Abstract
Virtually all of the insulin-like growth factors (IGFs) in extracellular fluids and cell culture medium occur complexed to specific IGF-binding proteins (IGFBPs).1,2 The IGFBPs are a family of proteins that bind IGF-I and IGF-II but are unrelated to IGF receptors. Four IGFBPs have been cloned from human and rat sources,1–8 and partial protein sequence information is available forafifthlGFBP.9–11 OthermembersoftheIGFBPfamilyundoubtedlyexist,12butspecific assignment must await amino acid or nucleotide sequencing.
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© 1991 Plenum Press, New York
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Rechler, M.M., Brown, A.L., Ooi, G.T., Orlowski, C.C., Tseng, L.YH., Yang, Y.WH. (1991). Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2. In: Raizada, M.K., LeRoith, D. (eds) Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors. Advances in Experimental Medicine and Biology, vol 293. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5949-4_13
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DOI: https://doi.org/10.1007/978-1-4684-5949-4_13
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