Abstract
The mixed lymphocyte culture reaction represents the in vitro counterpart of the recognition phase of the graft-versus-host reaction, and of allograft rejection. The mixed lymphocyte culture reactivities of lymph node and spleen cells from all strains of mice studied, including long-lived strains, and of thymus cells from most strains show a striking decline with advanced age. Furthermore, studies of “synergy” between subpopulations of T cells in the mixed lymphocyte culture reaction suggest that the cells of the recirculating lymphoid pool (T2 cells) in particular display a functional decline. Finally, spleen cells from old mice of appropriate strains inhibit or suppress the mixed lymphocyte culture reactivity of lymph node or spleen cells from young mice.—Gerbase-DeLima, M., P. Meredith and R. L. Walford. Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice. Federation Proc. 34: 159–161, 1975.
From Session V, Development and Aging in Organ Systems, of the FASEB Conference on Biology of Development and Aging, presented at the 58th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 11, 1974.
This study was supported by Public Health Service Grants CAl2788 and HD00534
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Abbreviations
- MLC:
-
mixed lymphocyte culture
- GVH:
-
graft-versus-host
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Gerbase-DeLima, M., Meredith, P., Walford, R.L. (1975). Age-related changes, including synergy and suppression, in the mixed lymphocyte reaction in long-lived mice. In: Thorbecke, G.J. (eds) Biology of Aging and Development. Faseb Monographs, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2631-1_30
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