Abstract
A wide variety of chemicals has been shown to be capable of inducing malignant tumors in rodents. However, rodent data are difficult to extrapolate to man, and the problem of risk assessment for humans remains largely unsolved. Extrapolation of rodent carcinogenesis data to man is particularly difficult because of known species differences in metabolic pathways (both activation and detoxification), involving potentially carcinogenic chemicals. Nonhuman primates are phylogenetically closer to man than rodents, and many metabolic pathways in monkeys parallel those in humans (1,2). For this reason, nonhuman primates may provide a more suitable model for the study of potential carcinogens, particularly those requiring metabolic activation and those detoxified by various enzyme systems.
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© 1983 Plenum Press, New York
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Adamson, R.H., Sieber, S.M. (1983). Chemical Carcinogenesis Studies in Nonhuman Primates. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_7
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_7
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