Abstract
Extensive studies on several species of laboratory animals have been done for only a few carcinogenic aromatic amines or amides; those so tested include benzidine, 4-aminobiphenyl, 2-acetylaminofluorene (AAF), and 2-aminonaphthalene (1). Even for these known carcinogens there are sizable variations in species response; the most striking occurs with AAF where at least 15 species have been tested (2). With this compound the guinea pig, cotton rat, monkey, steppe-lemming, and X/Gf mouse, among the mammals, have shown resistance to the carcinogenic effects. Metabolic studies, either in vivo or in vitro, have not always provided satisfactory explanations for these differences (3,4,5).
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© 1983 Plenum Press, New York
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Weisburger, E.K. (1983). Species Differences in Response to Aromatic Amines. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_2
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_2
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