Abstract
Effects of prenatal and postnatal zinc deficiency on the composition of the brain and on subsequent adult behavior were studied. Deficiency throughout the latter third of pregnancy resulted in decreased body and brain size without affecting total brain DNA, RNA, or protein. Adult males that had been subjected to intrauterine zinc deficiency displayed impaired shock avoidance. Zinc deficiency from birth until 21 days of age resulted in impaired growth, decreased brain size, diminished brain DNA, RNA and protein. Cerebellar lipid concentration was also diminished. Such male animals displayed impaired maze acquisition as adults.—Sandstead, H. H., G. J. Fosmire, J. M. McKenzie and E. S. Halas. Zinc deficiency and brain development in the rat. Federation Proc. 34: 86–88, 1975.
From Session IV, Aging of homeostatic control systems, of the FASEB Conference on Biology of Development and Aging, presented at the 58th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N. J., April 10, 1974.
Supported in part by the USDA Cooperative Agreement 12-14-100-11, 178 (61), Amend. 1.
Public Health Service, International Research Fellow.
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Fosmire, G. J., Y. Y. Al-Ubaidi, E. S. Halas, H. H. S,stead. Proceedings of the ACS symposium on protein-metal interactions. Adv. Expel. Med. Biot. 48: 329 - 345, 1974.
Fosmire, G. J., Y. Y. Albaidi,H. H. S ,stead. Some effects of postnatal zinc deficiency on developing rat brain. Pediat. Res. In press.
Fosmire, G. J.,, H. H. S,stead. Some effects of zinc deficiency on postnatal cerebellar development in the rat. Federation Proc. 33: 662, 1974.
Fosmire, M A., G. J. Fosmire, H. H. Sstead. Effects of zinc deficiency on polysomes. Federation Proc. 33: 699, 1974.
Grey, P. C.,, I. E. Dreosti. Deoxyribonucleic acid, protein metabolism in zinc-deficient rats. J. Comp. Pathol. 82: 223 - 228, 1972.
Halas, E. S., M. C. Rowe, O. R. Johnson, J. M. Mckenzie, H. H. S ,stead. Effects of intra-uterine zinc-deficiency on subsequent behavior. In: International Symposium on Trace Elements in Human Health, Disease, edited by A. S. Prasad. New York: The Nutrition Foundation. In press.
Halas, E.S.H. H. S,stead. Some effects of prenatal zinc deficiency on behavior of the adult rat. Pediat. Res. In press.
Hsu, J. M., W. L. Anthony, P. J. Buchanan. Zinc deficiency, incorporation of 19C-labeled methionine into tissue proteins in rats. J. Nutr. 99: 425 - 432, 1969.
Lokken, P. M. Maze acquisition in the zinc deficient rat. M.S. Thesis. Gr, Forks: Univ. of North Dakota, 1973.
Lokken, P. M., E. S. Halas, H. H. S,stead. Influence of zinc deficiency on behavior. Proc. Soc. Expel. Biol. Med. 144: 680 - 682, 1973.
Luecke, R. W., M. E. Olman, B. V. Baltzer. Zinc deficiency in the rat: Effect on serum, intestinal alkaline phosphatase activities. J. Nutr. 94: 344 - 350, 1968.
Macapinlac, M. P., W. N. Pearson, G. H. Barney, W. 1. DARBY. Protein, nucleic acid metabolism in the testes of zinc-deficient rats. J. Nutr. 95: 569 - 577, 1968.
Mckenzie, J. M., G. J. Fosmire, H. H. S ,stead. Zinc deficiency in the prenatal rat. Proc. N. Dakota Acad. Sci. In press.
NRC/NAS Recommended Dietary Allowances, 1973.
Prasad, A. S.,, D. Oberleas. Ribonuclease, deoxyribonuclease activities in zinc-deficient tissues. J. Lab. Clin. Med. 82: 461 - 466, 1973.
Rubin, H. Inhibition of DNA synthesis in animal cells by ethylene diamine tetraacetate, its reversal by zinc. Proc. Natl. Acad. Sci. U.S. 69: 712 - 716, 1972.
S,stead, H. H. Zinc nutrition in the United States. Am. J. Clin. Nutr. 26: 1251 - 1260, 1973.
Sstead, H. H., D. D. Gillespie, R. N. Brady. Zinc deficiency: Effect on brain of the suckling rat. Pediat. Res. 6: 119 - 125, 1972.
Sstead, H. H.,, R. A. Rinaldi. Impairment of deoxyribonucleic acid synthesis by dietary zinc deficiency in the rat. J. Cellular Phys. 73: 81 - 84, 1969.
Sstead, H. H., A. S. Shukry, A. S. Prasad, M. K. Gabr, A. Hifney, N. Mokhtar, W. J. Darby. Kwashiorkor in Egypt. I. Clinical, biochemical studies, with special reference to plasma zinc, serum lactic dehydrogenase. Am. J. Clin. Nutr. 17: 15 - 26, 1965.
Scrutton, M. C., C. W. Wu, D. A. Goldthwait. The presence, possible role of zinc in RNA polymerase obtained from Escherichia coli. Proc. Natl. Acad. Sci. U.S. 68: 2497 - 2501, 1971.
Slater, J. P., A. S. Mildvan, A. Loeb. Zinc in DNA polymerase. Biochem. Biophys. Res. Comm. 44: 37 - 43, 1971.
Somers, M.,, E. J. Underwood. Ribonuclease activity, nucleic acid, protein metabolism in the testes of zinc-deficient rats. Australian J. Biol. Sci. 22: 1277 - 1281, 1969.
Somers, M.,, E. J. Underwood. Studies of zinc nutrition in sheep. II. The influence of zinc deficiency in ram lambs upon the digestibility of the dry matter, the utilization of the nitrogen, sulphur of the diet. Australian J. Agr. Res. 20: 899, 1969.
Terhune, M. W.,, H. H. S,-Stead. Decreased RNA polymerase activity in mammalian zinc deficiency. Science 177: 68 - 69, 1972.
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Sandstead, H.H., Fosmire, G.J., McKenzie, J.M., Halas, E.S. (1975). Zinc deficiency and brain development in the rat. In: Thorbecke, G.J. (eds) Biology of Aging and Development. Faseb Monographs, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2631-1_19
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DOI: https://doi.org/10.1007/978-1-4684-2631-1_19
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