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Electroconformational Coupling and the Effects of Static and Dynamic Electric Fields on Membrane Transport

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Electromagnetic Fields and Biomembranes

Abstract

Life itself depends on the maintenance of electric fields across cell membranes, and on the propagation of electric currents. Even unicellular organisms have been shown to generate, and in turn respond to, minute electric signals. Larger electric perturbations, applied in an experimental context, can activate membrane enzymes (Johnstone and Laris, 1980; Serpersu and Tsong, 1983, 1984), be utilized as an energy source for the biosynthesis of ATP or the creation of chemical gradients across membranes (Witt et al., 1976; Serpersu and Tsong, 1983; Knox and Tsong, 1984), or lead to the formation of “pores” in the membrane through which small molecules can passively diffuse into and out of the cell (Kinosita and Tsong, 1977 a, b; Neumann et al., 1982; Tsong, 1983). This latter process is known as electroporation.

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References

  • Astumian, R. D., Chock, P. B., and Tsong, T. Y., 1986, J. Electrochem. Soc., 133: 124c.

    Google Scholar 

  • Astumian, R. D., Chock, P. B. Tsong, T. Y., Chen, Y.-d., and Westerhoff, H. V 1987a, Proc. Natl. Acad Sci. U.S.A., 84: 434–438.

    Google Scholar 

  • Astumian, R. D., Chock, P. B., Westerhoff, H. V., and Tsong, T. Y., 1987b, in: “Enzyme Dynamics and Regulation,” P. B. Chock, C. Huang, L. Tsou, and J. H. Wang, eds., Sprinter, New York, in press.

    Google Scholar 

  • Astumian, R. D., Chock, P. B., Tsong, T. Y., and Westerhoff, H. V., 1987c, J. Chem. Phys., submitted.

    Google Scholar 

  • Chay, T. R. and Keizer, J., 1983, Biophys. J., 42: 181–190.

    Article  Google Scholar 

  • Chay, T. R. and Rinzel, J., 1985, Biophys. J., 47: 357–366.

    Article  Google Scholar 

  • Hess, B. and Boiteux, A., 1971, Ann. Rev. Biochem., 40: 237–258.

    Article  Google Scholar 

  • Hill, T. L., 1977, “Free Energy Transduction in Biology,” Academic Press, New York.

    Google Scholar 

  • Johnstone, R. M. and Laris, P. C., 1980, Biochim. Biophys. Acta, 599: 715–730.

    Article  Google Scholar 

  • Kinosita, K., Jr. and Tsong, T. Y., 1977a, Biochim. Biophys. Acta, 471: 227–242.

    Article  Google Scholar 

  • Kinosita, K., Jr. and Tsong, T. Y., 1977b, Nature (London), 268: 438–441.

    Article  ADS  Google Scholar 

  • Kinosita, K., Jr. and Tsong, T. Y., 1978, Nature (London), 272: 258–260.

    Article  ADS  Google Scholar 

  • Knox, B. E. and Tsong, T. Y., 1984, J. Biol. Chem., 259: 4747–4763.

    Google Scholar 

  • Lo, M. M. S., Tsong, T. Y., Strittmatter, S. M., Hester, L. D., and Snyder, S 1984, Nature, 310: 792–794.

    Article  ADS  Google Scholar 

  • Neumann, E., Schaefer-Rider, M., Wang, Y., and HofSchneider, P. H., 1982, EMBO J., 1: 841–845.

    Google Scholar 

  • Offner, F. F., 1980, J. Phys. Chem., 84: 2652–2662.

    Article  Google Scholar 

  • Offner, F. F., 1984, Biophys. J., 46: 447–461.

    Article  Google Scholar 

  • Schell, M., Kundo, K., and Ross, J., 1987, Proc. Natl. Acad. Sci. U.S.A. 84: 424–428.

    Article  ADS  Google Scholar 

  • Serpersu, E. H. and Tsong, T. Y., 1983, J. Membrane Biol., 74: 191–201.

    Article  Google Scholar 

  • Serpersu, E. H. and Tsong, T. Y., 1984, J. Biol. Chem., 259: 7155–7162.

    Google Scholar 

  • Sowers, A. E., 1986, J. Cell Biol., 102: 1358–1362.

    Article  Google Scholar 

  • Teissie, J. and Tsong, T. Y.,1980, J. Membrane Biol., 55: 133–140.

    Google Scholar 

  • Tsong, T. Y., 1983, Bioscience Reports, 3: 487–505.

    Article  Google Scholar 

  • Tsong, T. Y. and Astumian, R. D., 1986, Bioelectrochem. Bioenerg., 15: 457–476.

    Article  Google Scholar 

  • Tsong, T. Y. and Astumian, R. D., 1987, Prog. Biophys. Mol. Biol., in press.

    Google Scholar 

  • Tsong, T. Y. and Astumian, R. D., 1988, Ann. Rev. Physiol., in press.

    Google Scholar 

  • Westerhoff, H. V., Tsong, T. Y., Chock, P. B., Chen, Y.-d., and Astumian, R. D., 1986, Proc. Natl. Acad. Sci. U.S.A., 83: 4734–4738.

    Article  ADS  Google Scholar 

  • Westerhoff, H. V. and Astumian, R. D., 1987, In: “Towards a Cellular Enzymology,”, A. Klysov, S. Varfolomeev, and G. R. Welch, eds., Plenum Press, New York.

    Google Scholar 

  • Westerhoff, H. V., Kamp, F., Tsong, T. Y., and Astumian, R. D., 1987, in “Mechanistic Approaches to Interactions of Electromagnetic Fields With Living Systems,” M. Blank and E. Findl, eds., Plenum Press, New York, in press.

    Google Scholar 

  • Witt, H., Schlodder, E., and Graber, P., 1976, FEBS Lett., 69: 272–276.

    Article  Google Scholar 

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© 1988 Plenum Press, New York

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Astumian, R.D., Chock, P.B., Chauvin, F., Tsong, T.Y. (1988). Electroconformational Coupling and the Effects of Static and Dynamic Electric Fields on Membrane Transport. In: Markov, M., Blank, M. (eds) Electromagnetic Fields and Biomembranes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9507-6_7

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  • DOI: https://doi.org/10.1007/978-1-4615-9507-6_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4615-9509-0

  • Online ISBN: 978-1-4615-9507-6

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