Abstract
Since the pioneering experiments of Grenell (1), who demonstrated neuronal necrosis in dogs after periods of ischemia from only two to less than ten minutes, there has been controversy as to the minimum time necessary to produce permanent brain damage after ischemia. The maximum duration of ischemia which the animal can survive indefinitely (“revival time”) has also been the subject of some dispute, with times as long as one hour having been reported for recovery of at least basic neurophysiologic functions (2,3).
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© 1986 Plenum Press, New York
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Auer, R.N., Smith, ML., Siesjö, B.K. (1986). Ischemic Brain Damage in the Rat in a Long Term Recovery Model. In: Baethmann, A., Go, K.G., Unterberg, A. (eds) Mechanisms of Secondary Brain Damage. NATO ASI Series, vol 115. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5203-7_7
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DOI: https://doi.org/10.1007/978-1-4684-5203-7_7
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