Abstract
Various types of injury have been shown to produce a variety of chemical changes in brain which are thought to underly functional disturbances resulting from the particular insult. Some of the systems known to be affected in injured brain are summarized in Figure 1, but the list is by no means exhaustive. The exact mechanisms by which the chemical perturbations are related to functional disturbances are not understood in most cases and it is often difficult to distinguish between the cause and the effect in this relationship. One problem has been the difficulty in assessing neurological function in animals since normalization of neurochemical disturbances in brain cannot always be equated with normally functioning central nervous system and the available methods are not necessarily applicable in the particular experimental situation.
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Pappius, H.M., Wolfe, L.S. (1986). Neurochemical Sequelae of Brain Damage and Their Role in Functional Disturbances. In: Baethmann, A., Go, K.G., Unterberg, A. (eds) Mechanisms of Secondary Brain Damage. NATO ASI Series, vol 115. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5203-7_12
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