Abstract
The experimental evidence relating to the hypothesis of finite cellular life is reviewed. It is emphasized that even if somatic cell production were limited its total potential would have to be vast to provide for extensive cellular regeneration. The actual limit of reproductive cell life would therefore not likely be reached in a normal life-span. It is proposed to test the hypothesis by deliberate exhaustion of stem-cell reserve, and iron-55 cytocide is described as an experimental system that might be applicable.—Reincke, U., H. Burlington, E. P. Cronkite and J. Laissue. Hayflick’s hypothesis: an approach to in vivo testing. Federation Proc. 34: 71–75, 1975.
From Session III, Finite versus infinite proliferative and functional capacities of cells, of the FASEB Conference on Biology of Development and Aging, presented at the 58th Annual Meeting of the Federation of American Societies for Experimental Biology, Atlantic City, N.J., April 10, 1974.
Research supported by the Atomic Energy Commission, the Leukemia Society of America, Inc., and by National Institutes of Health research grant number HL 15685-02.
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Reincke, U., Burlington, H., Cronkite, E.P., Laissue, J. (1975). Hayflick’s hypothesis: an approach to in vivo testing. In: Thorbecke, G.J. (eds) Biology of Aging and Development. Faseb Monographs, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-2631-1_15
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