Abstract
The three groups of peptides, the bombesins, sauvagine and the dermor-phins were first isolated from amphibian skin (Erspamer and Melchiorri, 1980a; Erspamer and Melchiorri, 1980b; Erspamer et al., 1980; Montecucchi et al., 1981; Montecucchi, 1981) and preceded the discovery of analogous peptides in mammalian tissues. Skin peptides have revealed interesting and unexpected actions both on the CNS and the endocrine system showing a wide range of activities. Their use in contributing to the understanding of the mechanisms underlying the central regulation of several visceral functions, the peripheral regulation of gut secretion and mobility, and the control of the release of hypophysary hormones is the basis for the ever growing interest in this group of peptides.
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References
Abe, H., Chihara, K., Minamitani, N., Iwasaki, J., Chiba, T., Matsukura, S., and Fujita, T., 1981, Stimulation by Bombesin of Immunoreactive Somatostatin Release into Rat Hypophyseal Portal Blood, Endocrinology, 109:229.
Broccardo, M., Falconieri Erspamer, G., Melchiorri, P., Negri, L., and de Castiglione, R., 1975, Relative Potency of Bombesin-Like Peptides, Br. J. Pharmac., 55:221.
Brown, M., and Vale, W., 1979, Somatostatin: Central Nervous System Actions on Glucoregulation, Endocrinology, 104:1709.
Brown, M., and Vale, W., 1981, in: Diabetes Mellitus: Diagnosis and Treatment, H. Rifin, and P. Raskin, eds., R. J. Brady Co., Bowie, MD, pp. 55-62.
Brown, M., Rivier, J., Kobayashi, R., and Vale, W., 1978, in: Gut Hormones, S. R. Bloom, ed., Churchill Livingstone, Edinburgh, pp. 550–558.
Brown, M., Taché, Y., Rivier, J., and Pittman, Q., 1981, Peptides and Regulation of Body Temperature, Adv. Biochem. Psychopharmacol., 94:132613c.
Burstein, E. A., Vedenkina, N. S., and Ivkova, M. N., 1973, Fluorescence and the Location of Tryptophan Residues in Protein Molecules, Photochem. Photobiol., 18:263.
Cevc, G., Watts, A., and Marsh, D., 1981, Titration of the Phase Transition of Phosphatidylserine Bilayer Membranes. Effects of pH, Surface Electrostatics, Ion Binding and Head-Group Hydration, Biochemistry, 20:4955.
Cuttitta, F., Carney, D. N., Mulshine, J., Moody, T. W., Fedorko, J., Fischler, A., and Minna, J. D., 1985, Bombesin-like Peptides can Function as Autocrine Growth Factors in Human Small-cell Lung Cancer, Nature, 316:823.
De Caro, G., Massi, M., and Micossi, L. G., 1980, Modifications of Drinking Behaviour and of Arterial Blood Pressure Induced by Tachykinesis in Rats and Pigeons, Psychopharmacology, 68:243.
Dubrasquet, M., Rozé, C., Ling, N., and Florencio, H., 1982, Inhibition of Gastric and Pancreatic Secretions by Cerebroventricular Injections of Gastrin-Releasing Peptide and Bombesin in Rats, Regul. Peptides, 3:105.
Erspamer, V., and Melchiorri, P., 1980a, Amphibian Skin Peptides and Mammalian Neuropeptides, in: Growth Hormone and Other Biologically Active Peptides, A. Pecile, and E. E. Muller, eds., Excerpta Medica, Amsterdam, pp 185–200.
Erspamer, V., and Melchiorri, P., 1980b, Active Polypeptides from Amphibian Skin to Gastrointestinal Tract and Brain of Mammals, Trends Pharmacol. Sci., 1:391.
Erspamer, V. and Melchiorri, P., 1983, Actions of Amphibian Skin Peptides on the Central Nervous System and the Anterior Pituitary, in: Neuroendocrine Perspectives, E. Muller, and R. M. MacLeod, eds., Vol. 2. Elsevier, New York, pp. 37–106.
Erspamer, V., Falconieri Erspamer, G., Improta, G., Negri, L., and de Castiglione, R., 1980, Sauvagine, A New Polypeptide from Phyllomedusa sauvagei Skin, Naunyn-Schmiedeberg’s Arch. Pharmacol., 312:265.
Jahnig, F., 1983, Thermodynamics and Kinetics of Protein Incorporation into Membranes, Proc. Natl. Acad. Sci. USA, 80:3691.
Knutson, J. R., Wallbridge, D. G., and Brand, L., 1982, Decay-Associated Fluorescence Spectra and the Heterogeneous Emission of Alcohol Dehydrogenase, Biochemistry, 21:4671.
Kyte, J. and Doolittle, R. F., 1982, A Simple Method for Displaying the Hydropathic Character of a Protein, J. Mol. Biol., 157:105.
MacKinnon, A. E., Szabo, A. G., and Miller, D. R., 1977, The Deconvolution of Photoluminescence Data, J. Phys. Chem., 81:1564.
Martin, C. F., and Gibbs, J., 1980, Bombesin Elicits Satiety in Sham Feeding Rat, Peptides, 1:131.
Montecucchi, P. C., de Castiglione, R., Piani, S., Gozzini, L., and Erspamer, V., 1981, Identification of Dermorphin and Hyp6-Dermorphin in Skin Extracts of the Brazilian Frog Phyllomedusa Rhodei, Int. J. Peptide Protein Res., 17:316.
Montecucchi, P. C., de Castiglione, R., Piani, S., Gozzini, L., and Erspamer, V., 1981, Amino Acid Composition and Sequence of Dermorphin, A Novel Opiate-Like Peptide from the Skin of Phyllomedusa Sauvagei, Int. J. Peptide Protein Res., 17:275.
Moody, T. W., Pert, C. B., Rivier, J., and Brown, M. R., 1978, Bombesin: Specific Binding to Rat Brain Membranes, Proc. Natl. Acad. Sci. USA, 75:5372.
Rivier, C., Rivier, J., and Vale, W., 1978, The Effect of Bombesin and Related Peptides on Prolactin and Growth Hormone Secretion in the Rat, Endocrinology, 102:519.
Szabo, A. G., and Rayner, D. M., Fluorescence Decay of Tryptophan Conformers in Aqueous Solution, 1980, J. Am. Chem. Soc., 102:554.
Westendorf, J. M., and Schombrunn, A., 1982, Bombesin Stimulates Prolactin and Growth Hormone Release by Pituitary Cells in Culture, Endocrinology, 110:352.
Zuker, M., Szabo, A. G., Bramall, L., Krajcarski, D. T., and Selinger, B., 1985, Delta Function Convolution Method (DFCM) for Fluorescence Decay Experiments, Rev. Sci. Instrum., 56:14.
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© 1989 Plenum Press, New York
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Masotti, L., Cavatorta, P., Szabo, A.G., Farruggia, G., Sartor, G. (1989). Conformational Flexibility of the Polypeptide Hormone Bombesin: Time Resolved and Static Fluorescence Studies. In: Jameson, D.M., Reinhart, G.D. (eds) Fluorescent Biomolecules. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5619-6_12
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DOI: https://doi.org/10.1007/978-1-4684-5619-6_12
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