Abstract
This paper relates spectroscopic determinations of myoglobin (Mb) saturation and PO2 in individual myocytes (Gayeski and Honig, 1986) to a mathematical model of O2 transport (Federspiel, 1983). A graphical analysis of model results is used to illustrate interactions among the main determinants of O2 transport between hemoglobin (Hb) and cytochrome. The results of the analysis are summarized in a plot called the O2 release curve. The results are qualitatively applicable to normal and pathophysiology, and to Mb-free tissues.
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© 1988 Plenum Press, New York
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Gayeski, T.E.J., Federspiel, W.J., Honig, C.R. (1988). A Graphical Analysis of the Influence of Red Cell Transit Time, Carrier-Free Layer Thickness, and Intracellular PO2 on Blood-Tissue O2 Transport. In: Mochizuki, M., Honig, C.R., Koyama, T., Goldstick, T.K., Bruley, D.F. (eds) Oxygen Transport to Tissue X. Advances in Experimental Medicine and Biology, vol 222. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-9510-6_3
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DOI: https://doi.org/10.1007/978-1-4615-9510-6_3
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