Abstract
The phenotypic sex develops as a result of gonadal differentiation, which again usually reflects the genetic sex. In spite of numerous studies, the mechanisms which control gonadal sex differentiation are still not clear. Neither sex steroids nor gonadotropins direct the process (1). Specific gene products of the Y-chromosome have been proposed to control testicular differentiation, e.g., the HY-antigen (histocompatability Y-antigen) (2) and the TDF (testis determining factor) (3).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Byskov AG. Differentiation of mammalian embryonic gonad. Physiol Rev 1986; 66:71–117.
Wachtel SS. H-Y antigen in gonadal differentiation. In: Austin CR, Edwards RG, eds. Mechanisms of sex differentiation in animals and man. London, New York: Academic Press, 1981:255–99.
Page DC, Mosher R, Simpson EM, et al. The sex-determining region of the human Y chromosome encodes a finger protein. Cell 1987; 51:1091–1104.
Byskov AG. Regulation of meiosis in mammals. Ann Biol Anim Biochem Biophys 1979;19:1251–61.
Fajer AB, Schneider J, McCall D, Ances IG, Polakis SE. The induction of meiosis by ovaries of newborn hamsters and its relation to the action of the extraovarian structures in the mesovarium (rete ovarii). Ann Biol Anim Biochem Biophys 1979; 19:1273–8.
Westergaard LG. Intrafollicular factors regulating human ovarian follicular development and oocyte maturation. Dan Med Bull 1988 (in press).
Taketo T, Thau RB, Adeyemo O, Koide SS. Influence of adenosine 3’:5’-cyclic monophosphate analogues on testicular organization of fetal mouse gonads in vitro. Biol Reprod 1984; 30:189–98.
Magre S, Agelopoulou R, Jost A. Action du serum de veau sur la differenciation in vitro on le maintien des cordon seminiferes du testicule du faetus du rat. C R Acad Sci (Paris) 1981; 292:85–9.
Agelopoulou R, Magre S, Patsavoudi E, Jost A. Initial phases of the rat testis differentiation in vitro. J Embryol Exp Morphol 1984; 83:15–31.
Byskov AG, Fenger M, Hansen JL, Husum I, Bagger P. Second messengers in control of onset of meiosis in fetal mice. 1988 (submitted).
Daly JW. Forskolin, adenylate cyclase, and cell physiology: an overview. In: Greengard P, ed. Advances in cyclic nucleotide and protein phosphorylation research. New York: Raven Press, 1984:81–9.
Joso N, Picard J-Y. Anti-Mullerian hormone. Physiol Rev 1986; 66:1038–90.
Drummond AH, Joels LA, Hughes PJ. The interaction of lithium ions with lipid signalling systems. Biochem Soc Trans 1987; 15:32–5.
Mork A, Geisler A. Mode of action of lithium on the catalytic unit of adenylate cyclase from rat brain. Pharmacol Toxicol 1987; 60:241–8.
Tomooka Y, Imagawa W, Nandi S, Bern HA. Growth effect of lithium on mouse mammary epithelial cells in serum-free collagen gel culture. J Cell Physiol 1983; 117:290–6.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Byskov, A.G., Tinggaard, H., Andersen, C.Y. (1989). Role of Second Messengers in Early Differentiation of Gonads and Sex Ducts. In: Hirshfield, A.N. (eds) Growth Factors and the Ovary. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5688-2_3
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5688-2_3
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5690-5
Online ISBN: 978-1-4684-5688-2
eBook Packages: Springer Book Archive