Skip to main content

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 293))

  • 232 Accesses

Abstract

In rat and other mammalian species a single insulin-like growth factor I (IGF-I) gene gives rise to a heterogeneous and complex family of IGF-I mRNAs (1,2).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Hepler JE, Lund PK (1990) Molecular biology of the insulin-like growth factors: Revelance to nervous system function. Molecular Neurobiology: In Press.

    Google Scholar 

  2. Daughaday WH, Rotwein P (1989) Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocrine Reviews 10: 68–91.

    Article  PubMed  CAS  Google Scholar 

  3. Lund PK, Moats-Staats BM, Hynes MA, Simmons JG, Jansen M, D’Ercole AJ, Van Wyk JJ (1986) Somatomedin-Qlnsulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues. Journal of Biological Chemistry 261: 14539–14544.

    PubMed  CAS  Google Scholar 

  4. Casella S, Smith E, Van Wyk JJ, Joseph D, Hynes M, Hoyt E, Lund P (1987) Isolation of rat testis cDNA encoding an insulin-like growth factor I precursor. DNA 6: 325–330.

    Article  PubMed  CAS  Google Scholar 

  5. Hoyt E, Van Wyk JJ, Lund P (1988) Tissue and development specific regulation of a complex family of insulin-like growth factor I messenger ribonucleic acids. Molecular Endocrinology 2: 1077–1086.

    Article  PubMed  CAS  Google Scholar 

  6. Berger SL (1987) Direct mapping of rare mRNAs by means of oligomer-directed ribonuclease H cleavage. Anal Biochem 161: 272–279.

    Article  PubMed  CAS  Google Scholar 

  7. Irminger J, Rosen KM, Humbel RE, Villa-Komaroff L (1987) Tissue specific expression of insulin-like growth factor II mRNAs with distinct 5’ untranslated regions. Proc Natl Acad Sci USA 84: 6330–6334.

    Article  PubMed  CAS  Google Scholar 

  8. Lund PK, Hoyt E, Van Wyk JJ (1989) The size heterogeneity of rat insulin-like growth factor-I mRNAs is due primarily to differences in the length of 3,-untranslated sequence. Molecular Endocrinology 3: 2054–2061.

    Article  PubMed  CAS  Google Scholar 

  9. Wreschner D, Rechavi G (1988) Differential mRNA stability to reticulocyte ribonucleases correlates with 3’ non-coding (U)nA sequences. Eur J Biochem 172: 333–340.

    Article  PubMed  CAS  Google Scholar 

  10. Brawerman G (1987) Determinants of messenger RNA stability. Cell 48: 5–6.

    Article  PubMed  CAS  Google Scholar 

  11. Shaw G, Kamen R (1986) A conserved AU sequence from the untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46: 659–667.

    Article  PubMed  CAS  Google Scholar 

  12. Shyu A, Greenberg M, Belasco J (1989) The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways. Genes &Development 3: 60–72.

    Article  CAS  Google Scholar 

  13. Hepler JE, Van Wyk JJ, Lund PK (1990) Different half-lives of insulin-like growth factor mRNAs that differ in length of 3’ untranslated sequence. Endocrinology 127: 1550–1552.

    Article  PubMed  CAS  Google Scholar 

  14. Lowe W, Adamo M, Leroith D, Roberts C (1989) Expression and stability of insulin-like grwoth factor-I (IGF-I) mRNA splicing variants in the GH3 rat pituitary cell line. Biochem Biophys Res Comm 162: 1174–1179.

    Article  PubMed  CAS  Google Scholar 

  15. Straus DS, Takemoto CD (1990) Effect of dietary protein deprivation on insulin-like growth factor (IGF)-I and II, IGF binding protein-2 and serum albumin gene expression in rat. Endocrinology 127: 1849–1859.

    Article  PubMed  CAS  Google Scholar 

  16. Thiessen JP, Underwood LE (1991) Translational status of the insulin like growth factor I mRNAs in liver of protein restricted rats. Mol. Endocrinol, submitted.

    Google Scholar 

  17. Kato H, Miura Y, Okoshi A, Umezawa T, Takahashi S, Noguchi T (1989) Dietary and hormonal factors affecting the mRNA level of IGF-I in rat liver in vivo and in primary cultures of rat hepatocytes. In: Leroith D, Raizada MK (eds) Molecular and Cellular Biology of Insulin-Like Growth Factors and Their Receptors. Plenum Press New York 125–128.

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Plenum Press, New York

About this chapter

Cite this chapter

Lund, P.K., Hoyt, E.C., Van Wyk, J.J. (1991). Structural and Functional Characterization of IGF-I RNA 3’ Variants. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_2

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5949-4_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5951-7

  • Online ISBN: 978-1-4684-5949-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics