Abstract
Peroxidation of membrane lipids is thought be a dynamic process which is ongoing in virtually all cells. Under normal conditions, cellular lipid peroxidation is well regulated and, as noted in a recent review (Esterbauer. et al. , 1990), is always associated with the formation of numerous and chemically diverse aldehydic products. Malondialdehyde (MDA) and trans-4-hydroxy-2-nonenal (HNE) are classified as major products of lipid peroxidation since they are present in the greatest quantities during peroxidation of cellular membrane lipids while trans-2-hexenal, acrolein and crotonaldehdye are representative of minor products of lipid peroxidation thought to be formed in significantly smaller quantities.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Alin, P., Danielson, H. and Mannervik, B., 1985, 4-hydroxyalk-2-enals are substrates for glutathione transferase, FEBS Lett., 179:267.
Benedetti, A., Comporti, M. and Esterbauer, H., 1980, Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipids, Biochim. Biophys. Acta, 620:281.
Canuto, R.A., Garcea, R., Biocca, M.E., Pascale, R., Pirisi, L. and Feo, F., 1983, The subcellular distribution and properties of aldehyde dehydrogenase of hepatoma AH-130, Eur. J. Cancer Clin. Oncol., 19:389.
Canuto, R.A., Biocca, M.E., Muzio, G., Garcea, R. and Dianzani, M.U., 1985, The effect of various aldehydes on the respiration of rat liver and hepatoma AH-130 cells, Cell Biochem. Funct., 3:3.
Cheeseman, K.H., Collins, M., Maddix, S., Milia, A., Proudfoot, K., Slater, T.F., Burton, G.W., Webb, A.C. and Ingold, K.U., 1986a, Lipid peroxidation in regenerating rat liver, FEBS Lett., 209:191.
Cheeseman, K.H., Collins, M., Proudfoot, K., Slater, T.F., Burton, G.W., Webb, A.C. and Ingold, K.U., 1986b, Studies on lipid peroxidation in normal and tumour tissues. The Novikoff rat liver tumour, Biochem. J., 235:507.
Danielson, U.H., Esterbauer, H. and Mannervik, B., 1987, Biochem. J., Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases, 247:707.
Dianzani, M.U., 1982, Biochemical effects of saturated and unsaturated aldehydes, in: “Free radicals, Lipid peroxidation and Cancer”, D.C.H. Mc Brian and T.F.Slater, eds, Academic Press, New York/London.
Esterbauer, H., Cheeseman, K.H., Dianzani, M.U., Poli, G. and Slater, T.F., 1982a, Separation and characterization of2+the aldehydic products of lipid peroxidation stimulated by ADP-Fe in rat liver microsomes, Biochem. J., 208:129.
Esterbauer, H., 1982b, Aldehydic products of lipid peroxidation, in: “Free radicals, Lipid peroxidation and Cancer”, D.C.H. Mc Brian and T.F.Slater, eds, Academic Press, New York/London.
Esterbauer, H., Zollner, H. and Lang, J., 1985a, Metabolism of the lipid peroxidation product 4-hydroxynonenal by isolated hepatocytes and by liver cytosolic fractions, Biochem. J., 228:363.
Esterbauer, H., 1985b, Lipid peroxidation products: formation, chemical properties and biological activities, in: “Free radicals in liver injury”, G. Poli, K.H. Cheeseman, M.U. Dianzani, T.F.Slater, eds, IRL Press, Oxford, England.
Ferro, M., Marinari, U.M., Poli, G., Dianzani, M.U., Fauler, G., Zollner, H. and Esterbauer, H., 1988, Metabolism of 4-hydroxynonenal by the rat hepatoma cell line MH1C1, Cell Biochem. Funct., 6:245.
Gornall, A.G., Bardawill, C.J. and David, M., 1949, Determination of serum proteins by means of the biuret reaction, J. Biol. Chem., 177:751.
Hauptlorenz, S., Esterbauer, H., Moll, W., Pumpel, R., Schauenstein, E. and Puschendorf, B., 1985, Effects of the lipidperoxidation product 4-hydroxynonenal and related aldehydes on proliferation and viability of cultured Ehrlich ascites tumor cells, Biochem. Pharmacol., 34:3803.
Lin, K-H, Leach, M.F., Winters, A.L. and Lindahl, R., 1986, Characteristics and aldehyde dehydrogenase activity of four rat hepatoma cell lines produced by diethylnitrosamine-phenobarbital treatment, In Vitro Cell Develop. Biol., 22:263.
Lindahl, R. and Evces, S., 1984, Rat liver aldehyde dehydrogenase. I. Isolation and characterization of four high Km normal liver isoenzymes, J. Biol. Chem., 259:11986.
Lindahl, R. and Evces, S., 1987, Changes in aldehyde dehydrogenase activity during diethylnitrosamine-initiated rat hepatocarcinogenesis, Carcinogenesis, 8:785.
Mitchell, D.Y. and Petersen, D.R., 1987, The oxidation of - unsaturated aldehydic products of lipid peroxidation by rat liver aldehyde dehydrogenase, Toxicol. Appl. Pharmacol., 87:403.
Poli, G., Gravela, E., Albano, E. and Dianzani, M.U., 1979, Studies on fatty liver with isolated hepatocytes, Exp. Mol. Pathol., 30:116.
Poli, G., Dianzani, M.U., Cheeseman, K.H., Slater, T.F., Lang, J. and Esterbauer, H., 1985, Separation and characterization of the aldehydic products of lipid peroxidation stimulated by carbon tetrachloride or ADP-iron in isolated rat hepatocytes and rat liver microsomal suspensions, Biochem. J., 227:629.
Poli, G., Cecchini, G., Biasi, F., Chiarpotto, E., Canuto, R.A., Biocca, M.E., Muzio, G., Esterbauer, H. and Dianzani, M.U., 1986, Resistance to oxidative stress by hyperplastic and neoplastic rat liver tissue monitored in terms of production of unpolar and medium polar carbonyls, Biochim. Biophys. Acta, 883:207.
Schauenstein, E., Esterbauer, H. and Zollner, H., 1977, In: Aldehydes in Biological Systems, their natural occurrence and biological actvities. Pion Limited, London.
Tottmar, O., Pettersson, H., Kiessling, K.H., 1973, The subcellular distribution and properties of aldehyde dehydrogenase in rat liver, Biochem. J., 135:577.
Weiner, H. and Wermuth, B., 1982, in: “Enzymology of carbonyl metabolism: aldehyde dehydrogenase and aldo-keto reductase”, A.R. Liss, New York.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Plenum Press, New York
About this chapter
Cite this chapter
Canuto, R.A. et al. (1990). Metabolism of 4-Hydroxynonenal in Hepatoma Cell Lines. In: Weiner, H., Wermuth, B., Crabb, D.W. (eds) Enzymology and Molecular Biology of Carbonyl Metabolism 3. Advances in Experimental Medicine and Biology, vol 284. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5901-2_10
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5901-2_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5903-6
Online ISBN: 978-1-4684-5901-2
eBook Packages: Springer Book Archive