Abstract
Although numerous species and organ differences in the biotransformation of foreign organic chemicals, including chemical carcinogens, have been reported in the literature (for recent reviews see references 1–8), in most instances the studies were not designed for rigorous comparative analyses. Often the differences were noted only as interesting sidelights of a study that did not focus upon precise comparative aspects. Nevertheless, profound differences are known to exist and research on biotransformation in recent years has provided considerable evidence for the existence of numerous species-specific, organ-specific, and cell-specific isozymic forms of the well-known xenobiotic-biotransforming enzymes.
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Juchau, M.R. (1983). Species and Organ Differences in the Biotransformation of Chemical Carcinogens. In: Langenbach, R., Nesnow, S., Rice, J.M. (eds) Organ and Species Specificity in Chemical Carcinogenesis. Basic Life Sciences. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4400-1_14
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DOI: https://doi.org/10.1007/978-1-4684-4400-1_14
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