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Endocrine Regulation of Xenobiotic Conjugation Enzymes

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Organ and Species Specificity in Chemical Carcinogenesis

Part of the book series: Basic Life Sciences ((BLSC))

Abstract

The balance of events involved in the activation/deactivation of xenobiotics is enormously complex. The metabolic activation of non-toxic chemicals to compounds that are reactive intermediates has been implicated in a wide variety of toxic reactions including carcinogenesis, teratogenesis, and toxicity (1–3). Figure 1 illustrates the enzymatic transformation of benzo[a]pyrene (BP) to reactive intermediates, primarily BP-epoxides. These electrophilic compounds can bind to DNA or to other cellular macromolecules to initiate toxicity. Toxic metabolites of polycyclic aromatic hydrocarbons can be enzymatically deactivated by a number of enzyme systems, such as the glutathione S-transferases, glucuronyltransferases, and sulfotransferases.

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Authors and Affiliations

  1. Laboratory of Organ Function and Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27709, USA

    Coral A. Lamartiniere & George W. Lucier

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  1. Coral A. Lamartiniere
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  2. George W. Lucier
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA

    Robert Langenbach  & Stephen Nesnow  & 

  2. National Cancer Institute, Bethesda, Maryland, USA

    Jerry M. Rice

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© 1983 Plenum Press, New York

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Lamartiniere, C.A., Lucier, G.W. (1983). Endocrine Regulation of Xenobiotic Conjugation Enzymes. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_16

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  • DOI: https://doi.org/10.1007/978-1-4684-4400-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4402-5

  • Online ISBN: 978-1-4684-4400-1

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