Abstract
In pesticide manufacture and usage, human exposure is minimized at every stage. The need to monitor this is the main impetus to the study of pesticide metabolism in man. That of selected pesticides, initially in animals, has been studied as part of industrial hygiene research programmes to indicate the most suitable analytical methods for monitoring exposure. These typically entail GC-ECD, and their development is in general based on a common major urinary metabolite or on the pesticide itself. Dose-excretion studies enable assays to be made on manufacturing operatives, formulators and sprayers.
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References
Feldman, R.J. & Maibach, H.I. (1974)Toxicol. Appl. Pharmacol. 28, 126–132.
Bull, D.L. & Lundquist, D.A. (1966)J. Agric. Food Chem. 14, 105–109.
Beynon, K.I., Hutson, D.H. & Wright, A.N. (1973)Residue Rev. 47, 55–142.
Shafik, T., Bradway, D.E., Enos, H.F. & Yobbs, A.R. (1973)J. Agric. Food Chem. 21, 625–629.
Shafik, M.T. & Enos, H.F. (1969)J. Agric. Food Chem. 17, 1186–1189.
Blair, D. & Roderick, H.R. (1976)J. Agric. Food Chem. 24, 1221–1222.
Ottenvanger, C.F. (1976) An Epidemiological and Toxicological Study of Occupational Exposure to an Organophosphorus Pesticide, Phoenix & Den Oudsten, Rotterdam, 188 pp. 133
Hutson, D.H., Akintonwa, D.A.A. & Hathway, D.E. (1967)Biochem. J. 102, 133–142.
Hutson, D.H., Holmes, D. & Crawford, M.J. (1976)Chemosphere5, 79–84.
Hunter, C.G., Robinson, J., Bedford, C.T. & Lawson, J.M. (1972)J. Occup. Med. 14, 119–122.
Casida, J.E., Gaughan, L.C. & Ruzo, L.O. (1976) in Advances in Pesticide Science (4th Internat. Congr. Pestic. Chem., Zurich, 1978 ) , Vol. 2, Pergamon, Oxford, pp. 182–189.
Hutson, D.H. (1979) in Progress in Drug Metabolism (Bridges, J.W. & Chasseaud, L.G., eds.) , Vol. 3, Wiley, Chichester, pp. 215–252.
Casida, J.E. & Ruzo, L.O. (1980)Pestic. Sci. 11, 257–269.
Gaughan, L.C., Unai, T. & Casida, J.E. (1977)J. Agric. Food Chem. 25, 9–17.
Hutson, D.H. & Casida, J.E. (1978)Xenobiotica8, 565–571.
Gaughan, L.C., Ackerman, M.E., Unai, T. & Casida, J.E. (1978)Agric. Food Chem. 26, 613–618.
Hirom, P.C., Millburn, P., Smith, R.L. & Williams, R.T. (1972)Biochem. J. 129, 1071–1077.
Baldwin, M.K. & Hutson, D.H. (1980)Xenobiotica10, 135–144.
Glinsukon, T., Benjamin, T., Grantham, P.H., Weisburger, E.K. & Roller, P.R. (1975)Xenobiotica5, 475–483.
Beckett, A.H. & Belanger, P.M. (1976)Biochem. Pharmac. 25, 211–214
Parke, D.V. (1978) in Drug Metabolism in Man (Gorrod, J.W. & Beckett, A.H., eds.) , Taylor & Francis, London, p. 63–69.
Hunter, C.G. & Robinson, J. (1967)Arch. Environ. Health15, 614–626.
Hutson, D.H. (1976)Food Cosmet. Toxicol. 14, 577–591.
Müller, W., Nohynek, G., Woods, G., Körte, F. & Coulston, F. (1975)Chemosphere4, 89–92.
Richardson, A., Robinson, J., Bush, B. & Davies, J.M. (1967)Arch. Environ. Health14, 703–708.
Hutson, D.H., Baldwin, M.K. & Hoadley, E.C. (1975)Xenobiotica5, 697–714.
Baldwin, M.K., Crayford, J.V., Hutson, D.H. & Street, D.L. (1976)Pestic. Sci. 7, 575–594.
Baldwin, M.K. & Hutson, D.H. (1980)Analyst105, 6O–65.
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© 1983 Plenum Press, New York
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Eadsforth, C.V. (1983). Investigation of Pesticide Metabolites in the Human. In: Reid, E., Leppard, J.P. (eds) Drug Metabolite Isolation and Determination. Methodological Surveys in Biochemistry and Analysis, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4484-1_16
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DOI: https://doi.org/10.1007/978-1-4684-4484-1_16
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