Abstract
The regulation of Na-phosphate cotransport across the apical membrane can, in analogy to classical enzymology, be divided into: short-term and long-term regulation. Short-term regulation involves: (i) allosteric and (ii) other activation-inactivation processes, e.g. covalent modifications such as phosphorylation or ADP-ribosylation. Long-term regulation usually involves de novo synthesis of the cotransporter. An additional regulatory mechanism can be considered for plasma membrane-bound systems: regulation via insertion or withdrawal of transporter from the membranes (endo-/exocytosis; for review see: Gmaj and Murer, 1985; Kempson and Dousa, 1985).
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© 1986 Plenum Press, New York
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Murer, H., Biber, J., Malmström, K., Mohrmann, I., Coady, M. (1986). Regulation of Na-Phosphate Cotransport in Cultured Renal Epithelial Cells: Protein-Synthesis-Dependent and Protein-Synthesis-Independent Pathways. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_7
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DOI: https://doi.org/10.1007/978-1-4684-5206-8_7
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