:1543.
Turner, J. D., Rotwein, P., Novakofski, J., Bechtel, P. J., 1988, Induction of mRNA for IGF-I and -II during growth hormone-stimulated muscle hypertrophy, Am. J. Physiol., 255:E513.
Turo, K. A., and Florini, J. R., 1982, Hormonal stimulation of myoblast differentiation in the absence of DNA synthesis, Am. J. Physiol. (Cell. Physiol. 12)., 243:C278.
Vaidya, T. B., Rhodes, S. J., Taparowsky, E. J., and Konieczny, S. F., 1989, Fibroblast growth factor and transforming growth factor 15 repress transcription of the myogenic regulatory gene myoDl, Mol. Cell. Biol., 9:3576.
Wright, W. E., Sassoon, D. A., and Lin, V. K., 1989, Myogenin, a factor regulating-myogenesis, has a domain homologous to myoD, Cell., 56:607.
Yaffe, D., 1968, Retention of differentiation potentialities during prolonged cultivation of myogenic cells, Proc. Natl. Acad. Sci. USA., 61:477.
Yaffe, D., and Saxel, O., 1977, Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscles, Nature. (London)., 270:725.
Yu, K.-T., and Czech, M. P., 1984, Tyrosine phosphorylation of the insulin receptor B subunit activates the receptor-associated tyrosine kinase activity, J. Biol. Chem., 259:5277.
Zapf, J., Schoenle, E., Jagers, E., Sand, I., and Froesch, E. R., 1979, Inhibition of the actions of non-suppressible insulin-like activity on isolated fat cells by binding to its carrier protein, J. Clin. Invest., 63:1077.
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Magri, K.A., Ewton, D.Z., Florini, J.R. (1991). The Role of the IGFs in Myogenic Differentiation. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_6
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